Abstract
Aims: To assess the safety of the endobronchial valve use in patients.
Methods: We evaluated safety based on the development of complications during treatment. In total, 100 patients with MDR/XDR destructive TB combined with HIV infection participated in the study, of which 60 were randomized to EBV implantation (EBV group), and 40 patients to receive standard medical care (control group).
Results: on day 2 of the study in 24(40.0%) patients of the EBV-group a rare, dry cough appeared, in the control group in 3(7.5%) patients (p<0.001). In 5(8.3%) patients of the EBV group, an exacerbation of endobronchitis occurred, requiring special treatment, vs. 0 cases in the control group (p=0.05). All these manifestations disappeared within 3 weeks of treatment. When evaluating the bronchial tree after 1 year, patients of the EBV group showed an increase in granulation tissue in the blocking area in 100% of cases, of which 44(73.3%) had a significant amount (occupying more than 50% of the bronchus lumen). At 14 months, with bronchoscopy in patients of the EBV group, cicatricial changes in EBV site were also detected in 100% of cases, in 33(55.0%) circular bronchial stenoses were found, occupying more than 50% of the lumen of the bronchus, of which 16(26.7%) expressed, in which the lumen of the blocked bronchus was less than 1 mm. In the control group, there were no such changes.
Conclusions: The use of EBV in the complex treatment of patients with MDR/XDR TB combined with HIV infection leads to a decrease in the quality of life of the patient in the first two weeks of treatment and the development of cicatricial deformity of the bronchial tree in the long term.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1603.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020