Age years | 63±11 |
Female gender % | 82 |
BMI kg·m−2 | 31.4±7.8 |
Aetiology | |
Non-CTD associated PAH | 40 |
Idiopathic | 39 |
HIV associated | 1 |
CTD associated PAH | 42 |
Systemic sclerosis spectrum | 39 |
Rheumatoid arthritis | 2 |
Systemic lupus erythematosus | 1 |
Comorbidities | |
Diabetes mellitus | 20 (24) |
Hypertension | 45 (55) |
Dyslipidaemia | 36 (44) |
Ischaemic heart disease | 22 (27) |
Peripheral vascular disease | 5 (6) |
Current smoker | 3 (4) |
Ex-smoker | 26 (32) |
OSA | 20 (24) |
Baseline haemodynamics | |
Mean PAP mmHg | 27 (25–30) |
PAWP mmHg | 13 (11–14) |
PVR Wood units | 2.2 (1.9–2.7) |
Cardiac output L·min−1 | 6.7 (5.8–7.9) |
Cardiac index L·min−1·m−2 | 3.55 (3.1–4.2) |
RAP mmHg | 8.0 (5.2–10.0) |
Mean SAP mmHg | 98 (83–106) |
SVR dynes·sec·cm−5 | 1078 (852–1240) |
HR beats·min−1 | 72 (67–87) |
Baseline 6MWD m | 352 (280–416) |
PFT | |
FEV1 % predicted | 91 (75–96) |
FVC % predicted | 90 (81–105) |
TLC % predicted | 93 (80–98) |
DLCO % predicted | 53 (45–62) |
NYHA functional class | |
1 | 1 (1) |
2 | 19 (23) |
3 | 60 (73) |
4 | 2 (3) |