Abstract
Severe asthma is a high-burden disease. Real-world data on mepolizumab in patients with severe eosinophilic asthma is needed to assess whether the data from randomised controlled trials are applicable in a broader population.
The Australian Mepolizumab Registry (AMR) was established with an aim to assess the use, effectiveness and safety of mepolizumab for severe eosinophilic asthma in Australia.
Patients (n=309) with severe eosinophilic asthma (median age 60 years, 58% female) commenced mepolizumab. They had poor symptom control (median Asthma Control Questionnaire (ACQ)-5 score of 3.4), frequent exacerbations (median three courses of oral corticosteroids (OCS) in the previous 12 months), and 47% required daily OCS. Median baseline peripheral blood eosinophil level was 590 cells·µL−1. Comorbidities were common: allergic rhinitis 63%, gastro-oesophageal reflux disease 52%, obesity 46%, nasal polyps 34%.
Mepolizumab treatment reduced exacerbations requiring OCS compared with the previous year (annualised rate ratio 0.34 (95% CI 0.29–0.41); p<0.001) and hospitalisations (rate ratio 0.46 (95% CI 0.33–0.63); p<0.001). Treatment improved symptom control (median ACQ-5 reduced by 2.0 at 6 months), quality of life and lung function. Higher blood eosinophil levels (p=0.003) and later age of asthma onset (p=0.028) predicted a better ACQ-5 response to mepolizumab, whilst being male (p=0.031) or having body mass index ≥30 (p=0.043) predicted a lesser response. Super-responders (upper 25% of ACQ-5 responders, n=61, 24%) had a higher T2 disease burden and fewer comorbidities at baseline.
Mepolizumab therapy effectively reduces the significant and long-standing disease burden faced by patients with severe eosinophilic asthma in a real-world setting.
Abstract
In clinical practice, mepolizumab reduces the burden of severe eosinophilic asthma by reducing severe exacerbations and improving asthma control, quality of life and lung function. Super-responders have a T2 phenotype and few comorbidities. http://bit.ly/2UIio4x
Introduction
Severe asthma is a high burden disease [1–5], for which oral corticosteroids (OCS) are frequently required. Novel therapies are needed to reduce the burden from symptoms, exacerbations and OCS toxicity. Mepolizumab, a humanised IgG1/κ anti-interleukin (IL)-5 monoclonal antibody, targets the eosinophilic subtype of severe asthma, and is highly effective in clinical trials [6–11].
However, the eligibility for registration trials of monoclonal antibody therapy in severe asthma is highly restricted, such that up to 90% of patients with severe asthma in a real-world setting may not be eligible for an efficacy trial [12]. This limits the generalisability of randomised controlled trial (RCT) data in severe asthma, and raises questions regarding the real-world effectiveness of monoclonal antibody therapy in severe asthma.
Real-world observational data from clinical registries can be used to answer these questions [13, 14]. However, real-world data for mepolizumab is limited [15–21]. The Australian Mepolizumab Registry (AMR) was established to address this knowledge gap. Mepolizumab was listed as a reimbursable medication on the Australian Pharmaceutical Benefits Scheme (PBS) in January 2017. Clinical features and blood eosinophil level are used to select patients for subsidised mepolizumab, and clinical response guides continuation of therapy (table 1).
We hypothesised that mepolizumab would result in positive clinical outcomes in a real-world severe eosinophilic asthma population. The aims of the AMR are to describe severe eosinophilic asthma in Australia, the effectiveness of mepolizumab, and adverse drug-related effects in this population.
Methods
Study design
The AMR is an investigator-initiated national, multi-centre observational post-marketing surveillance registry of patients treated with mepolizumab for severe uncontrolled eosinophilic asthma and enrolled through centres of the Australasian Severe Asthma Network (ASAN) [5]. Centres (n=20) including hospital-based severe asthma, respiratory, immunology and allergy clinics and private respiratory practices, registered patients between January 2017 and April 2019. All sites received approval from the relevant Human Research Ethics Committee (supplementary material) and patients gave written informed consent prior to enrolment. The AMR was registered on the Australian New Zealand Clinical Trials Registry (ACTRN12618001497291).
Patients were assessed for eligibility (table 1) prior to initiation of mepolizumab and patients who commenced therapy were followed up prospectively. Baseline data were collected before commencement and patients received mepolizumab via their clinic or home service. Follow-up assessment occurred at 3 months post-commencement, and at 6 months and 12 months. Eligibility of patients to continue PBS-subsidised treatment was based on a reduction in ACQ-5 score of ≥0.5 from baseline or reduction in maintenance OCS dose of ≥25% without deterioration in ACQ-5 (table 1).
Patients
Patients ≥12 years (n=339) with severe eosinophilic asthma were enrolled and 309 patients commenced PBS-subsidised mepolizumab. Patient demographics, medical history, asthma diagnosis and history, exacerbation history, medication use and healthcare resource utilisation were recorded. Patients completed the five-item Asthma Control Questionnaire (ACQ)-5 [22], Asthma Control Test (ACT) [23] and standardised Asthma Quality of Life Questionnaire (AQLQ(S)) [24]. Spirometry (within month prior to starting mepolizumab), fraction of exhaled nitric oxide (FeNO), atopic status (skin prick test (SPT)/radioallergosorbent test/ImmunoCAP assay or previous omalizumab treatment), full blood count (including blood eosinophil level) and total serum immunoglobulin (Ig)E concentration (within 12 months prior) were recorded. Outcome data were collected at 3 months, 6 months and 12 months post-commencement of mepolizumab, and included frequency of severe exacerbations, change in ACQ-5, health-related quality of life (HRQoL)((AQLQ(S)), medication use, lung function and blood eosinophil levels. Patients who continued PBS-subsidised treatment after 6 months were identified as responders and further classified as “super-responders” (top 25% of ACQ-5 responses from baseline or well-controlled asthma symptoms (ACQ-5<1.0)) [25].
Database management and quality control
Data were collected and managed using REDCap electronic data capture tools hosted at Hunter Medical Research Institute, Newcastle, Australia [26]. The AMR REDCap template was adapted from data collection platforms of the ASAN Severe Asthma Web-based Database [5] and the Alfred Difficult Asthma Service Melbourne, Australia [27].
Statistical analysis
Statistical analyses were performed using Stata14.2 (StataCorp, College Station, TX, USA); results are reported as mean±sd for normally distributed data and median (interquartile range) for non-normally distributed data. Comparisons were performed using Chi-squared or Fisher's exact test for categorical data and Student's t-test or Wilcoxon rank-sum test for continuous data. The annualised rate of exacerbations for the study period was analysed using a negative binomial generalised estimating equation incorporating repeated measures across patients, producing population-averaged estimates. The within-group correlation structure was specified as exchangeable and a logarithm of time was included as an offset variable. From this, the rate ratio comparing exacerbations prior to and post-commencement of mepolizumab treatment was calculated, as well as the estimated rate per year and associated 95% confidence intervals. Baseline predictors of ACQ-5 response were evaluated using multiple linear regression. Variables for the multivariate models were chosen if the p-value was <0.2 in the linear model (supplementary material). Results were considered significant when p<0.05.
Results
Patients (n=339) were enrolled in AMR and n=309 confirmed eligible patients commenced PBS-subsidised mepolizumab (figure 1). After 6-months of treatment, there were 260 (86%) out of 302 mepolizumab responders (according to PBS-continuation criteria, table 1), after excluding patients awaiting assessment (n=7). Of the responders, 197 (93%) out of 211 were still responders at the 12-month assessment, after excluding patients awaiting assessment (n=49).
Baseline characteristics
Patients had a median age of 60 years and 58% were female (table 2). Patients had poor symptom control, median (IQR) ACQ-5 score of 3.4 (3.0–4.2), and 28% had been hospitalised for an asthma exacerbation in the previous year. Comorbidities were common (supplementary table S1). At baseline, 47% of patients were taking prescribed maintenance OCS at a median (IQR) daily dose of 10 (5–12.5) mg·day−1 prednisolone equivalent. Patients were using median (IQR) 4 (3–5) respiratory medications for their severe asthma therapy. In addition to inhaled corticosteroid (ICS) and long-acting β-agonist (LABA), long-acting muscarinic antagonist (LAMA) was used by 53%, montelukast by 12%, theophylline by 6%, antifungal azoles by 3%, methotrexate by 4% and low-dose macrolides by 9%. 16% of patients had received prior treatment with omalizumab, 3% had received prior anti-IL5 monoclonal antibody therapy, and 4% had been treated with bronchial thermoplasty.
Response to mepolizumab
Patients received mepolizumab treatment for 352 (223–377) days. Significant and sustained biological and clinical responses to mepolizumab were reported over the 12-month period (figure 2). Blood eosinophil levels reduced from median (IQR) 590 (400–830) cells·µL−1 at baseline to 100 (40–100) cells·µL−1 (p<0.001) at the 3-month assessment, and remained at this level at the 12-month assessment (figure 2a).
Patients reported a significant improvement in symptom control (ACQ-5 reduction) (ACQ-5 median (IQR) 3.4 (3.0–4.2) at baseline versus 1.6 (0.8–2.6) at the 3-month assessment, p<0.001). The improvement in ACQ-5 was maintained at subsequent assessments (figure 2b). Patients reported significant and increasing improvements in HRQoL (figure 2c) and lung function improved (figure 2d).
There was a significant reduction in the annualised rates of severe asthma exacerbations in comparison to the 12 months prior to treatment (figure 3) (n=306). The rate of exacerbation (per person-year) requiring OCS was reduced by 66% (95% CI 59–71), p<0.001, requiring hospitalisation was reduced by 54% (95% CI 37–67), p<0.001, and emergency room visitation by 56% (95% CI 25–74), p=0.003. The reduction in the rate of exacerbations was greatest for exacerbations resulting in unscheduled doctor visits, with a reduction of 83% (95% CI 72–89), p<0.001.
Following mepolizumab commencement, the proportion of patients requiring maintenance OCS was reduced from 47% at baseline to 30% at the 6-month assessment (p<0.001), with the daily dose reduced from median (IQR) 10 (5.0–12.5) to 7.5 (5.0–10.0) mg·day−1 prednisolone equivalent (p=0.001) in patients requiring OCS.
Cessation of mepolizumab
Mepolizumab was ceased by 45 (14.6%) out of 309 patients during the 12-month period (figure 1 and table 3). The most common reasons for cessation were failed ACQ response and clinician decision.
Safety of mepolizumab
Mepolizumab administration data were available for 2374 mepolizumab administration events (table 4). An adverse drug reaction was reported for 18.8% of patients. The most-commonly reported reactions were headache (9.9% of patients). No anaphylaxis events were reported. Mepolizumab treatment was ceased by six patients due to adverse drug reactions.
Of 25 recorded severe adverse effects (SAEs) (supplementary table S2), two were fatal (cause of death recorded: acute myocardial infarction and ischaemic heart disease). None of the SAEs had suspected causality to mepolizumab. Treatment was temporarily adjusted or interrupted following four SAEs and permanently discontinued following one (metastatic brain lesion).
Response to mepolizumab by baseline blood eosinophil level
Patients with baseline blood eosinophil levels >600 cells·µL−1 (Eo-high patients, 42%), reported a greater improvement in ACQ-5 score relative to baseline at the 3-month assessment compared to patients with blood eosinophils ≤600 cells·µL−1 (Eo-low) (mean±sd ACQ-5 improvement of −2.0±1.3 versus −1.6±1.2; p=0.013). The magnitude of response remained significantly greater in the Eo-high patients at 6-months (p=0.003) and 12-months (p=0.047) (supplementary table S3).
Eo-high patients reported a significantly greater improvement in AQLQ(S) score at 3-months (mean±sdAQLQ(S) improvement of 1.4±1.2 versus 1.0±1.1; p=0.019) and 6-months (mean±sdAQLQ(S) 1.6±1.3 versus 1.1±1.1; p=0.026). There was greater improvement in lung function in Eo-high patients at 12-months post-mepolizumab commencement (median (IQR) forced expiratory volume in 1 s (FEV1) % predicted improvement of 8.0 (−0.9–16.3) versus 3.2 (−1.7–8.8)%; p=0.032) compared with patients with blood eosinophils ≤600 cells·µL−1.
Mepolizumab response predictors
Patients with late onset asthma (onset ≥40 years of age, n=86, 31%) were predominantly male with greater smoking exposure. They had a median (IQR) asthma duration of 12.3 (4.9–18.8) years compared with 37.9 (24.3–51.9) years, p<0.001, in early onset asthma (<40 years). Clinical responses to mepolizumab were similar in both the early and late age of onset categories (supplementary tables S4 and S5), and in non-atopic and atopic patients with eosinophilic asthma (supplementary tables S4 and S6).
In multivariate regression analysis models, male sex (p=0.031) and body mass index (BMI) ≥30 kg·m−2 (p=0.043) predicted reduced ACQ-5 response, whilst higher baseline blood eosinophil levels (p=0.003) and later age of asthma onset (p=0.028) predicted greater improvement in ACQ-5 response. Age did not significantly predict ACQ-5 response in the multivariate model.
Patients identified as responders had similar baseline ACQ-5 scores, higher blood eosinophil levels and were less likely to be using maintenance OCS, compared to treatment-failures (supplementary table S7 and S8).
Mepolizumab super-responders
Mepolizumab treatment resulted in a median (IQR) reduction in ACQ-5 score of −2.0 (−1.4−3.0) in responders, with 79 (31%) patients achieving well-controlled symptoms (ACQ-5 <1.0). Clinicians recognise some patients who have an exceptionally good response, termed “super-responders”. Super-responders were defined as those in the top 25% of ACQ responses (61 out of 252 PBS-defined responders), or those who achieved well-controlled asthma after 6-months of treatment (79 out of 252) (supplementary table S8). The ACQ super-responders had a median (IQR) ACQ-5 score reduction of −3.4 (−3.2−4.0) units, compared with −1.0 (−0.6−1.2) in the bottom 25% of responders (figure 4a). Patients who achieved well-controlled asthma had a median ACQ-5 reduction of −3.0 (−2.4−3.6), compared with −1.4 (−1.0−2.0) in those whose symptoms remained uncontrolled (ACQ-5 >1.5) at 6-months.
ACQ super-responders were predominantly female (67% versus 43%; p=0.005), had a lower baseline BMI (median 27.8 (23.8–31.8) versus 31.0 (26.4–35.7) kg·m−2; p=0.006), tended to never have smoked (70% versus 56%; p=0.094) and had a shorter duration of asthma (median 23.6 (10.7–37.9) versus 34.1 (17.9–43.6) years; p=0.037). They had higher baseline blood eosinophils (median 700 (430–1010) versus 535 (400–805) cells·µL−1; p=0.043) and FeNO (41 (21–63) versus 23 (15–41) ppb; p=0.026) (figure 4b) and a higher baseline ACQ-5 (median 4.2 (3.6–4.8) versus 3.0 (2.6–3.6); p<0.001). They were less likely to be taking maintenance OCS at baseline (36% versus 56%; p=0.025). ACQ super-responders were more likely to have a diagnosis of nasal polyps (48% versus 30%; p=0.035), whilst gastro-oesophageal reflux disease (GORD) (35% versus 52%; p=0.046), obstructive sleep apnoea (OSA) (16% versus 36%; p=0.010), psychiatric disorders (21% versus 46%; p=0.003) and cardiovascular disease (CVD) (12% versus 34%; p=0.004) were less common (figure 4c).
Patients who achieved well-controlled symptoms after 6-months of treatment (ACQ-5 <1.0, n=79) were compared to those with ACQ-5 >1.5 (uncontrolled, n=111). Patients who achieved control were more likely to be never smokers (78% versus 55%; p=0.002) and had a lower baseline BMI (median 27.5 (23.8–30.5) versus 31.8 (27.1–36.6) kg·m-2; p<0.001). They had significantly less symptoms at baseline; (median ACQ-5 score 3.4 (2.8–4.0) versus 3.6 (3.2–4.4); p<0.001), and had required less OCS treatment for exacerbations in the previous year (3 (2–5) versus 4 (2–7); p=0.046). They had higher FeNO levels (median 50.8 (29.0–94.0) versus 23.0 (13.0–40.5); p<0.001), and were taking fewer respiratory medications at baseline (median 3 (3–5) versus 4 (3–5); p=0.002). Asthma triggers differed, with exercise and reflux noted as significantly less common in patients who achieved control. Comorbidities were less prevalent in these patients; GORD (32% versus 63%, p<0.001), OSA (9% versus 30%, p<0.001), vocal cord dysfunction (3% versus 13%, p=0.015), psychiatric disorders (17% versus 41%, p<0.001), CVD (12% versus 31%, p=0.002), diabetes (7% versus 17%, p=0.031).
Comparison of AMR patients with regulatory trial participants
Compared to participants of the MENSA (Efficacy and Safety Study of Mepolizumab Adjunctive Therapy in Subjects With Severe Uncontrolled Refractory Asthma) and MUSCA (Efficacy and Safety Study of Mepolizumab Adjunctive Therapy in Participants With Severe Eosinophilic Asthma on Markers of Asthma Control) RCTs (supplementary table S9), AMR patients were older, with a longer duration of asthma, more maintenance OCS use, higher baseline ACQ-5 score and higher blood eosinophil levels. At the 6-month assessment, AMR patients reported a greater improvement in asthma control (ACQ-5) compared to MENSA/MUSCA participants.
Discussion
Mepolizumab is highly effective in treating severe refractory eosinophilic asthma in a real-world setting, where the treatment effect was as great, if not greater, than that reported in RCTs, despite the population having more severe asthma, being older and having a greater comorbidity profile. The beneficial effects observed included fewer severe asthma exacerbations, improved asthma symptom control, improved HRQoL and improved lung function. The drug was well tolerated, and the PBS selection criteria identified a group with a high individual response rate. Higher baseline blood eosinophils predicted a better response, and the drug was observed to be similarly effective in both atopic and non-atopic patients, as well as in those with early and late-onset asthma. We were able to identify a group of super-responders, who were predominantly women with high levels of T2 disease expression and few confounding comorbidities. These real-world data complement and extend the findings from highly controlled RCTs and provide further insight into response prediction when using mepolizumab in a clinical practice setting.
Predicting which patients will have the best response to mepolizumab (super-responders) is important, particularly as an individual patient with severe asthma may be eligible for several different add-on treatment options. Mepolizumab super-responders had shorter duration of asthma, less severe disease and had substantial treatment response. As such, appropriate patient phenotyping and targeting with mepolizumab therapy at an early time-point during the progression of disease; for example, as soon as asthma is identified as severe, may be advantageous in this context. Further characterisation of super-responders based on combined response criteria, including exacerbations and maintenance OCS use, will be beneficial.
The overall response rate to mepolizumab (based on PBS criteria for continuation) in the AMR was high at 86%, and likely attributable to the effective phenotyping and subsequent targeted treatment according to the PBS initiation criteria. In agreement with the RCT findings, we also report enhanced clinical responses with increasing baseline blood eosinophils [28, 29]. The median blood eosinophil level in AMR patients was 590 cells·µL−1, which was significantly greater than that of the MENSA/MUSCA participants, and is a likely reason for the enhanced magnitude of clinical response observed in AMR patients, compared to the RCT participants, where baseline blood eosinophils levels of ≥150 cells·µL−1 were acceptable for eligibility [9, 11]. AMR patients required blood eosinophil levels ≥300 cells·µL−1 during the 12 months prior to initiation (according to PBS-initiation criteria). However, the subsequent commencement of maintenance OCS in a proportion of these patients would be expected to result in a lower “true baseline” blood eosinophil level. As such, the reported relationship between baseline blood eosinophil level and the magnitude of response in this study is likely to be under-estimated in these patients. Future real-world evaluation of response in patients with blood eosinophil levels as low as 150 cells·µL−1 will be informative, particularly when considering mepolizumab treatment for patients who have required ongoing maintenance OCS treatment and may not meet a higher blood eosinophil cut-off level.
In addition to elevated baseline blood eosinophil levels, AMR patients also had substantial baseline ACQ-5 scores (with an ACQ-5 score ≥2.0 required for eligibility for initiation of mepolizumab therapy), which were higher than baseline scores reported in the RCTs, where there were no symptom score criteria for trial eligibility [9, 11]. As such, the greater magnitude of ACQ-5 response observed in AMR patients relative to the RCTs is also likely attributable to the patients being more symptomatic at baseline.
Patients with late onset severe asthma are phenotypically distinct to those with earlier onset asthma, are generally non-atopic and often more severe [30, 31]. Eosinophilia is present in both phenotypes, indicating that anti-IL5 targeted treatments may be of benefit regardless of age of onset. In order to evaluate response to mepolizumab treatment in severe eosinophilic asthma relative to age of onset, we chose a cut-off of ≥40 years to identify late-onset asthma as described by others [32]. Consistent with other studies, early onset patients were predominantly atopic and had more allergic diseases, whilst the late onset group had more environmental exposures [33]. More than half of the late onset group were male, aligning with the recognised and difficult-to-treat adult-onset eosinophilic asthma phenotype [34, 35]. Despite the differing drivers of eosinophilic inflammation in these phenotypes, the baseline blood eosinophil levels were equivalent in AMR patients, regardless of age of onset, and we report similar clinical responses in each group. This is in agreement with a post hoc analysis of the COLUMBA study (Open-label Long Term Extension Safety Study of Mepolizumab in Asthmatic Subjects) [36]. Thus, targeted mepolizumab treatment in patients with severe eosinophilic asthma is likely to be of benefit regardless of the patient's age of onset phenotype.
Real-world observational studies have inherent limitations. As an observational post-marketing surveillance registry, patients in the AMR were not a randomised population, and the treatment trial was not controlled, and was therefore subject to bias and confounding factors. Response to treatment was assessed using the ACQ-5, a patient-reported symptom questionnaire, which may have led to response bias. However, it is a validated questionnaire for assessing treatment response and is used routinely in clinical practice [22]. The improvements in other outcomes such as reduction of severe exacerbations requiring hospitalisation/OCS treatment and improvements in lung function indicate that response bias was unlikely as these are objective measures of response. Another limitation identified in AMR was in the variability of comorbidity reporting, as this was a combination of physician diagnoses and patient reported comorbidity. However, the prevalence of comorbidities observed in the AMR were reflective of the rates expected in severe eosinophilic asthma. Nevertheless, despite their inherent limitations, real-world studies are gaining considerable acceptance when considering the ways in which these data complements and extends the findings of more tightly controlled studies in restricted populations.
Conclusion
The AMR reports that patients with severe uncontrolled eosinophilic asthma experience substantial disease burden and impact. We show that mepolizumab effectively reduces this burden, as demonstrated by a reduction in severe exacerbations and improvements in symptom control, health status and lung function. These findings complement the findings of RCTs and, in fact, suggest that when targeted appropriately in real-world clinical practice, patients can display superior clinical responses to mepolizumab. Further exploration of predictive factors and characterisation of mepolizumab responders in the real-world setting may be informative for future clinical management decisions.
Supplementary material
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Acknowledgements
We thank Siva P. Sivakumaran (Gold Coast University Hospital, Southport, Australia), Zinta Harrington (Liverpool Hospital, Liverpool, Australia) and Nicholas Harkness (Royal Hobart Hospital, Hobart, Australia) for contributing to the AMR.
Footnotes
This article has supplementary material available from erj.ersjournals.com
Author contributions: All authors were involved in data interpretation and critical review of the manuscript. P.G. Gibson, E.S. Harvey, D. Langton, C. Katelaris, C.S. Farah, A. Gillman, J. Harrington, M. Hew, V. Kritikos, N. Radhakrishna, P. Bardin, M. Peters, P.N. Reynolds and J.W. Upham contributed to development of study concept and design. S. Stevens performed data analysis. E.S. Harvey, P.G. Gibson, D. Langton, C. Katelaris, C.S. Farah, A. Gillman, J. Harrington, M. Hew, V. Kritikos and N. Radhakrishna drafted the manuscript.
Conflict of interest: E.S. Harvey reports grants from GlaxoSmithKline that were paid to her employer, during the conduct of the study.
Conflict of interest: D. Langton has received fees from GlaxoSmithKline for participation in severe asthma advisory boards.
Conflict of interest: C. Katelaris reports grants from GlaxoSmithKline, during the conduct of the study; grants and personal fees for advisory board work and lectures from Sanofi, Novartis and CSL, personal fees from Seqirus and Takeda, outside the submitted work.
Conflict of interest: S. Stevens has nothing to disclose.
Conflict of interest: C.S. Farah reports personal fees from AstraZeneca, Boehringer Ingelheim, GlaxoSmithKline and Sanofi Genzyme, outside the submitted work.
Conflict of interest: A. Gillman reports personal fees for advisory board work and education from GlaxoSmithKline, outside the submitted work.
Conflict of interest: J. Harrington reports personal fees for education and advisory board work from AstraZeneca and GlaxoSmithKline, personal fees for education from Novartis, outside the submitted work.
Conflict of interest: M. Hew reports grants and personal fees from AstraZeneca, GlaxoSmithKline and Novartis, personal fees from Sanofi, Teva and Seqirus, outside the submitted work; all paid to his institutional employer Alfred Health.
Conflict of interest: V. Kritikos has nothing to disclose.
Conflict of interest: N. Radhakrishna reports grants from Sanofi, outside the submitted work.
Conflict of interest: P. Bardin reports per patient trial participation fees from Monash Lung and Sleep, during the conduct of the study; personal fees for advisory board work from Philip Bardin, outside the submitted work.
Conflict of interest: M. Peters reports personal fees for advisory board work from Sanofi Genzyme, Novartis Pharmaceuticals and AstraZeneca, outside the submitted work.
Conflict of interest: P.N. Reynolds reports grants from GlaxoSmithKline and AstraZeneca, during the conduct of the study.
Conflict of interest: J.W. Upham reports grants and personal fees from AstraZeneca and GlaxoSmithKline, personal fees from Novartis and Boehringer Ingelheim, outside the submitted work.
Conflict of interest: M. Baraket has nothing to disclose.
Conflict of interest: S. Bowler reports personal fees for advisory board work from GlaxoSmithKline, outside the submitted work.
Conflict of interest: J. Bowden reports personal fees for advisory board work from GlaxoSmithKline, AstraZeneca and Novartis, outside the submitted work.
Conflict of interest: J. Chien reports personal fees from GlaxoSmithKline, outside the submitted work.
Conflict of interest: L.P. Chung has nothing to disclose.
Conflict of interest: C. Grainge reports personal fees from Boehringer Ingelheim, Roche Pharmaceuticals and GlaxoSmithKline, outside the submitted work.
Conflict of interest: C. Jenkins reports personal fees for advisory board work, conducting meetings and developing educational content, and non-financial support from AstraZeneca, personal fees for advisory board work from Boehringer Ingleheim, grants and personal fees for advisory board work from GlaxoSmithKline, personal fees for advisory board work, facilitating symposia and developing educational content from Novartis, outside the submitted work.
Conflict of interest: G.P. Katsoulotos has nothing to disclose.
Conflict of interest: J. Lee reports personal fees for lectures from Boehringer Ingelheim and AstraZeneca, personal fees for consultancy from GlaxoSmithKline, outside the submitted work.
Conflict of interest: V.M. McDonald reports grants and personal fees from GlaxoSmithKline, AstraZeneca and Menarini, outside the submitted work.
Conflict of interest: H.K. Reddel reports grants from GlaxoSmithKline, during the conduct of the study; grants and personal fees for data monitoring committee work, advisory board work, providing independent medical education and consultancy from AstraZeneca, grants, personal fees for data monitoring committee work, advisory board work, providing independent medical education and consultancy and non-financial support (study medication) from GlaxoSmithKline, personal fees for data monitoring committee work from Merck, grants and personal fees for data monitoring committee work, advisory board work and providing independent medical education from Novartis, personal fees for providing independent medical education from Teva and Mundipharma, personal fees for advisory board work and providing independent medical education from Boehringer Ingelheim, personal fees for advisory board work from Sanofi Genzyme, outside the submitted work.
Conflict of interest: J. Rimmer has nothing to disclose.
Conflict of interest: P.A.B. Wark has nothing to disclose.
Conflict of interest: P.G. Gibson reports grants from GlaxoSmithKline, during the conduct of the study; personal fees for lectures from AstraZeneca, GlaxoSmithKline and Novartis, grants from AstraZeneca and GlaxoSmithKline, outside the submitted work.
Support statement: The Australian Mepolizumab Registry is an investigator-initiated and managed study funded through the GlaxoSmithKline Investigator-Sponsored Studies program. Funding information for this article has been deposited with the Crossref Funder Registry.
- Received December 17, 2019.
- Accepted February 7, 2020.
- Copyright ©ERS 2020