Abstract
Introduction: Hypersensitivity pneumonitis (HP) represents a chronic lung disease with limited clinically applicable biomarkers.
Aim: To investigate differences in parameters of HP severity based on subgroups of monocyte count and red cell distribution width (RDW).
Methods: Treatment-naïve patients with HP were prospectively enrolled in the study between 1/11/2018 and 14/02/2020. Monocyte count and RDW at baseline were recorded.
Results: Fifty one patients (n=51) were enrolled [29 males, median age: 69 years (95% CI: 64.0 to 71.9), median FVC%pred: 69.0 (95% CI: 55.0 to 73.9), median DLCO%pred: 37.0 (95%CI: 29.9 to 45.0), median monocyte count: 0.610 K/μL (95% CI: 0.558 to 0.698), median RDW: 14.0 (95% CI: 13.7 to 14.7)]. Patients with monocyte count>0.610 K/μL had significantly lower FVC%pred [median: 53.0, (95% CI: 48.2 to 72.0), vs. 73.0, (95% CI: 60.5 to 86.8), p= 0.03)] and DLCO%pred [median: 32.0, (95% CI: 25.1 to 42.4) vs. 43.0, (95% CI: 31.7 to 63.3), p=0.04] compared to patients with monocyte count<0.610 K/μL, respectively. Patients with RDW>14.0 had significantly lower FVC%pred [median: 54.0, (95% CI: 46.0 to 73.0) vs. 71.0, (95% CI: 58.5 to 85.3), p=0.02] compared to patients with RDW<14.0.
Conclusion: Increased monocyte count and RDW may represent negative prognosticators in patients with HP. Studies providing mechanistic insights are eagerly awaited.
Footnotes
Cite this article as: European Respiratory Journal 2020; 56: Suppl. 64, 1077.
This abstract was presented at the 2020 ERS International Congress, in session “Respiratory viruses in the "pre COVID-19" era”.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2020
