Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
    • Open access
    • COVID-19 submission information
  • Alerts
  • Podcasts
  • Subscriptions

Human lipopolysaccharide models provide mechanistic and therapeutic insights into systemic and pulmonary inflammation

Daniel Brooks, Laura C. Barr, Sarah Wiscombe, Daniel F. McAuley, A. John Simpson, Anthony J. Rostron
European Respiratory Journal 2020 56: 1901298; DOI: 10.1183/13993003.01298-2019
Daniel Brooks
1Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Laura C. Barr
2Dept of Respiratory Medicine, Royal Infirmary of Edinburgh, Edinburgh, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sarah Wiscombe
1Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Daniel F. McAuley
3School of Medicine, Dentistry and Biomedical Sciences, Institute for Health Sciences, Wellcome-Wolfson Institute for Experimental Medicine, Belfast, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Daniel F. McAuley
A. John Simpson
1Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. John Simpson
Anthony J. Rostron
1Institute of Cellular Medicine, Newcastle University, Newcastle Upon Tyne, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Anthony J. Rostron
  • For correspondence: anthony.rostron@newcastle.ac.uk
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

Inflammation is a key feature in the pathogenesis of sepsis and acute respiratory distress syndrome (ARDS). Sepsis and ARDS continue to be associated with high mortality. A key contributory factor is the rudimentary understanding of the early events in pulmonary and systemic inflammation in humans, which are difficult to study in clinical practice, as they precede the patient's presentation to medical services. Lipopolysaccharide (LPS), a constituent of the outer membrane of Gram-negative bacteria, is a trigger of inflammation and the dysregulated host response in sepsis. Human LPS models deliver a small quantity of LPS to healthy volunteers, triggering an inflammatory response and providing a window to study early inflammation in humans. This allows biological/mechanistic insights to be made and new therapeutic strategies to be tested in a controlled, reproducible environment from a defined point in time. We review the use of human LPS models, focussing on the underlying mechanistic insights that have been gained by studying the response to intravenous and pulmonary LPS challenge. We discuss variables that may influence the response to LPS before considering factors that should be considered when designing future human LPS studies.

Abstract

Human lipopolysaccharide challenge models are a useful adjunct to clinical studies in refining understanding of the host innate immune response to help identify therapeutic targets in an attempt to improve outcomes in critical illness https://bit.ly/3aiCmrx

Footnotes

  • Conflict of interest: D. Brooks has nothing to disclose.

  • Conflict of interest: L.C. Barr has nothing to disclose.

  • Conflict of interest: S. Wiscombe has nothing to disclose.

  • Conflict of interest: D.F. McAuley reports personal fees for consultancy from Peptinnovate, Bayer, GlaxoSmithKline, Boehringer Ingelheim and SOBI, grants from NIHR, Wellcome Trust and other funders, institutional payments for undertaking bronchoscopy from GlaxoSmithKline, outside the submitted work; and has a patent for novel treatment for ARDS issued to Queen's University Belfast.

  • Conflict of interest: A.J. Simpson has nothing to disclose.

  • Conflict of interest: A.J. Rostron has nothing to disclose.

  • Received July 1, 2019.
  • Accepted March 18, 2020.
  • Copyright ©ERS 2020
https://www.ersjournals.com/user-licence
View Full Text

ERS Members

myERS - ERS members : log in with your myERS username and password.

INDIVIDUALS

Log in Login as an individual user.

Forgot your username or password?

LIBRARY USERS

Log in through your institution

If your library has a subscription, you may already be logged in via your IP address. Otherwise you may be able to log in via one of the following routes.
You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.
If you think you should have access, please contact your librarian or email journals@ersnet.org

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.
PreviousNext
Back to top
View this article with LENS
Vol 56 Issue 1 Table of Contents
European Respiratory Journal: 56 (1)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Human lipopolysaccharide models provide mechanistic and therapeutic insights into systemic and pulmonary inflammation
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Print
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Human lipopolysaccharide models provide mechanistic and therapeutic insights into systemic and pulmonary inflammation
Daniel Brooks, Laura C. Barr, Sarah Wiscombe, Daniel F. McAuley, A. John Simpson, Anthony J. Rostron
European Respiratory Journal Jul 2020, 56 (1) 1901298; DOI: 10.1183/13993003.01298-2019

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Human lipopolysaccharide models provide mechanistic and therapeutic insights into systemic and pulmonary inflammation
Daniel Brooks, Laura C. Barr, Sarah Wiscombe, Daniel F. McAuley, A. John Simpson, Anthony J. Rostron
European Respiratory Journal Jul 2020, 56 (1) 1901298; DOI: 10.1183/13993003.01298-2019
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
    • Abstract
    • Introduction
    • Methods
    • Intravenous LPS model
    • Respiratory LPS models
    • Challenges and limitations of human LPS models
    • Future considerations
    • Shareable PDF
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Diagnosis of CTEPH after acute pulmonary embolism
  • Clinical considerations in individuals with AAT PI*SZ genotype
Show more Reviews

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2021 by the European Respiratory Society