Subjects n | 3 | 27 | | 5 | 25 | |
Male | 3 (100) | 17 (63) | 0.532 | 5 (100) | 15 (60) | 0.140 |
Age years¶ | 73 (69–77) | 67 (45–82) | 0.306 | 73 (69–77) | 67 (45–82) | 0.167 |
Ex-smokers | 3 (100) | 18 (67) | 0.532 | 5 (100) | 16 (64) | 0.286 |
Smoking history¶ pack-years | 32 (32–32) | 47 (19–54) | 0.745 | 46 (32–53) | 47 (18–54) | 0.976 |
FEV1 % predicted | 23±2 | 51±25 | 0.130 | 28±7 | 53±26 | 0.071 |
Total VAS mm | 271.5±53.0 | 128.7±98.1 | 0.055 | 234.0±66.7 | 123.0±99.1 | 0.042* |
VAS cough | 67.5±6.4 | 34.5±27.9 | 0.107 | 58.8±14.6 | 33.3±28.0 | 0.089 |
VAS breathlessness | 60.5±26.2 | 33.7±27.9 | 0.200 | 59.8±17.6 | 31.5±27.8 | 0.062 |
VAS sputum production | 75.5±2.1 | 31.4±29.4 | 0.047* | 64.0±15.9 | 29.6±29.8 | 0.035* |
VAS sputum discolouration | 68.0±18.4 | 29.1±28.5 | 0.071 | 51.5±25.4 | 28.6±29.3 | 0.154 |
CAT units | 29.0±5.7 | 19.6±9.4 | 0.185 | 26.0±6.6 | 19.6±9.7 | 0.282 |
Blood neutrophils# ×109 per L | 5.24 (4.21–15.98) | 4.97 (3.91–6.30) | 0.467 | 6.29 (4.73–11.39) | 4.93 (3.88–5.82) | 0.099 |
Blood eosinophils# ×109 per L | 0.16 (0.02–0.18) | 0.18 (0.15–0.27) | 0.307 | 0.18 (0.09–0.39) | 0.18 (0.14–0.21) | 0.703 |
Sputum total cell count# ×106 per g | 32.58 (8.02–40.45) | 2.55 (0.90–5.50) | 0.005* | 22.18 (4.24–36.52) | 2.55 (1.25–4.79) | 0.056 |
Sputum neutrophil count# ×106 per g | 11.84 (3.95–14.00) | 0.49 (0.23–1.32) | 0.002* | 9.06 (2.02–12.92) | 0.49 (0.24–1.25) | 0.043* |
Sputum neutrophil % | 91±10 | 71±16 | 0.036* | 86±10 | 70±16 | 0.039* |
Sputum eosinophil# % | 0.20 (0.00–1.00) | 1.00 (0.20–5.00) | 0.231 | 1.00 (0.10–10.00) | 1.00 (0.20–3.25) | 0.837 |
Colony forming unit# ×106 per mL | 21.33 (21.00–21.65) | 0.38 (0.21–0.67) | 0.008* | 21.33 (21.00–21.65) | 0.38 (0.21–0.67) | 0.008* |