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Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the INSIGHTS-IPF registry

Jürgen Behr, Antje Prasse, Hubert Wirtz, Dirk Koschel, David Pittrow, Matthias Held, Jens Klotsche, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F. Meyer, Joachim Kirschner, Sven Gläser, Nicolas Kahn, Tobias Welte, Claus Neurohr, Martin Schwaiblmair, Thomas Bahmer, Tim Oqueka, Marion Frankenberger, Michael Kreuter
European Respiratory Journal 2020 56: 1902279; DOI: 10.1183/13993003.02279-2019
Jürgen Behr
1Medizinische Klinik und Poliklinik V, LMU Klinikum, University of Munich, Munich, Germany
2Comprehensive Pneumology Center (CPC), Lungenforschungsambulanz, LMU Klinikum und Helmholtz Zentrum, Munich, Germany
3Asklepios Fachkliniken, München-Gauting, Germany
4German Center for Lung Research (DZL), Germany
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  • For correspondence: juergen.behr@med.uni-muenchen.de
Antje Prasse
4German Center for Lung Research (DZL), Germany
5Klinik für Pneumologie, Medizinische Hochschule Hannover, Hannover, Germany
6Fraunhofer Institute ITEM, Hannover, Germany
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  • ORCID record for Antje Prasse
Hubert Wirtz
7Abteilung für Pneumologie, Department Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig AöR, Leipzig, Germany
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Dirk Koschel
8Zentrum für Pneumologie, Fachkrankenhaus Coswig, Coswig, Germany
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David Pittrow
9Institut für Klinische Pharmakologie, Medizinische Fakultät, Technische Universität Dresden, Dresden, Germany
10GWT-TUD GmbH, Pharmacoepidemiology, Dresden, Germany
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  • ORCID record for David Pittrow
Matthias Held
11Department of Internal Medicine, Respiratory Medicine and Ventilatory Support, Medical Mission Hospital, Central Clinic, Würzburg, Germany
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Jens Klotsche
12Epidemiologie, Deutsches Rheuma-Forschungszentrum, Berlin, Germany
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Stefan Andreas
13Lungenfachklinik Immenhausen und Universitätsmedizin Göttingen, Kardiologie und Pneumologie, Göttingen, Germany
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  • ORCID record for Stefan Andreas
Martin Claussen
4German Center for Lung Research (DZL), Germany
14LungenClinic Grosshansdorf, Großhansdorf, Germany
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Christian Grohé
15Klinik für Pneumologie – ELK, Berlin Buch, Berlin, Germany
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Henrike Wilkens
16Klinik für Innere Medizin V, Pneumologie, Universitätsklinikum, Universitätskliniken des Saarlandes, Homburg, Germany
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Lars Hagmeyer
17Krankenhaus Bethanien, Klinik für Pneumologie und Allergologie, Zentrum für Schlaf- und Beatmungsmedizin; Institut für Pneumologie, Universität zu Köln, Solingen, Germany
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Dirk Skowasch
18Medizinische Klinik und Poliklinik II, Universitätsklinikum, Bonn, Germany
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Joachim F. Meyer
19Lungenzentrum München, LZM Bogenhausen-Harlaching, Städtisches Klinikum München GmbH, Munich, Germany
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Joachim Kirschner
20Center for Internal Medical Studies CIMS, Bamberg, Germany
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Sven Gläser
21Klinik und Poliklinik für Innere Medizin B, Forschungsbereich Pneumologie und Pneumologische Epidemiologie, Universitätsmedizin Greifswald, Greifswald, Germany
22Klinik für Innere Medizin – Pneumologie und Infektiologie, Vivantes Klinikum Neukölln und Spandau, Berlin, Germany
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Nicolas Kahn
23Center for Interstitial and Rare Lung Diseases, Pneumology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany
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Tobias Welte
4German Center for Lung Research (DZL), Germany
5Klinik für Pneumologie, Medizinische Hochschule Hannover, Hannover, Germany
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Claus Neurohr
24Abteilung für Pneumologie und Beatmungsmedizin, Klinik Schillerhöhe, Gerlingen, Germany
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Martin Schwaiblmair
25Medizinische Klinik, Universitätsklinikum, Augsburg, Germany
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Thomas Bahmer
14LungenClinic Grosshansdorf, Großhansdorf, Germany
26Abteilung für Innere Medizin I, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany
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Tim Oqueka
27II Medizinische Klinik und Poliklinik, Universitätsklinikum, Hamburg-Eppendorf, Germany
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Marion Frankenberger
2Comprehensive Pneumology Center (CPC), Lungenforschungsambulanz, LMU Klinikum und Helmholtz Zentrum, Munich, Germany
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Michael Kreuter
4German Center for Lung Research (DZL), Germany
23Center for Interstitial and Rare Lung Diseases, Pneumology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany
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Article Information

vol. 56 no. 2
DOI 
https://doi.org/10.1183/13993003.02279-2019
PubMed 
32381492

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received November 26, 2019
  • Accepted April 7, 2020
  • Published online August 13, 2020.

Article Versions

  • previous version (May 7, 2020 - 09:57).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©ERS 2020

Author Information

  1. Jürgen Behr1,2,3,4⇑,
  2. Antje Prasse4,5,6,
  3. Hubert Wirtz7,
  4. Dirk Koschel8,
  5. David Pittrow9,10,
  6. Matthias Held11,
  7. Jens Klotsche12,
  8. Stefan Andreas13,
  9. Martin Claussen4,14,
  10. Christian Grohé15,
  11. Henrike Wilkens16,
  12. Lars Hagmeyer17,
  13. Dirk Skowasch18,
  14. Joachim F. Meyer19,
  15. Joachim Kirschner20,
  16. Sven Gläser21,22,
  17. Nicolas Kahn23,
  18. Tobias Welte4,5,
  19. Claus Neurohr24,
  20. Martin Schwaiblmair25,
  21. Thomas Bahmer14,26,
  22. Tim Oqueka27,
  23. Marion Frankenberger2 and
  24. Michael Kreuter4,23
  1. 1Medizinische Klinik und Poliklinik V, LMU Klinikum, University of Munich, Munich, Germany
  2. 2Comprehensive Pneumology Center (CPC), Lungenforschungsambulanz, LMU Klinikum und Helmholtz Zentrum, Munich, Germany
  3. 3Asklepios Fachkliniken, München-Gauting, Germany
  4. 4German Center for Lung Research (DZL), Germany
  5. 5Klinik für Pneumologie, Medizinische Hochschule Hannover, Hannover, Germany
  6. 6Fraunhofer Institute ITEM, Hannover, Germany
  7. 7Abteilung für Pneumologie, Department Innere Medizin, Neurologie und Dermatologie, Universitätsklinikum Leipzig AöR, Leipzig, Germany
  8. 8Zentrum für Pneumologie, Fachkrankenhaus Coswig, Coswig, Germany
  9. 9Institut für Klinische Pharmakologie, Medizinische Fakultät, Technische Universität Dresden, Dresden, Germany
  10. 10GWT-TUD GmbH, Pharmacoepidemiology, Dresden, Germany
  11. 11Department of Internal Medicine, Respiratory Medicine and Ventilatory Support, Medical Mission Hospital, Central Clinic, Würzburg, Germany
  12. 12Epidemiologie, Deutsches Rheuma-Forschungszentrum, Berlin, Germany
  13. 13Lungenfachklinik Immenhausen und Universitätsmedizin Göttingen, Kardiologie und Pneumologie, Göttingen, Germany
  14. 14LungenClinic Grosshansdorf, Großhansdorf, Germany
  15. 15Klinik für Pneumologie – ELK, Berlin Buch, Berlin, Germany
  16. 16Klinik für Innere Medizin V, Pneumologie, Universitätsklinikum, Universitätskliniken des Saarlandes, Homburg, Germany
  17. 17Krankenhaus Bethanien, Klinik für Pneumologie und Allergologie, Zentrum für Schlaf- und Beatmungsmedizin; Institut für Pneumologie, Universität zu Köln, Solingen, Germany
  18. 18Medizinische Klinik und Poliklinik II, Universitätsklinikum, Bonn, Germany
  19. 19Lungenzentrum München, LZM Bogenhausen-Harlaching, Städtisches Klinikum München GmbH, Munich, Germany
  20. 20Center for Internal Medical Studies CIMS, Bamberg, Germany
  21. 21Klinik und Poliklinik für Innere Medizin B, Forschungsbereich Pneumologie und Pneumologische Epidemiologie, Universitätsmedizin Greifswald, Greifswald, Germany
  22. 22Klinik für Innere Medizin – Pneumologie und Infektiologie, Vivantes Klinikum Neukölln und Spandau, Berlin, Germany
  23. 23Center for Interstitial and Rare Lung Diseases, Pneumology, Thoraxklinik, University of Heidelberg, Heidelberg, Germany
  24. 24Abteilung für Pneumologie und Beatmungsmedizin, Klinik Schillerhöhe, Gerlingen, Germany
  25. 25Medizinische Klinik, Universitätsklinikum, Augsburg, Germany
  26. 26Abteilung für Innere Medizin I, Universitätsklinikum Schleswig-Holstein, Campus Kiel, Kiel, Germany
  27. 27II Medizinische Klinik und Poliklinik, Universitätsklinikum, Hamburg-Eppendorf, Germany
  1. Jürgen Behr, Medizinische Klinik und Poliklinik V, LMU Klinikum, University of Munich, Marchionstraße 15, 81377, München, Germany, E-mail: juergen.behr{at}med.uni-muenchen.de
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Funding

  • Boehringer Ingelheim

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Article usage: May 2020 to March 2021

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Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the INSIGHTS-IPF registry
Jürgen Behr, Antje Prasse, Hubert Wirtz, Dirk Koschel, David Pittrow, Matthias Held, Jens Klotsche, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F. Meyer, Joachim Kirschner, Sven Gläser, Nicolas Kahn, Tobias Welte, Claus Neurohr, Martin Schwaiblmair, Thomas Bahmer, Tim Oqueka, Marion Frankenberger, Michael Kreuter
European Respiratory Journal Aug 2020, 56 (2) 1902279; DOI: 10.1183/13993003.02279-2019

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Survival and course of lung function in the presence or absence of antifibrotic treatment in patients with idiopathic pulmonary fibrosis: long-term results of the INSIGHTS-IPF registry
Jürgen Behr, Antje Prasse, Hubert Wirtz, Dirk Koschel, David Pittrow, Matthias Held, Jens Klotsche, Stefan Andreas, Martin Claussen, Christian Grohé, Henrike Wilkens, Lars Hagmeyer, Dirk Skowasch, Joachim F. Meyer, Joachim Kirschner, Sven Gläser, Nicolas Kahn, Tobias Welte, Claus Neurohr, Martin Schwaiblmair, Thomas Bahmer, Tim Oqueka, Marion Frankenberger, Michael Kreuter
European Respiratory Journal Aug 2020, 56 (2) 1902279; DOI: 10.1183/13993003.02279-2019
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