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Tailored exercise is safe and beneficial for acutely hospitalised older adults with COPD

Nicolás Martínez-Velilla, Pedro L. Valenzuela, Fabricio Zambom-Ferraresi, Mikel L. Sáez de Asteasu, Robinson Ramírez-Vélez, Antonio García-Hermoso, Alejandro Lucia, Mikel Izquierdo
European Respiratory Journal 2020 56: 2001048; DOI: 10.1183/13993003.01048-2020
Nicolás Martínez-Velilla
1Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain
2CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain
6These authors have contributed equally
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Pedro L. Valenzuela
3Dept of Systems Biology, University of Alcalá, Madrid, Spain
6These authors have contributed equally
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Fabricio Zambom-Ferraresi
1Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain
2CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain
6These authors have contributed equally
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Mikel L. Sáez de Asteasu
1Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain
2CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain
6These authors have contributed equally
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Robinson Ramírez-Vélez
1Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain
2CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain
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Antonio García-Hermoso
1Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain
2CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain
4Laboratorio de Ciencias de la Actividad Física, el Deporte y la Salud, Facultad de Ciencias Médicas, Universidad de Santiago de Chile, USACH, Santiago, Chile
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Alejandro Lucia
2CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain
5Faculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain
7These authors share senior authorship
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Mikel Izquierdo
1Navarrabiomed, Complejo Hospitalario de Navarra (CHN)-Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona, Spain
2CIBER of Frailty and Healthy Aging (CIBERFES), Instituto de Salud Carlos III, Madrid, Spain
7These authors share senior authorship
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  • ORCID record for Mikel Izquierdo
  • For correspondence: mikel.izquierdo@gmail.com
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Extract

COPD is predicted to affect approximately half of the older population in the next decade. The incidence of hospitalisations associated with this condition is also likely to rise, even surpassing those caused by major conditions (notably, ischaemic cardiomyopathy) [1]. In this context, the collateral effects of hospitalisation, even for a few days, must not be overlooked, especially in the oldest segment (>80 years). Nearly one third of older adults lose their ability to independently perform one or more activities of daily living from hospital admission to discharge even if successfully treated from the condition that caused hospitalisation, the so-called “hospital induced-disability”. This condition has major short- and long-term consequences, notably an increased risk of re-admission and mortality. Moreover, hospitalised patients with COPD present with a proinflammatory profile (i.e. elevated serum C-reactive protein (CRP)) and high range of variation in red blood cell volume (i.e. elevated red blood cell distribution width (RDW)), both features associated with poorer outcomes [2].

Abstract

Tailored exercise is safe and beneficial for acutely hospitalised older adults with chronic obstructive pulmonary disease https://bit.ly/2YfnqXt

Acknowledgement

The authors would like to thank the patients and their families for their confidence in the research team.

Footnotes

  • Author contributions: N. Martínez-Velilla, F. Zambom-Ferraresi, M.L. Sáez de Asteasu and M. Izquierdo designed the study. All authors undertook study related procedures. N. Martínez-Velilla, F. Zambom-Ferraresi, M.L. Sáez de Asteasu and M. Izquierdo collected the data. N. Martínez-Velilla, P.L. Valenzuela, F. Zambom-Ferraresi, M.L. Sáez de Asteasu, R. Ramírez-Vélez, A. García-Hermoso, A. Lucia and M. Izquierdo analysed and interpreted the data. N. Martínez-Velilla, P.L. Valenzuela, A. Lucia and M. Izquierdo wrote the paper, and all authors reviewed and revised the paper. All authors approved the final version.

  • Conflict of interest: N. Martínez-Velilla has nothing to disclose.

  • Conflict of interest: P.L. Valenzuela has nothing to disclose.

  • Conflict of interest: F. Zambom-Ferraresi has nothing to disclose.

  • Conflict of interest: M.L. Sáez de Asteasu has nothing to disclose.

  • Conflict of interest: R. Ramírez-Vélez has nothing to disclose.

  • Conflict of interest: A. García-Hermoso has nothing to disclose.

  • Conflict of interest: A. Lucia has nothing to disclose.

  • Conflict of interest: M. Izquierdo has nothing to disclose.

  • Support statement: This study was funded by a Gobierno de Navarra project Resolución grant 2186/2014 and acknowledged with the “Beca Ortiz de Landazuri” for the best research clinical project in 2014, as well as by a research grant PI17/01814 of the Ministerio de Economía, Industria y Competitividad (ISCIII, FEDER). R. Ramírez-Vélez is funded in part by a Postdoctoral fellowship grant (ID 420/2019) of the Universidad Pública de Navarra, Spain.

  • Received April 7, 2020.
  • Accepted June 12, 2020.
  • Copyright ©ERS 2020
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Tailored exercise is safe and beneficial for acutely hospitalised older adults with COPD
Nicolás Martínez-Velilla, Pedro L. Valenzuela, Fabricio Zambom-Ferraresi, Mikel L. Sáez de Asteasu, Robinson Ramírez-Vélez, Antonio García-Hermoso, Alejandro Lucia, Mikel Izquierdo
European Respiratory Journal Dec 2020, 56 (6) 2001048; DOI: 10.1183/13993003.01048-2020

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Tailored exercise is safe and beneficial for acutely hospitalised older adults with COPD
Nicolás Martínez-Velilla, Pedro L. Valenzuela, Fabricio Zambom-Ferraresi, Mikel L. Sáez de Asteasu, Robinson Ramírez-Vélez, Antonio García-Hermoso, Alejandro Lucia, Mikel Izquierdo
European Respiratory Journal Dec 2020, 56 (6) 2001048; DOI: 10.1183/13993003.01048-2020
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