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Table of Contents

01 September 2020; volume 56, issue 3

Editorials

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    Celebrating the ERS HERMES Self-Assessment Course
    Robert Primhak, Zuzana Tumova, Amy Auer, Daiana Stolz
    European Respiratory Journal 56 (3) 2002895; DOI: 10.1183/13993003.02895-2020 Published 3 September 2020
  • You have accessRestricted access
    ERS Scientific Working Group 09.04, “Psychologists and behavioural scientists”: the next step towards multidisciplinary respiratory care
    Andreas von Leupoldt, Lisa Jane Brighton, Jeannette Peters, Eleonora Volpato, Marieke Verkleij, Ann Hutchinson, Monique Heijmans, Ingeborg Farver-Vestergaard, Daniel Langer, Martijn A. Spruit on behalf of the ERS Scientific Working Group 09.04
    European Respiratory Journal 56 (3) 2001881; DOI: 10.1183/13993003.01881-2020 Published 17 September 2020
  • Open Access
    Pandemic treatments on trial: the bigger picture. N of many thinking in an N of one scenario
    Tom Kotsimbos, Marc Humbert
    European Respiratory Journal 56 (3) 2002281; DOI: 10.1183/13993003.02281-2020 Published 17 September 2020
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    Imaging risk in pulmonary arterial hypertension
    Roberto Badagliacca, Carmine Dario Vizza
    European Respiratory Journal 56 (3) 2002313; DOI: 10.1183/13993003.02313-2020 Published 24 September 2020
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    Carriers of a single CFTR mutation are asymptomatic: an evolving dogma?
    Clémence Martin, Pierre-Régis Burgel
    European Respiratory Journal 56 (3) 2002645; DOI: 10.1183/13993003.02645-2020 Published 10 September 2020
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    Intermittent regimens for tuberculosis treatment: Back to the Future?
    Jan-Willem C. Alffenaar, Simon Tiberi, Daniela M. Cirillo, Giovanni Battista Migliori
    European Respiratory Journal 56 (3) 2002510; DOI: 10.1183/13993003.02510-2020 Published 3 September 2020
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    Sarcoidosis in a time of pandemic
    Praveen Govender, Yvette C. Cozier
    European Respiratory Journal 56 (3) 2002376; DOI: 10.1183/13993003.02376-2020 Published 3 September 2020
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    ECMO support for viral induced cardiogenic shock: a bridge too far?
    Trevor J. Williams, Vincent Pellegrino
    European Respiratory Journal 56 (3) 2002129; DOI: 10.1183/13993003.02129-2020 Published 3 September 2020
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    Oscillometry: old physiology with a bright future
    Peter M.A. Calverley, Ramon Farré
    European Respiratory Journal 56 (3) 2001815; DOI: 10.1183/13993003.01815-2020 Published 10 September 2020

Task Force Report

  • Open Access
    COVID-19: guidance on palliative care from a European Respiratory Society international task force
    Daisy J.A. Janssen, Magnus Ekström, David C. Currow, Miriam J. Johnson, Matthew Maddocks, Anita K. Simonds, Thomy Tonia, Kristoffer Marsaa
    European Respiratory Journal 56 (3) 2002583; DOI: 10.1183/13993003.02583-2020 Published 3 September 2020

Original Articles

  • Pulmonary hypertension

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      A comprehensive echocardiographic method for risk stratification in pulmonary arterial hypertension
      Stefano Ghio, Valentina Mercurio, Federico Fortuni, Paul R. Forfia, Henning Gall, Ardeschir Ghofrani, Stephen C. Mathai, Jeremy A. Mazurek, Monica Mukherjee, Manuel Richter, Laura Scelsi, Paul M. Hassoun, Khodr Tello TAPSE in PAH investigators
      European Respiratory Journal 56 (3) 2000513; DOI: 10.1183/13993003.00513-2020 Published 24 September 2020
  • Lung structure and function

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      Normal spirometry predictive values for the Western Indian adult population
      Dhiraj Agarwal, Richard A. Parker, Hilary Pinnock, Sudipto Roy, Deesha Ghorpade, Sundeep Salvi, Parag Khatavkar, Sanjay Juvekar for the RESPIRE collaboration
      European Respiratory Journal 56 (3) 1902129; DOI: 10.1183/13993003.02129-2019 Published 17 September 2020
  • Cystic fibrosis

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      Morbidity and mortality in carriers of the cystic fibrosis mutation CFTR Phe508del in the general population
      Yunus Çolak, Børge G. Nordestgaard, Shoaib Afzal
      European Respiratory Journal 56 (3) 2000558; DOI: 10.1183/13993003.00558-2020 Published 10 September 2020
  • Infectious disease

    • Open Access
      Gene expression and in situ protein profiling of candidate SARS-CoV-2 receptors in human airway epithelial cells and lung tissue
      Jennifer A. Aguiar, Benjamin J-M. Tremblay, Michael J. Mansfield, Owen Woody, Briallen Lobb, Arinjay Banerjee, Abiram Chandiramohan, Nicholas Tiessen, Quynh Cao, Anna Dvorkin-Gheva, Spencer Revill, Matthew S. Miller, Christopher Carlsten, Louise Organ, Chitra Joseph, Alison John, Paul Hanson, Richard C. Austin, Bruce M. McManus, Gisli Jenkins, Karen Mossman, Kjetil Ask, Andrew C. Doxey, Jeremy A. Hirota
      European Respiratory Journal 56 (3) 2001123; DOI: 10.1183/13993003.01123-2020 Published 3 September 2020
  • Tuberculosis

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      The risk of multidrug- or rifampicin-resistance in males versus females with tuberculosis
      C. Finn McQuaid, Katherine C. Horton, Anna S. Dean, Gwenan M. Knight, Richard G. White
      European Respiratory Journal 56 (3) 2000626; DOI: 10.1183/13993003.00626-2020 Published 17 September 2020
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      Fully weekly antituberculosis regimen: a proof-of-concept study
      Fatma Kort, Laure Fournier Le Ray, Aurélie Chauffour, Vincent Jarlier, Nacer Lounis, Koen Andries, Alexandra Aubry, Lorenzo Guglielmetti, Nicolas Veziris
      European Respiratory Journal 56 (3) 1902502; DOI: 10.1183/13993003.02502-2019 Published 3 September 2020
  • Sarcoidosis

    • Open Access
      Risk of first and recurrent serious infection in sarcoidosis: a Swedish register-based cohort study
      Marios Rossides, Susanna Kullberg, Anders Eklund, Daniela Di Giuseppe, Johan Grunewald, Johan Askling, Elizabeth V. Arkema
      European Respiratory Journal 56 (3) 2000767; DOI: 10.1183/13993003.00767-2020 Published 3 September 2020
  • Critical care

    • Open Access
      Mechanical circulatory support in refractory cardiogenic shock due to influenza virus-related myocarditis
      Jan-Thorben Sieweke, Muharrem Akin, Sebastian Stetskamp, Christian Riehle, Danny Jonigk, Ulrike Flierl, Tobias J. Pfeffer, Valentin Hirsch, Jochen Dutzmann, Marius M. Hoeper, Christian Kühn, Johann Bauersachs, Andreas Schäfer
      European Respiratory Journal 56 (3) 2000925; DOI: 10.1183/13993003.00925-2020 Published 3 September 2020
  • COPD

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      Day-to-day variability of forced oscillatory mechanics for early detection of acute exacerbations in COPD
      Sabine C. Zimmermann, Jacqueline Huvanandana, Chinh D. Nguyen, Amy Bertolin, Joanna C. Watts, Alessandro Gobbi, Claude S. Farah, Matthew J. Peters, Raffaele L. Dellacà, Gregory G. King, Cindy Thamrin
      European Respiratory Journal 56 (3) 1901739; DOI: 10.1183/13993003.01739-2019 Published 10 September 2020
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      Autotitrating external positive end-expiratory airway pressure to abolish expiratory flow limitation during tidal breathing in patients with severe COPD: a physiological study
      Eui-Sik Suh, Pasquale Pompilio, Swapna Mandal, Peter Hill, Georgios Kaltsakas, Patrick B. Murphy, Robert Romano, John Moxham, Raffaele Dellaca, Nicholas Hart
      European Respiratory Journal 56 (3) 1902234; DOI: 10.1183/13993003.02234-2019 Published 10 September 2020
  • COPD and rehabilitation

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      Effects of downhill walking in pulmonary rehabilitation for patients with COPD: a randomised controlled trial
      Carlos Augusto Camillo, Christian Robert Osadnik, Chris Burtin, Stephanie Everaerts, Miek Hornikx, Heleen Demeyer, Matthias Loeckx, Fernanda Machado Rodrigues, Karen Maes, Ghislaine Gayan-Ramirez, Wim Janssens, Thierry Troosters
      European Respiratory Journal 56 (3) 2000639; DOI: 10.1183/13993003.00639-2020 Published 17 September 2020
  • COPD and basic science

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      Cigarette smoke-initiated autoimmunity facilitates sensitisation to elastin-induced COPD-like pathologies in mice
      Jie-Sen Zhou, Zhou-Yang Li, Xu-Chen Xu, Yun Zhao, Yong Wang, Hai-Pin Chen, Min Zhang, Yin-Fang Wu, Tian-Wen Lai, Chun-Hong Di, Ling-Ling Dong, Juan Liu, Nan-Xia Xuan, Chen Zhu, Yan-Ping Wu, Hua-Qiong Huang, Fu-Gui Yan, Wen Hua, Yi Wang, Wei-Ning Xiong, Hui Qiu, Tao Chen, Dong Weng, Hui-Ping Li, Xiaobo Zhou, Lie Wang, Fang Liu, Xin Lin, Song-Min Ying, Wen Li, Mitsuru Imamura, Mary E. Choi, Martin R. Stampfli, Augustine M.K. Choi, Zhi-Hua Chen, Hua-Hao Shen
      European Respiratory Journal 56 (3) 2000404; DOI: 10.1183/13993003.00404-2020 Published 3 September 2020
  • Asthma

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      SMART and as-needed therapies in mild-to-severe asthma: a network meta-analysis
      Paola Rogliani, Beatrice Ludovica Ritondo, Josuel Ora, Mario Cazzola, Luigino Calzetta
      European Respiratory Journal 56 (3) 2000625; DOI: 10.1183/13993003.00625-2020 Published 10 September 2020
    • Open Access
      Epigenome-wide association study of DNA methylation and adult asthma in the Agricultural Lung Health Study
      Thanh T. Hoang, Sinjini Sikdar, Cheng-Jian Xu, Mi Kyeong Lee, Jonathan Cardwell, Erick Forno, Medea Imboden, Ayoung Jeong, Anne-Marie Madore, Cancan Qi, Tianyuan Wang, Brian D. Bennett, James M. Ward, Christine G. Parks, Laura E. Beane-Freeman, Debra King, Alison Motsinger-Reif, David M. Umbach, Annah B. Wyss, David A. Schwartz, Juan C. Celedón, Catherine Laprise, Carole Ober, Nicole Probst-Hensch, Ivana V. Yang, Gerard H. Koppelman, Stephanie J. London
      European Respiratory Journal 56 (3) 2000217; DOI: 10.1183/13993003.00217-2020 Published 3 September 2020
  • Asthma and basic science

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      Innate lymphoid cells in isocyanate-induced asthma: role of microRNA-155
      Evy E. Blomme, Sharen Provoost, Erica Bazzan, Hannelore P. Van Eeckhoutte, Mirjam P. Roffel, Lore Pollaris, Annelies Bontinck, Matteo Bonato, Louise Vandenbroucke, Fien Verhamme, Guy F. Joos, Manuel G. Cosio, Jeroen A. J. Vanoirbeek, Guy G. Brusselle, Marina Saetta, Tania Maes
      European Respiratory Journal 56 (3) 1901289; DOI: 10.1183/13993003.01289-2019 Published 24 September 2020
  • Lung transplantation

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      Late-onset “acute fibrinous and organising pneumonia” impairs long-term lung allograft function and survival
      Arno Vanstapel, Stijn E. Verleden, Birgit Weynand, Eric Verbeken, Laurens De Sadeleer, Bart M. Vanaudenaerde, Geert M. Verleden, Robin Vos the Leuven Lung Transplant Group
      European Respiratory Journal 56 (3) 1902292; DOI: 10.1183/13993003.02292-2019 Published 3 September 2020

Review

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    Artificial intelligence techniques in asthma: a systematic review and critical appraisal of the existing literature
    Konstantinos P. Exarchos, Maria Beltsiou, Chainti-Antonella Votti, Konstantinos Kostikas
    European Respiratory Journal 56 (3) 2000521; DOI: 10.1183/13993003.00521-2020 Published 3 September 2020

Back to Basics

  • Open Access
    Pathogenesis of COVID-19-induced ARDS: implications for an ageing population
    Manuel A. Torres Acosta, Benjamin D. Singer
    European Respiratory Journal 56 (3) 2002049; DOI: 10.1183/13993003.02049-2020 Published 24 September 2020

Agora

  • Research letters

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      Extrafine triple therapy in patients with asthma and persistent airflow limitation
      Dave Singh, Johann Christian Virchow, Giorgio Walter Canonica, Andrea Vele, Maxim Kots, George Georges, Alberto Papi
      European Respiratory Journal 56 (3) 2000476; DOI: 10.1183/13993003.00476-2020 Published 24 September 2020
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      Effect of history of tuberculosis on specificity of Xpert MTB/RIF
      Frederick Haraka, Samuel G. Schumacher, Amanda Ross, Anna Mantsoki, Sebastien Gagneux, Klaus Reither, Claudia M. Denkinger
      European Respiratory Journal 56 (3) 2000343; DOI: 10.1183/13993003.00343-2020 Published 24 September 2020
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      Effect of long-acting β-agonist on bronchodilator response in children with asthma
      Jessica Taytard, Camille Aupiais, Sophie Jovien, Jessica Assouline Kabla, Noémie Haziot, Marilyn Fuger, Corinne Alberti, Nicole Beydon
      European Respiratory Journal 56 (3) 1902010; DOI: 10.1183/13993003.02010-2019 Published 24 September 2020
    • Open Access
      Elevated ACE-2 expression in the olfactory neuroepithelium: implications for anosmia and upper respiratory SARS-CoV-2 entry and replication
      Mengfei Chen, Wenjuan Shen, Nicholas R. Rowan, Heather Kulaga, Alexander Hillel, Murugappan Ramanathan Jr, Andrew P. Lane
      European Respiratory Journal 56 (3) 2001948; DOI: 10.1183/13993003.01948-2020 Published 24 September 2020
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      Ventilatory demand–capacity imbalance during incremental exercise in COPD: an in silico perspective
      J. Alberto Neder
      European Respiratory Journal 56 (3) 2000495; DOI: 10.1183/13993003.00495-2020 Published 17 September 2020
    • Open Access
      Iron bioavailability and cardiopulmonary function during ascent to very high altitude
      David A. Holdsworth, Matthew C. Frise, Josh Bakker-Dyos, Christopher Boos, Keith L. Dorrington, David Woods, Adrian Mellor, Peter A. Robbins
      European Respiratory Journal 56 (3) 1902285; DOI: 10.1183/13993003.02285-2019 Published 17 September 2020
    • Open Access
      Socioeconomic correlates of SARS-CoV-2 and influenza H1N1 outbreaks
      Jan Christian Kaiser, Georgios T. Stathopoulos
      European Respiratory Journal 56 (3) 2001400; DOI: 10.1183/13993003.01400-2020 Published 17 September 2020
    • Open Access
      Comparison of severity scores for COVID-19 patients with pneumonia: a retrospective study
      Guohui Fan, Chao Tu, Fei Zhou, Zhibo Liu, Yeming Wang, Bin Song, Xiaoying Gu, Yimin Wang, Yuan Wei, Hui Li, Xudong Wu, Jiuyang Xu, Shengjin Tu, Yi Zhang, Wenjuan Wu, Bin Cao
      European Respiratory Journal 56 (3) 2002113; DOI: 10.1183/13993003.02113-2020 Published 10 September 2020
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      Circulating RNA differences between patients with stable and progressive idiopathic pulmonary fibrosis
      Britt Clynick, Helen E. Jo, Tamera J. Corte, Ian N. Glaspole, Christopher Grainge, Peter M.A. Hopkins, Paul N. Reynolds, Sally Chapman, E. Haydn Walters, Christopher Zappala, Gregory J. Keir, Wendy A. Cooper, Annabelle M. Mahar, Samantha Ellis, Nicole S. Goh, Svetlana Baltic, Marisa Ryan, Dino B.A. Tan, Yuben P. Moodley
      European Respiratory Journal 56 (3) 1902058; DOI: 10.1183/13993003.02058-2019 Published 10 September 2020
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      The impact of different antibiotic treatment regimens on mortality in Mycobacterium avium complex pulmonary disease: a population-based cohort study
      Sarah K. Brode, Hannah Chung, Michael A. Campitelli, Jeffrey C. Kwong, Rinku Sutradhar, Alex Marchand-Austin, Kevin L. Winthrop, Frances B. Jamieson, Theodore K. Marras
      European Respiratory Journal 56 (3) 1901875; DOI: 10.1183/13993003.01875-2019 Published 10 September 2020
    • You have accessRestricted access
      Evaluation of pulmonary hypertension by right heart catheterisation: does timing matter?
      Athiththan Yogeswaran, Manuel Jonas Richter, Natascha Sommer, Hossein Ardeschir Ghofrani, Werner Seeger, Henning Gall, Khodr Tello
      European Respiratory Journal 56 (3) 1901892; DOI: 10.1183/13993003.01892-2019 Published 3 September 2020
    • Open Access
      Initial combination therapy of macitentan and tadalafil in pulmonary arterial hypertension
      Olivier Sitbon, Vincent Cottin, Matthieu Canuet, Pierre Clerson, Virginie Gressin, Loïc Perchenet, Laurent Bertoletti, Hélène Bouvaist, François Picard, Grégoire Prévot, Emmanuel Bergot, Gérald Simonneau
      European Respiratory Journal 56 (3) 2000673; DOI: 10.1183/13993003.00673-2020 Published 3 September 2020
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      Ozone exposure leads to changes in airway permeability, microbiota and metabolome: a randomised, double-blind, crossover trial
      Yue Niu, Renjie Chen, Cuiping Wang, Weidong Wang, Jing Jiang, Weidong Wu, Jing Cai, Zhuohui Zhao, Xiaohui Xu, Haidong Kan
      European Respiratory Journal 56 (3) 2000165; DOI: 10.1183/13993003.00165-2020 Published 3 September 2020
  • Correspondence

    • Open Access
      JAK inhibitors in COVID-19: the need for vigilance regarding increased inherent thrombotic risk
      Puja Mehta, Coziana Ciurtin, Marie Scully, Marcel Levi, Rachel C. Chambers
      European Respiratory Journal 56 (3) 2001919; DOI: 10.1183/13993003.01919-2020 Published 24 September 2020
    • Open Access
      Insight into the impact of the COVID-19 epidemic on tuberculosis burden in China
      Hongguang Chen, Konglai Zhang
      European Respiratory Journal 56 (3) 2002710; DOI: 10.1183/13993003.02710-2020 Published 24 September 2020
    • Open Access
      Similarities between COVID-19 and anti-MDA5 syndrome: what can we learn for better care?
      Margherita Giannini, Mickael Ohana, Benoit Nespola, Giovanni Zanframundo, Bernard Geny, Alain Meyer
      European Respiratory Journal 56 (3) 2001618; DOI: 10.1183/13993003.01618-2020 Published 24 September 2020
    • Open Access
      Antibiotics for paediatric community-acquired pneumonia in resource-constrained settings
      Amy Sarah Ginsburg, Keith P. Klugman
      European Respiratory Journal 56 (3) 2002773; DOI: 10.1183/13993003.02773-2020 Published 17 September 2020
    • Open Access
      Characteristics and outcomes of health and social care workers testing positive for SARS-CoV-2 in the Tayside region of Scotland
      Moneeza K. Siddiqui, Benjamin Parcell, Sarah Allstaff, Colin Palmer, James D. Chalmers, Samira Bell
      European Respiratory Journal 56 (3) 2002568; DOI: 10.1183/13993003.02568-2020 Published 17 September 2020
    • Open Access
      SARS-CoV-2 disrupts clinical research: the role of a rare disease-specific trial network
      Silke van Koningsbruggen-Rietschel, Fiona Dunlevy, Veerle Bulteel, Damian G. Downey, Lieven Dupont
      European Respiratory Journal 56 (3) 2002114; DOI: 10.1183/13993003.02114-2020 Published 17 September 2020
    • Open Access
      COVID-19 prediction models should adhere to methodological and reporting standards
      Gary S. Collins, Maarten van Smeden, Richard D. Riley
      European Respiratory Journal 56 (3) 2002643; DOI: 10.1183/13993003.02643-2020 Published 10 September 2020
    • Open Access
      Reply to “COVID-19 prediction models should adhere to methodological and reporting standards”
      Guangyao Wu, Henry C. Woodruff, Avishek Chatterjee, Philippe Lambin
      European Respiratory Journal 56 (3) 2002918; DOI: 10.1183/13993003.02918-2020 Published 10 September 2020
    • Open Access
      Rationale and significance of patient selection in awake prone positioning for COVID-19 pneumonia
      Ching-Feng Huang, Chee Kiang Tay, Ya-Fang Zhuang, Jiaxuan Liu, Duu Wen Sewa
      European Respiratory Journal 56 (3) 2002173; DOI: 10.1183/13993003.02173-2020 Published 10 September 2020
    • Open Access
      Rationale and significance of patient selection in awake prone positioning for COVID-19 pneumonia
      Ziqin Ng, Woo Chiao Tay, Choon Heng Benjamin Ho
      European Respiratory Journal 56 (3) 2002571; DOI: 10.1183/13993003.02571-2020 Published 10 September 2020
    • You have accessRestricted access
      Systemic effects of fluticasone on blood eosinophils in bronchiectasis
      Brian Lipworth, Rory Chan, Chris RuiWen Kuo
      European Respiratory Journal 56 (3) 2002005; DOI: 10.1183/13993003.02005-2020 Published 3 September 2020
    • You have accessRestricted access
      Blood eosinophils do not predict inhaled budesonide response in bronchiectasis
      Stefano Aliberti, Giovanni Sotgiu, Miguel-Angel Martinez Garcia
      European Respiratory Journal 56 (3) 2002210; DOI: 10.1183/13993003.02210-2020 Published 3 September 2020
    • Open Access
      Potential of regulatory T-cell-based therapies in the management of severe COVID-19
      Emmanuel Stephen-Victor, Mrinmoy Das, Anupama Karnam, Bruno Pitard, Jean-François Gautier, Jagadeesh Bayry
      European Respiratory Journal 56 (3) 2002182; DOI: 10.1183/13993003.02182-2020 Published 3 September 2020
    • Open Access
      Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2
      Hai-Jun Yang, Yan-Mei Zhang, Min Yang, Xing Huang
      European Respiratory Journal 56 (3) 2002439; DOI: 10.1183/13993003.02439-2020 Published 24 September 2020
    • Open Access
      Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2
      Rong-Hui Du, Li-Rong Liang, Cheng-Qing Yang, Wen Wang, Tan-Ze Cao, Ming Li, Guang-Yun Guo, Juan Du, Chun-Lan Zheng, Qi Zhu, Ming Hu, Xu-Yan Li, Peng Peng, Huan-Zhong Shi
      European Respiratory Journal 56 (3) 2002961; DOI: 10.1183/13993003.02961-2020 Published 24 September 2020

Author correction

  • You have accessRestricted access
    “Predictors of mortality for patients with COVID-19 pneumonia caused by SARS-CoV-2: a prospective cohort study.” Rong-Hui Du, Li-Rong Liang, Cheng-Qing Yang, Wen Wang, Tan-Ze Cao, Ming Li, Guang-Yun Guo, Juan Du, Chun-Lan Zheng, Qi Zhu, Ming Hu, Xu-Yan Li, Peng Peng and Huan-Zhong Shi. Eur Respir J 2020; 55: 2000524.
    European Respiratory Journal 56 (3) 2050524; DOI: 10.1183/13993003.50524-2020 Published 24 September 2020
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European Respiratory Journal: 56 (3)
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    • Pulmonary hypertension
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    • COPD and basic science
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