European Respiratory Journal: 56 (4)

01 October 2020; volume 56, issue 4

Editorials

Open Access
Confronting the controversy: interleukin-6 and the COVID-19 cytokine storm syndrome
Luke Y.C. Chen, Ryan L. Hoiland, Sophie Stukas, Cheryl L. Wellington, Mypinder S. Sekhon

European Respiratory Journal 56 (4) 2003006; DOI: 10.1183/13993003.03006-2020 Published 1 October 2020
Open Access
Confronting and mitigating the risk of COVID-19 associated pulmonary aspergillosis
Darius Armstrong-James, Jonathan Youngs, Tihana Bicanic, Alireza Abdolrasouli, David W. Denning, Elizabeth Johnson, Varun Mehra, Tony Pagliuca, Brijesh Patel, Johanna Rhodes, Silke Schelenz, Anand Shah, Frank L. van de Veerdonk, Paul E. Verweij, P. Lewis White, Matthew C. Fisher

European Respiratory Journal 56 (4) 2002554; DOI: 10.1183/13993003.02554-2020 Published 1 October 2020
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Modernising case finding for α₁-antitrypsin deficiency by DNA sequencing of COPD patients
Mark Quinn, Alice M. Turner

European Respiratory Journal 56 (4) 2002628; DOI: 10.1183/13993003.02628-2020 Published 15 October 2020
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Pseudomonas and risk factor mitigation for chronic lung allograft dysfunction
Allan R. Glanville

European Respiratory Journal 56 (4) 2001968; DOI: 10.1183/13993003.01968-2020 Published 1 October 2020
Open Access
How can we better predict pulmonary blood clots in patients hospitalised for COVID-19?
Laurent Bertoletti, Menno V. Huisman

European Respiratory Journal 56 (4) 2003092; DOI: 10.1183/13993003.03092-2020 Published 22 October 2020

Task Force Report

Open Access
Epidemic and pandemic viral infections: impact on tuberculosis and the lung
Catherine Wei Min Ong, Giovanni Battista Migliori, Mario Raviglione, Gavin MacGregor-Skinner, Giovanni Sotgiu, Jan-Willem Alffenaar, Simon Tiberi, Cornelia Adlhoch, Tonino Alonzi, Sophia Archuleta, Sergio Brusin, Emmanuelle Cambau, Maria Rosaria Capobianchi, Concetta Castilletti, Rosella Centis, Daniela M. Cirillo, Lia D'Ambrosio, Giovanni Delogu, Susanna M.R. Esposito, Jose Figueroa, Jon S. Friedland, Benjamin Choon Heng Ho, Giuseppe Ippolito, Mateja Jankovic, Hannah Yejin Kim, Senia Rosales Klintz, Csaba Ködmön, Eleonora Lalle, Yee Sin Leo, Chi-Chiu Leung, Anne-Grete Märtson, Mario Giovanni Melazzini, Saeid Najafi Fard, Pasi Penttinen, Linda Petrone, Elisa Petruccioli, Emanuele Pontali, Laura Saderi, Miguel Santin, Antonio Spanevello, Reinout van Crevel, Marieke J. van der Werf, Dina Visca, Miguel Viveiros, Jean-Pierre Zellweger, Alimuddin Zumla, Delia Goletti

European Respiratory Journal 56 (4) 2001727; DOI: 10.1183/13993003.01727-2020 Published 1 October 2020

Original Articles

Bronchiectasis
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  Changes in respiratory symptoms during 48-week treatment with ARD-3150 (inhaled liposomal ciprofloxacin) in bronchiectasis: results from the ORBIT-3 and -4 studies
  James D. Chalmers, David Cipolla, Bruce Thompson, Angela M. Davis, Anne O'Donnell, Gregory Tino, Igor Gonda, Charles Haworth, Juergen Froehlich
  
  European Respiratory Journal 56 (4) 2000110; DOI: 10.1183/13993003.00110-2020 Published 22 October 2020
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  Sputum neutrophil elastase associates with microbiota and Pseudomonas aeruginosa in bronchiectasis
  Martina Oriano, Andrea Gramegna, Leonardo Terranova, Giovanni Sotgiu, Imran Sulaiman, Luca Ruggiero, Laura Saderi, Benjamin Wu, James D. Chalmers, Leopoldo N. Segal, Paola Marchisio, Francesco Blasi, Stefano Aliberti
  
  European Respiratory Journal 56 (4) 2000769; DOI: 10.1183/13993003.00769-2020 Published 22 October 2020
COPD
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  Granularity of SERPINA1 alleles by DNA sequencing in CanCOLD
  Nisha Gupta, Nathalie Gaudreault, Sébastien Thériault, Pei Zhi Li, Cyndi Henry, Miranda Kirby, François Maltais, Wan Tan, Jean Bourbeau, Yohan Bossé
  
  European Respiratory Journal 56 (4) 2000958; DOI: 10.1183/13993003.00958-2020 Published 15 October 2020
Asthma
- Open Access
  Real-world mepolizumab in the prospective severe asthma REALITI-A study: initial analysis
  Tim Harrison, Giorgio Walter Canonica, Geoffrey Chupp, Jason Lee, Florence Schleich, Tobias Welte, Antonio Valero, Kim Gemzoe, Aoife Maxwell, Sandra Joksaite, Shibing Yang, Peter Howarth, Melissa K. Van Dyke
  
  European Respiratory Journal 56 (4) 2000151; DOI: 10.1183/13993003.00151-2020 Published 15 October 2020
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  Suboptimal treatment response to anti-IL-5 monoclonal antibodies in severe eosinophilic asthmatics with airway autoimmune phenomena
  Manali Mukherjee, David Felipe Forero, Stephanie Tran, Marie-Eve Boulay, Mylène Bertrand, Anurag Bhalla, Jayant Cherukat, Hajar Al-Hayyan, Anmar Ayoub, Spencer D. Revill, Tanvi Javkar, Katherine Radford, Melanie Kjarsgaard, Chynna Huang, Anna Dvorkin-Gheva, Kjetil Ask, Ronald Olivenstein, Nandini Dendukuri, Catherine Lemiere, Louis-Philippe Boulet, James G. Martin, Parameswaran Nair
  
  European Respiratory Journal 56 (4) 2000117; DOI: 10.1183/13993003.00117-2020 Published 8 October 2020
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  Self-titration of inhaled corticosteroid and β₂-agonist in response to symptoms in mild asthma: a pre-specified analysis from the PRACTICAL randomised controlled trial
  Christina Baggott, Jo Hardy, Jenny Sparks, Mark Holliday, Daniela Hall, Alexandra Vohlidkova, Robert J. Hancox, Mark Weatherall, James Fingleton, Richard Beasley on behalf of the PRACTICAL Study Team
  
  European Respiratory Journal 56 (4) 2000170; DOI: 10.1183/13993003.00170-2020 Published 8 October 2020
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  Risks for cold frequency vary by sex: role of asthma, age, TLR7 and leukocyte subsets
  Liisa M. Murray, Stephanie T. Yerkovich, Manuel A. Ferreira, John W. Upham
  
  European Respiratory Journal 56 (4) 1902453; DOI: 10.1183/13993003.02453-2019 Published 8 October 2020
Lung transplantation
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  Successful Pseudomonas aeruginosa eradication improves outcomes after lung transplantation: a retrospective cohort analysis
  Benedicte De Muynck, Anke Van Herck, Annelore Sacreas, Tobias Heigl, Janne Kaes, Arno Vanstapel, Stijn E. Verleden, Arne P. Neyrinck, Laurens J. Ceulemans, Dirk E. Van Raemdonck, Katrien Lagrou, Bart M. Vanaudenaerde, Geert M. Verleden, Robin Vos the Leuven Lung Transplant Group
  
  European Respiratory Journal 56 (4) 2001720; DOI: 10.1183/13993003.01720-2020 Published 1 October 2020
Pulmonary infections
- Open Access
  Elevated D-dimers and lack of anticoagulation predict PE in severe COVID-19 patients
  Basile Mouhat, Matthieu Besutti, Kevin Bouiller, Franck Grillet, Charles Monnin, Fiona Ecarnot, Julien Behr, Gilles Capellier, Thibaud Soumagne, Sébastien Pili-Floury, Guillaume Besch, Guillaume Mourey, Quentin Lepiller, Catherine Chirouze, François Schiele, Romain Chopard, Nicolas Meneveau
  
  European Respiratory Journal 56 (4) 2001811; DOI: 10.1183/13993003.01811-2020 Published 22 October 2020
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  Identification of potentially undiagnosed patients with nontuberculous mycobacterial lung disease using machine learning applied to primary care data in the UK
  Orla M. Doyle, Roald van der Laan, Marko Obradovic, Peter McMahon, Flora Daniels, Ashley Pitcher, Michael R. Loebinger
  
  European Respiratory Journal 56 (4) 2000045; DOI: 10.1183/13993003.00045-2020 Published 1 October 2020
Pulmonary hypertension
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  CAMPHOR score: patient-reported outcomes are improved by pulmonary endarterectomy in chronic thromboembolic pulmonary hypertension
  Michael Newnham, Katherine Bunclark, Nisha Abraham, Samantha Ali, Liliana Amaral-Almeida, John E. Cannon, Natalie Doughty, Choo Ng, Anie Ponnaberanam, Karen Sheares, Nicola Speed, Dolores Taboada, Mark Toshner, Steven Tsui, David P. Jenkins, Joanna Pepke-Zaba
  
  European Respiratory Journal 56 (4) 1902096; DOI: 10.1183/13993003.02096-2019 Published 1 October 2020
Respiratory muscles
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  ICU outcomes can be predicted by noninvasive muscle evaluation: a meta-analysis
  Clément Medrinal, Yann Combret, Roger Hilfiker, Guillaume Prieur, Nadine Aroichane, Francis-Edouard Gravier, Tristan Bonnevie, Olivier Contal, Bouchra Lamia
  
  European Respiratory Journal 56 (4) 1902482; DOI: 10.1183/13993003.02482-2019 Published 1 October 2020
Dyspnoea
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  A frame of reference for assessing the intensity of exertional dyspnoea during incremental cycle ergometry
  J. Alberto Neder, Danilo C. Berton, Luiz E. Nery, Wan C. Tan, Jean Bourbeau, Denis E. O'Donnell the Canadian Cohort of Obstructive Lung Disease (CanCOLD) Collaborative Research Group and the Canadian Respiratory Research Network (CRRN)
  
  European Respiratory Journal 56 (4) 2000191; DOI: 10.1183/13993003.00191-2020 Published 1 October 2020
Paediatrics
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  Predicting extubation outcomes using the Heart Rate Characteristics index in preterm infants: a cohort study
  Mallinath Chakraborty, William John Watkins, Katherine Tansey, William E. King, Sujoy Banerjee
  
  European Respiratory Journal 56 (4) 1901755; DOI: 10.1183/13993003.01755-2019 Published 1 October 2020

Back to Basics

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Perspectives on neuroinflammation contributing to chronic cough
Alexandria K. Driessen, Anna-Claire Devlin, Fionnuala T. Lundy, S. Lorraine Martin, Gerard P. Sergeant, Stuart B. Mazzone, Lorcan P. McGarvey

European Respiratory Journal 56 (4) 2000758; DOI: 10.1183/13993003.00758-2020 Published 22 October 2020

Agora

Research letters
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  Pulmonary interstitial glycogenosis cells express mesenchymal stem cell markers
  Csaba Galambos, Eric Wartchow, Jason P. Weinman, Steven H. Abman
  
  European Respiratory Journal 56 (4) 2000853; DOI: 10.1183/13993003.00853-2020 Published 22 October 2020
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  Dose optimisation of first-line tuberculosis drugs using therapeutic drug monitoring in saliva: feasible for rifampicin, not for isoniazid
  Simone H.J. van den Elsen, Onno W. Akkerman, Mireille Wessels, Erwin M. Jongedijk, Samiksha Ghimire, Tjip S. van der Werf, Mathieu S. Bolhuis, Daan J. Touw, Jan-Willem C. Alffenaar
  
  European Respiratory Journal 56 (4) 2000803; DOI: 10.1183/13993003.00803-2020 Published 22 October 2020
- Open Access
  Does chemotherapy reactivate SARS-CoV-2 in cancer patients recovered from prior COVID-19 infection?
  Jianping Bi, Hong Ma, Dongsheng Zhang, Jing Huang, Dongqin Yang, Yajie Wang, Vivek Verma, Tao Zhang, Desheng Hu, Qi Mei, Guang Han, Jian Li
  
  European Respiratory Journal 56 (4) 2002672; DOI: 10.1183/13993003.02672-2020 Published 22 October 2020
- Open Access
  Helmet CPAP treatment in patients with COVID-19 pneumonia: a multicentre cohort study
  Stefano Aliberti, Dejan Radovanovic, Filippo Billi, Giovanni Sotgiu, Matteo Costanzo, Tommaso Pilocane, Laura Saderi, Andrea Gramegna, Angelo Rovellini, Luca Perotto, Valter Monzani, Pierachille Santus, Francesco Blasi
  
  European Respiratory Journal 56 (4) 2001935; DOI: 10.1183/13993003.01935-2020 Published 15 October 2020
- Open Access
  Low physical functioning and impaired performance of activities of daily life in COVID-19 patients who survived hospitalisation
  Stefano Belli, Bruno Balbi, Ilaria Prince, Davide Cattaneo, Francesca Masocco, Sergio Zaccaria, Luca Bertalli, Francesco Cattini, Arianna Lomazzo, Francesca Dal Negro, Marica Giardini, Frits M.E. Franssen, Daisy J.A. Janssen, Martijn A. Spruit
  
  European Respiratory Journal 56 (4) 2002096; DOI: 10.1183/13993003.02096-2020 Published 15 October 2020
- Open Access
  Utility and safety of bronchoscopy during the SARS-CoV-2 outbreak in Italy: a retrospective, multicentre study
  Michele Mondoni, Giuseppe Francesco Sferrazza Papa, Rocco Rinaldo, Paola Faverio, Almerico Marruchella, Francesca D'Arcangelo, Alberto Pesci, Simone Pasini, Sonia Henchi, Giuseppe Cipolla, Francesco Tarantini, Lisa Giuliani, Fabiano Di Marco, Laura Saracino, Stefano Tomaselli, Angelo Corsico, Stefano Gasparini, Martina Bonifazi, Lina Zuccatosta, Laura Saderi, Giulia Pellegrino, Matteo Davì, Paolo Carlucci, Stefano Centanni, Giovanni Sotgiu
  
  European Respiratory Journal 56 (4) 2002767; DOI: 10.1183/13993003.02767-2020 Published 15 October 2020
- Open Access
  Limited role for bronchoalveolar lavage to exclude COVID-19 after negative upper respiratory tract swabs: a multicentre study
  Pietro Geri, Francesco Salton, Lina Zuccatosta, Mario Tamburrini, Marco Biolo, Annalisa Busca, Mario Santagiuliana, Umberto Zuccon, Paola Confalonieri, Barbara Ruaro, Pierlanfranco D'Agaro, Stefano Gasparini, Marco Confalonieri
  
  European Respiratory Journal 56 (4) 2001733; DOI: 10.1183/13993003.01733-2020 Published 8 October 2020
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  Difficult to treat microorganisms in patients aged over 80 years with community-acquired pneumonia: the prevalence of PES pathogens
  Catia Cilloniz, Cristina Dominedo, Héctor José Peroni, Pierluigi Di Giannatale, Carolina Garcia-Vidal, Albert Gabarrus, Adamanthia Liapikou, Adrian Ceccato, Antoni Torres
  
  European Respiratory Journal 56 (4) 2000773; DOI: 10.1183/13993003.00773-2020 Published 8 October 2020
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  Ambulatory treatment of low-risk pulmonary embolism in fragile patients: a subgroup analysis of the multinational Home Treatment of Pulmonary Embolism (HoT-PE) Trial
  Lukas Hobohm, Toni Anušić, Stavros V. Konstantinides, Stefano Barco for the HoT-PE Investigators
  
  European Respiratory Journal 56 (4) 2000663; DOI: 10.1183/13993003.00663-2020 Published 8 October 2020
- Open Access
  An observational study of the lung clearance index throughout childhood in cystic fibrosis: early years matter
  Gwyneth Davies, Sanja Stanojevic, Emma Raywood, Julie A. Duncan, Janet Stocks, Sooky Lum, Andrew Bush, Laura Viviani, Angie Wade, Alistair Calder, Catherine M. Owens, Christophe Goubau, Siobhán B. Carr, Cara J. Bossley, Caroline Pao, Paul Aurora on behalf of the London Cystic Fibrosis Collaboration
  
  European Respiratory Journal 56 (4) 2000006; DOI: 10.1183/13993003.00006-2020 Published 1 October 2020
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  Airway abundance of Haemophilus influenzae predicts response to azithromycin in adults with persistent uncontrolled asthma
  Steven L. Taylor, Kerry L. Ivey, Peter G. Gibson, Jodie L. Simpson, Geraint B. Rogers
  
  European Respiratory Journal 56 (4) 2000194; DOI: 10.1183/13993003.00194-2020 Published 1 October 2020
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  The Factor V Leiden variant and risk of chronic thromboembolic pulmonary hypertension
  Mark W. Dodson, Kelli Sumner, Jadyn Carlsen, Meghan M. Cirulis, Emily L. Wilson, Abhishek Gadre, Timothy M. Fernandes, Lynette M. Brown, D. Hunter Best, C. Gregory Elliott
  
  European Respiratory Journal 56 (4) 2000774; DOI: 10.1183/13993003.00774-2020 Published 1 October 2020
Correspondence
- Open Access
  The impact of COVID-19 and the restoration of tuberculosis services in the Western Pacific Region
  Chen-Yuan Chiang, Tauhid Islam, Caihong Xu, Thilaka Chinnayah, Anna Marie Celina Garfin, Kalpeshsinh Rahevar, Mario Raviglione
  
  European Respiratory Journal 56 (4) 2003054; DOI: 10.1183/13993003.03054-2020 Published 22 October 2020
- Open Access
  Endothelial to mesenchymal transition: a precursor to post-COVID-19 interstitial pulmonary fibrosis and vascular obliteration?
  Mathew Suji Eapen, Wenying Lu, Archana Vijay Gaikwad, Prem Bhattarai, Collin Chia, Ashutosh Hardikar, Greg Haug, Sukhwinder Singh Sohal
  
  European Respiratory Journal 56 (4) 2003167; DOI: 10.1183/13993003.03167-2020 Published 15 October 2020
- Open Access
  Correlation and causality: a COVID-19 conundrum
  Alyn H. Morice
  
  European Respiratory Journal 56 (4) 2003174; DOI: 10.1183/13993003.03174-2020 Published 15 October 2020
- Open Access
  A cuckoo COVID coincidence?
  James D. Chalmers, Mike Lonergan
  
  European Respiratory Journal 56 (4) 2003236; DOI: 10.1183/13993003.03236-2020 Published 15 October 2020
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  Technical standards for respiratory oscillometry: test loads for calibration and verification
  Cindy Thamrin, Raffaele L. Dellacà, Graham L. Hall, David W. Kaczka, Geoffrey N. Maksym, Ellie Oostveen, Shannon J. Simpson, Gregory G. King on behalf of the authors of the ERS technical standards for respiratory oscillometry
  
  European Respiratory Journal 56 (4) 2003369; DOI: 10.1183/13993003.03369-2020 Published 8 October 2020
- Open Access
  High-flow nasal cannula for COVID-19 patients: risk of bio-aerosol dispersion
  Judith Elshof, Rutger H.J. Hebbink, Marieke L. Duiverman, Rob Hagmeijer
  
  European Respiratory Journal 56 (4) 2003004; DOI: 10.1183/13993003.03004-2020 Published 8 October 2020
- Open Access
  High-flow nasal cannula for COVID-19 patients: risk of bio-aerosol dispersion
  Jie Li, James B. Fink, Stephan Ehrmann
  
  European Respiratory Journal 56 (4) 2003136; DOI: 10.1183/13993003.03136-2020 Published 8 October 2020
- Open Access
  Impact of the SARS-CoV-2 epidemic on tuberculosis treatment outcome in Northern Italy
  Paola Magro, Beatrice Formenti, Valentina Marchese, Maurizio Gulletta, Lina Rachele Tomasoni, Silvio Caligaris, Francesco Castelli, Alberto Matteelli
  
  European Respiratory Journal 56 (4) 2002665; DOI: 10.1183/13993003.02665-2020 Published 1 October 2020
- Open Access
  Healthcare workers with COVID-19 in Mexico
  Silvio A. Ñamendys-Silva
  
  European Respiratory Journal 56 (4) 2002885; DOI: 10.1183/13993003.02885-2020 Published 1 October 2020
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  The determination of ventilatory inefficiency at rest in COPD: the expected parameter
  Iván Caviedes, Rodrigo Soto, Felix Herth
  
  European Respiratory Journal 56 (4) 2002947; DOI: 10.1183/13993003.02947-2020 Published 1 October 2020

Author Statement

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“Pioglitazone attenuates endotoxin-induced acute lung injury by reducing neutrophil recruitment.” Jochen Grommes, Mathias Mörgelin and Oliver Soehnlein. Eur Respir J 2012; 40: 416–423
European Respiratory Journal 56 (4) 1150910; DOI: 10.1183/13993003.50910-2011 Published 15 October 2020

Author Correction

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“Official ERS technical standards: Global Lung Function Initiative reference values for the carbon monoxide transfer factor for Caucasians.” Sanja Stanojevic, Brian L. Graham, Brendan G. Cooper, Bruce R. Thompson, Kim W. Carter, Richard W. Francis and Graham L. Hall on behalf of the Global Lung Function Initiative T_LCO working group. Eur Respir J 2017; 50: 1700010.
European Respiratory Journal 56 (4) 1750010; DOI: 10.1183/13993003.50010-2017 Published 15 October 2020

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Table of Contents

Editorials

Task Force Report

Original Articles

Bronchiectasis

COPD

Asthma

Lung transplantation

Pulmonary infections

Pulmonary hypertension

Respiratory muscles

Dyspnoea

Paediatrics

Back to Basics

Agora

Research letters

Correspondence

Author Statement

Author Correction

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