Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • ERS Guidelines
  • Authors/reviewers
    • Instructions for authors
    • Submit a manuscript
    • Open access
    • Peer reviewer login
  • Alerts
  • Subscriptions

Reference values for lung clearance index (LCI) derived from sulphur hexafluoride multiple breath washout testing

Frederik Trinkmann, Máté Maros, Katharina Roth, Arne Hermanns, Julia Schäfer, Joshua Gawlitza, Joachim Saur, Ibrahim Akin, Martin Borggrefe, Thomas Ganslandt, Felix Herth
European Respiratory Journal 2020 56: 147; DOI: 10.1183/13993003.congress-2020.147
Frederik Trinkmann
1Thoraxklinik Heidelberg, Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: frederik.trinkmann@med.uni-heidelberg.de
Máté Maros
2University Medical Center Mannheim, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katharina Roth
2University Medical Center Mannheim, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Arne Hermanns
2University Medical Center Mannheim, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Julia Schäfer
2University Medical Center Mannheim, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joshua Gawlitza
2University Medical Center Mannheim, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Joachim Saur
2University Medical Center Mannheim, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ibrahim Akin
2University Medical Center Mannheim, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Martin Borggrefe
2University Medical Center Mannheim, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas Ganslandt
2University Medical Center Mannheim, Mannheim, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Felix Herth
1Thoraxklinik Heidelberg, Heidelberg, Germany
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
Loading

Abstract

Background: Ventilation heterogeneity is frequent in obstructive lung disease and linked to small airway dysfunction. It can be potentially revealed using multiple breath washout (MBW) testing while being missed by commonly used tests. Lung clearance index (LCI) is the most commonly used MBW outcome parameter but normative data is scarce. We therefore set out to provide LCI reference values in pulmonary healthy adults.

Methods: We prospectively evaluated 104 pulmonary healthy non-smokers and smokers (mean age 51±20, range 20-88 years). LCI was derived from triplicate MBW measurements based on Sulphur hexafluoride (SF6). We used the 2.5% (LCI2.5) and 5% (LCI5) stopping points and defined upper limit of normal (ULN) as the 95th percentile.

Results: LCI2.5 increases from a mean 6.3 to 8.8 in subjects between 20 and 90 years. Upper limits of normal were calculated as of 7.4 to 9.9 (Figure). LCI5 correspondingly yielded lower mean values between 4.9 and 6.9 with ULN of 5.7 and 7.7, respectively. Age was the only meaningful parameter influencing LCI explaining 47% of its variance.

Conclusions: LCI showed an age-dependent increase from early adulthood to senectitude. No influence of height, weight and gender was seen. Reference values can now be provided over the whole age range and for two different stopping points.

Figure
  • Download figure
  • Open in new tab
  • Download powerpoint

  • Diagnosis
  • Measurement properties
  • Monitoring

Footnotes

Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 147.

This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2020
Previous
Back to top
Vol 56 Issue suppl 64 Table of Contents
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Reference values for lung clearance index (LCI) derived from sulphur hexafluoride multiple breath washout testing
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Reference values for lung clearance index (LCI) derived from sulphur hexafluoride multiple breath washout testing
Frederik Trinkmann, Máté Maros, Katharina Roth, Arne Hermanns, Julia Schäfer, Joshua Gawlitza, Joachim Saur, Ibrahim Akin, Martin Borggrefe, Thomas Ganslandt, Felix Herth
European Respiratory Journal Sep 2020, 56 (suppl 64) 147; DOI: 10.1183/13993003.congress-2020.147

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Reference values for lung clearance index (LCI) derived from sulphur hexafluoride multiple breath washout testing
Frederik Trinkmann, Máté Maros, Katharina Roth, Arne Hermanns, Julia Schäfer, Joshua Gawlitza, Joachim Saur, Ibrahim Akin, Martin Borggrefe, Thomas Ganslandt, Felix Herth
European Respiratory Journal Sep 2020, 56 (suppl 64) 147; DOI: 10.1183/13993003.congress-2020.147
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo

Jump To

  • Article
  • Figures & Data
  • Info & Metrics
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Acute exacerbation phenotypes of asthma and COPD: impact on clinical outcomes
  • Eosinophilic phenotype classification of patients with asthma and/or COPD in NOVELTY
  • Impact of anemia in patients admitted due to a chronic obstructive pulmonary disease (COPD) exacerbation
Show more Monitoring airway disease

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Publication ethics and malpractice
  • Submit a manuscript

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2023 by the European Respiratory Society