Abstract
Background: According to the literature, protionamide (Pto) and para-aminosalicylic acid (PAS) used in the treatment of tuberculosis can cause thyroid dysfunction.
Aim: the determination of the effect of chemotherapy with the use of Pto and PAS, on the functional state of the thyroid gland.
Methods: 43 patients aged 18 to 60 years were examined, who did not have structural and functional changes in the thyroid gland in 2019. Group 1-25 patients with MDR /XDR treated with 4 and 5 chemotherapy regimens including Pto and PAS; Group 2 - 18 patients with MDR/XDR MBT treated without Pto and Pas. The structure of the thyroid gland was evaluated by ultrasound examination, radioisotope scanning with tс(technetium)-99 mm, and laboratory test.
Results: According to the ultrasound, no changes were detected after 6 months of anti-TB chemotherapy. A decrease in the accumulation of Tc-99 mm was detected in 1 patient (5.5) of 2 group according to the radioisotope scan by the 6th month of treatment. The levels of TSH, T4 and AT to TPO were normal in all patients. By the 6th month of treatment, 2 patients of the 1st group (8%) showed signs of subclinical hypothyroidism. (p> 0.05) An isolated decrease in T4 was observed in 5 patients (27.8%) of group 1, with a normal level of TSH.
Conclusions: All identified changes were recorded after 6 months of anti-TB chemotherapy. The changes were clinically insignificant and did not require treatment.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1598.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020