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Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19

Margot Combet, Arthur Pavot, Laurent Savale, Marc Humbert, Xavier Monnet
European Respiratory Journal 2020 56: 2001808; DOI: 10.1183/13993003.01808-2020
Margot Combet
1AP-HP, Service de médecine intensive-réanimation, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France
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Arthur Pavot
1AP-HP, Service de médecine intensive-réanimation, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France
2Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France
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  • ORCID record for Arthur Pavot
  • For correspondence: pavot.arthur@gmail.com
Laurent Savale
2Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France
3AP-HP, Service de pneumologie et soins intensifs respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France
4INSERM UMR_S 999, Hôpital Marie-Lannelongue, Le Plessis-Robinson, France
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Marc Humbert
2Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France
3AP-HP, Service de pneumologie et soins intensifs respiratoires, Centre de Référence de l'Hypertension Pulmonaire, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France
4INSERM UMR_S 999, Hôpital Marie-Lannelongue, Le Plessis-Robinson, France
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  • ORCID record for Marc Humbert
Xavier Monnet
1AP-HP, Service de médecine intensive-réanimation, Hôpital de Bicêtre, Le Kremlin-Bicêtre, France
2Université Paris-Saclay, Faculté de Médecine, Le Kremlin-Bicêtre, France
4INSERM UMR_S 999, Hôpital Marie-Lannelongue, Le Plessis-Robinson, France
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    a) Initial CT scan: images show extensive ground-glass opacities in both lungs with subpleural predominance affecting 50–75% of lung parenchyma, as well as condensation in the right lower lobe. b) Control CT imaging at day-10 : axial CT images show extensive honeycombing cysts associated with septal thickening, with subpleural predominance (where ground-glass opacities had initially been observed, notably in the right lower and upper lobes), with associated traction bronchiectasis. Pneumomediastinum also developed. There was no sign of pulmonary embolism.

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Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19
Margot Combet, Arthur Pavot, Laurent Savale, Marc Humbert, Xavier Monnet
European Respiratory Journal Aug 2020, 56 (2) 2001808; DOI: 10.1183/13993003.01808-2020

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Rapid onset honeycombing fibrosis in spontaneously breathing patient with COVID-19
Margot Combet, Arthur Pavot, Laurent Savale, Marc Humbert, Xavier Monnet
European Respiratory Journal Aug 2020, 56 (2) 2001808; DOI: 10.1183/13993003.01808-2020
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