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“Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians.” Sanja Stanojevic, Brian L. Graham, Brendan G. Cooper, Bruce R. Thompson, Kim W. Carter, Richard W. Francis and Graham L. Hall on behalf of the Global Lung Function Initiative TLCO working group. Eur Respir J 2017; 50: 1700010.

European Respiratory Journal 2020 56: 1750010; DOI: 10.1183/13993003.50010-2017
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    FIGURE 1

    Summary of differences in the predicted values using the original Global Lung Function Initiative (GLI) equations (red) and the updated equations (blue).

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  • TABLE 2

    The corrected equations for predicted values for the median (M), the variability around the median (S) and the skewness (L) for each of the TLCO test outcomes (transfer factor of the lung for carbon monoxide (TLCO), transfer coefficient of the lung for carbon monoxide (KCO) and alveolar volume (VA))

    MSL
    Male
    TLCO mmol·min-1·kPa-1exp(-8.129189 + 2.018368·ln(height) - 0.012425·ln(age) + Mspline)exp(-1.98996 + 0.03536·ln (age) + Sspline)0.39482
    DLCO mL·min-1·mmHg-1exp(-7.034920 + 2.018368·ln(height) - 0.012425·ln(age) + Mspline)
     
    KCO (SI) mmol·min-1·kPa-1·L-1exp(2.994137 - 0.415334·ln(height) - 0.113166·ln(age) + Mspline)exp(-1.98186 + 0.01460·ln(age) + Sspline)0.67330
    KCO (trad) mL·min-1·mmHg-1·L-1exp(4.088408 - 0.415334·ln(height) - 0.113166·ln(age) + Mspline)
     
    VA Lexp(-11.086573 + 2.430021·ln(height) + 0.097047·ln(age) + Mspline)exp(-2.20953 + 0.01937·ln(age) + Sspline)0.62559
     
    Female
    TLCO mmol·min-1·kPa-1exp(-6.253720 + 1.618697·ln(height) - 0.015390·ln(age) + Mspline)exp(-1.82905 - 0.01815·ln(age) + Sspline)0.24160
    DLCO mL·min-1·mmHg-1exp(-5.159451 + 1.618697·ln(height) - 0.015390·ln(age) + Mspline)
     
    KCO (SI) mmol·min-1·kPa-1·L-1exp(4.037222 - 0.645656·ln(height) - 0.097395·ln(age) + Mspline)exp(-1.63787 - 0.07757·ln(age) + Sspline)0.48963
    KCO (trad) mL·min-1·mmHg-1·L-1exp(5.131492 - 0.645656·ln(height) - 0.097395·ln(age) + Mspline)
     
    VA Lexp(-9.873970 + 2.182316·ln(height) + 0.082868·ln(age) + Mspline)exp(-2.08839 - 0.01334·ln(age) + Sspline)0.51919

    Mspline, Sspline correspond to the age-varying coefficients from the look-up tables provided in the supplementary material. Height and age are expressed as cm and years, respectively. Predicted value: M; lower limit of normal (5th percentile): exp(ln(M) + ln(1 - 1.645·L·S)/L); upper limit of normal (5th percentile): exp(ln(M) + ln(1 + 1.645·L·S)/L); z-score: ((measured/M)L - 1)/(L·S); % predicted: (measured/M)·100; exp: natural exponential; ln: natural logarithm. This table has been amended in the article originally published in the September 2017 issue of the European Respiratory Journal.

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    Vol 56 Issue 4 Table of Contents
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    “Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians.” Sanja Stanojevic, Brian L. Graham, Brendan G. Cooper, Bruce R. Thompson, Kim W. Carter, Richard W. Francis and Graham L. Hall on behalf of the Global Lung Function Initiative TLCO working group. Eur Respir J 2017; 50: 1700010.
    European Respiratory Journal Oct 2020, 56 (4) 1750010; DOI: 10.1183/13993003.50010-2017

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    “Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians.” Sanja Stanojevic, Brian L. Graham, Brendan G. Cooper, Bruce R. Thompson, Kim W. Carter, Richard W. Francis and Graham L. Hall on behalf of the Global Lung Function Initiative TLCO working group. Eur Respir J 2017; 50: 1700010.
    European Respiratory Journal Oct 2020, 56 (4) 1750010; DOI: 10.1183/13993003.50010-2017
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