Lung function | | | | | | | | |
ΔFEV1 mL | −33.2±166.9 (−91.5 to 25.0) | 0.25 | | | | | −96.5±197.7 (−169.0 to −23.9) | 0.01 |
ΔFEV1 % | −0.7±5.7 (−2.7 to 1.3) | 0.45 | | | | | −2.4±6.5 (−4.8 to 0.0) | 0.05 |
ΔFVC mL | −125.9±330.4 (−241.2 to −10.6) | 0.03 | | | | | −191.3±483.7 (−368.7 to −13.9) | 0.04 |
ΔFVC % | −3.1±9.5 (−6.4 to 0.2) | 0.06 | | | | | −2.8±13.0 (−7.6 to 2.0) | 0.24 |
ΔFEV1/FVC % | 0.3±10.6 (−3.5 to 4.0) | 0.89 | | | | | −0.9±3.6 (−2.2 to 0.4) | 0.18 |
ΔFIV1 mL | −175.8±389.5 (−340.3 to −11.4) | 0.04 | | | | | −66.2±371.1 (−235.1 to 102.7) | 0.42 |
ΔVC L | 1.2±6.6 (−1.4 to 3.9) | 0.35 | | | | | −0.1±0.4 (−0.3 to 0.1) | 0.49 |
ΔRaw kPa·s·L−1 | 0.1±0.3 (−0.1 to 0.2) | 0.28 | | | | | 0.0±0.2 (−0.1 to 0.2) | 0.33 |
Exercise capacity | | | | | | | | |
Δ6MWD m | 1.1±55.4 (−18.6 to 20.7) | 0.91 | 20.3±72.0 (−6.6 to 47.2) | 0.13 | 24.3±65.0 (−0.4 to 49.0) | 0.05 | 8.5±76.2 (−19.4 to 36.5) | 0.54 |
Symptoms | | | | | | | | |
ΔmMRC | 0 (IQR −1 to 0) | 0.29¶ | 0 (IQR −1 to 0) | 0.10¶ | 0 (IQR −1 to 0) | 0.16¶ | 0 (IQR −1 to 0) | 0.30¶ |
ΔCAT# | −3.8±7.1 (−6.4 to −1.3) | <0.01 | −3.4±6.8 (−5.9 to −0.9) | 0.01 | −0.9±7.7 (−3.8 to 2.0) | 0.53 | −2.0±7.2 (−4.7 to 0.6) | 0.12 |
ΔSGRQ total score | −6.4±14.4 (−11.4 to −1.3) | 0.01 | −9.5±15.7 (−15.4 to −3.6) | <0.01 | −6.9±16.2 (−13.0 to −0.9) | 0.03 | −4.6±15.1 (−10.2 to 0.9) | 0.10 |
ΔSGRQ symptoms | −6.3±22.1 (−14.0 to 1.4) | 0.10 | −8.8±19.6 (−16.1 to −1.4) | 0.02 | −4.9±21.9 (−13.1 to 3.3) | 0.23 | −4.3±21.5 (−12.2 to 3.5) | 0.27 |
ΔSGRQ activity | −2.5±15.0 (−7.7 to 2.7) | 0.34 | −4.4±17.5 (−11.0 to 2.1) | 0.17 | −2.6±17.9 (−9.3 to 4.1) | 0.43 | −2.5±14.8 (−7.9 to 3.0) | 0.36 |
ΔSGRQ impacts | −8.7±16.7 (−14.5 to −2.9) | <0.01 | −12.9±17.9 (−19.6 to −6.2) | <0.01 | −10.2±18.4 (−17.1 to −3.4) | <0.01 | −6.1±20.0 (−13.4 to 1.3) | 0.10 |
ΔLCQ | 21.6±32.2 (7.3 to 35.9) | <0.01 | 21.6±29.2 (8.3 to 34.9) | <0.01 | 13.4±24.1 (2.1 to 24.6) | 0.02 | 9.1±29.0 (−4.1 to 22.3) | 0.17 |
ΔVAS rest# | −3.6±31.5 (−14.8 to 7.5) | 0.51 | −2.7±25.5 (−12.2 to 6.9) | 0.57 | −1.1±31.1 (−12.8 to 10.5) | 0.85 | −0.4±25.4 (−9.7 to 8.9) | 0.93 |
ΔVAS activity# | −7.2±22.2 (−15.0 to 0.7) | 0.07 | −10.3±22.4 (−18.7 to −1.9) | 0.02 | −7.1±25.2 (−17.3 to 1.9) | 0.13 | −6.7±21.4 (−14.6 to 1.2) | 0.09 |
Mortality score | | | | | | | | |
ΔBODE index | −0.1±1.1 (−0.5 to 0.3) | 0.54 | | | | | 0.1±1.4 (−0.4 to 0.6) | 0.61 |
Inflammatory marker | | | | | | | | |
ΔFibrinogen mg·dL−1 | 45.2±84.5 (15.2 to 75.1) | <0.01 | | | | | 29.3±65.2 (4.5 to 54.1) | 0.02 |