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Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19

Maroun Khoury, Jimena Cuenca, Fernanda F. Cruz, Fernando E. Figueroa, Patricia R.M. Rocco, Daniel J. Weiss
European Respiratory Journal 2020 55: 2000858; DOI: 10.1183/13993003.00858-2020
Maroun Khoury
1Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
2Cells for Cells and consorcio Regenero, Chilean Consortium for Regenerative Medicine, Santiago, Chile
6M. Khoury and D.J. Weiss contributed equally as lead authors of the study
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  • For correspondence: mkhoury@uandes.cl
Jimena Cuenca
1Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
2Cells for Cells and consorcio Regenero, Chilean Consortium for Regenerative Medicine, Santiago, Chile
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Fernanda F. Cruz
3Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
4National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil
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Fernando E. Figueroa
1Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
2Cells for Cells and consorcio Regenero, Chilean Consortium for Regenerative Medicine, Santiago, Chile
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Patricia R.M. Rocco
3Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
4National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil
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Daniel J. Weiss
5Dept of Medicine, University of Vermont, Burlington, VT, USA
6M. Khoury and D.J. Weiss contributed equally as lead authors of the study
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Article Information

vol. 55 no. 6
DOI 
https://doi.org/10.1183/13993003.00858-2020
PubMed 
32265310

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received March 25, 2020
  • Accepted April 3, 2020
  • Published online June 4, 2020.

Article Versions

  • previous version (April 7, 2020 - 03:17).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©ERS 2020 This version is distributed under the terms of the Creative Commons Attribution Non-Commercial Licence 4.0.

Author Information

  1. Maroun Khoury1,2,6⇑,
  2. Jimena Cuenca1,2,
  3. Fernanda F. Cruz3,4,
  4. Fernando E. Figueroa1,2,
  5. Patricia R.M. Rocco3,4 and
  6. Daniel J. Weiss5,6
  1. 1Laboratory of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de los Andes, Santiago, Chile
  2. 2Cells for Cells and consorcio Regenero, Chilean Consortium for Regenerative Medicine, Santiago, Chile
  3. 3Laboratory of Pulmonary Investigation, Carlos Chagas Filho Institute of Biophysics, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
  4. 4National Institute of Science and Technology for Regenerative Medicine, Rio de Janeiro, Brazil
  5. 5Dept of Medicine, University of Vermont, Burlington, VT, USA
  6. 6M. Khoury and D.J. Weiss contributed equally as lead authors of the study
  1. Maroun Khoury, Division of Nano-Regenerative Medicine, Faculty of Medicine, Universidad de los Andes, Av. La Plaza 2501, Las Condes, Chile. E-mail: mkhoury{at}uandes.cl
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Funding

  • Comisión Nacional de Investigación Científica y Tecnológica

    FONDEF 2016, IT16I10084

Article usage

Article usage: April 2020 to January 2021

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Vol 55 Issue 6 Table of Contents
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Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19
Maroun Khoury, Jimena Cuenca, Fernanda F. Cruz, Fernando E. Figueroa, Patricia R.M. Rocco, Daniel J. Weiss
European Respiratory Journal Jun 2020, 55 (6) 2000858; DOI: 10.1183/13993003.00858-2020

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Current status of cell-based therapies for respiratory virus infections: applicability to COVID-19
Maroun Khoury, Jimena Cuenca, Fernanda F. Cruz, Fernando E. Figueroa, Patricia R.M. Rocco, Daniel J. Weiss
European Respiratory Journal Jun 2020, 55 (6) 2000858; DOI: 10.1183/13993003.00858-2020
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  • Article
    • Abstract
    • Abstract
    • Introduction
    • Potential mechanisms of MSC actions in respiratory virus-induced lung injuries
    • Effects of respiratory viruses on MSC actions
    • Do MSCs express ACE2, the functional receptor of SARS-CoV-2?
    • MSCs in respiratory virus-related lung injury: pre-clinical evidence
    • Clinical investigations of MSC administration in patients with coronavirus or other respiratory virus-induced lung injury
    • Assessment of the ongoing cell-based clinical trials registered during the COVID-19 outbreak
    • Ethical issues for considering cell-based approaches for respiratory virus infections
    • Challenges and perspectives
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Online ISSN: 1399-3003

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