“Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians.” Sanja Stanojevic, Brian L. Graham, Brendan G. Cooper, Bruce R. Thompson, Kim W. Carter, Richard W. Francis and Graham L. Hall on behalf of the Global Lung Function Initiative TLCO working group. Eur Respir J 2017; 50: 1700010.

doi:10.1183/13993003.50010-2017

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FIGURE 1
Summary of differences in the predicted values using the original Global Lung Function Initiative (GLI) equations (red) and the updated equations (blue).

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TABLE 2

The corrected equations for predicted values for the median (M), the variability around the median (S) and the skewness (L) for each of the T_LCO test outcomes (transfer factor of the lung for carbon monoxide (T_LCO), transfer coefficient of the lung for carbon monoxide (K_CO) and alveolar volume (V_A))

	M	S	L
Male
T_LCO mmol·min^-1·kPa^-1	exp(-8.129189 + 2.018368·ln(height) - 0.012425·ln(age) + Mspline)	exp(-1.98996 + 0.03536·ln (age) + Sspline)	0.39482
D_LCO mL·min^-1·mmHg^-1	exp(-7.034920 + 2.018368·ln(height) - 0.012425·ln(age) + Mspline)	exp(-1.98996 + 0.03536·ln (age) + Sspline)	0.39482

K_CO (SI) mmol·min^-1·kPa^-1·L^-1	exp(2.994137 - 0.415334·ln(height) - 0.113166·ln(age) + Mspline)	exp(-1.98186 + 0.01460·ln(age) + Sspline)	0.67330
K_CO (trad) mL·min^-1·mmHg^-1·L^-1	exp(4.088408 - 0.415334·ln(height) - 0.113166·ln(age) + Mspline)	exp(-1.98186 + 0.01460·ln(age) + Sspline)	0.67330

V_A L	exp(-11.086573 + 2.430021·ln(height) + 0.097047·ln(age) + Mspline)	exp(-2.20953 + 0.01937·ln(age) + Sspline)	0.62559

Female
T_LCO mmol·min^-1·kPa^-1	exp(-6.253720 + 1.618697·ln(height) - 0.015390·ln(age) + Mspline)	exp(-1.82905 - 0.01815·ln(age) + Sspline)	0.24160
D_LCO mL·min^-1·mmHg^-1	exp(-5.159451 + 1.618697·ln(height) - 0.015390·ln(age) + Mspline)	exp(-1.82905 - 0.01815·ln(age) + Sspline)	0.24160

K_CO (SI) mmol·min^-1·kPa^-1·L^-1	exp(4.037222 - 0.645656·ln(height) - 0.097395·ln(age) + Mspline)	exp(-1.63787 - 0.07757·ln(age) + Sspline)	0.48963
K_CO (trad) mL·min^-1·mmHg^-1·L^-1	exp(5.131492 - 0.645656·ln(height) - 0.097395·ln(age) + Mspline)	exp(-1.63787 - 0.07757·ln(age) + Sspline)	0.48963

V_A L	exp(-9.873970 + 2.182316·ln(height) + 0.082868·ln(age) + Mspline)	exp(-2.08839 - 0.01334·ln(age) + Sspline)	0.51919

Mspline, Sspline correspond to the age-varying coefficients from the look-up tables provided in the supplementary material. Height and age are expressed as cm and years, respectively. Predicted value: M; lower limit of normal (5th percentile): exp(ln(M) + ln(1 - 1.645·L·S)/L); upper limit of normal (5th percentile): exp(ln(M) + ln(1 + 1.645·L·S)/L); z-score: ((measured/M)^L - 1)/(L·S); % predicted: (measured/M)·100; exp: natural exponential; ln: natural logarithm. This table has been amended in the article originally published in the September 2017 issue of the European Respiratory Journal.