Abstract
The purpose of the study: is to improve the diagnosis of multifactorial and monogenic chronic obstructive lung pathology (COLP).
Material and Methods: The study was conducted in 20 patients with COPD, 15 with mucoviscidosis (MV), and 10 with primary ciliary dyskinesia (PCD). The control indicators were patients with chronic bronchitis. A comprehensive assessment of the mucocociliary system (MCS) was performed in the following algorithm: the phase of relative remission - the assessment of the adhesive physical properties of sputum - if necessary, targeted electron microscopy of the bronchial epithelium. Treatment for all patients from the position of MCS was standard.
Results: The function of MCS in the phase of relative remission against the background of the positive dynamics of the adhesive properties of sputum remained significantly impaired in patients with COPD and PCD (p>0.05), while in patients with MV it was significantly restored (p<0.05). A targeted study of the ultrastructure of the bronchial epithelium revealed its obvious violations in patients with PCB and deviations characteristic of COPD, while in patients with CF they were absent.
Conclusion: The study of MDC in a specific algorithm extends the accuracy of differential diagnosis of COLP.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1911.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020
