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Inspiratory vocal cord closure in COPD

Paul Leong, Laurence E. Ruane, Debra Phyland, Joo Koh, Martin I. MacDonald, Malcom Baxter, Kenneth K. Lau, Kais Hamza, Philip G. Bardin
European Respiratory Journal 2020 55: 1901466; DOI: 10.1183/13993003.01466-2019
Paul Leong
1Monash Lung and Sleep, Monash Health and Monash University, Clayton, Australia
2Hudson Institute, Clayton, Australia
6Equal contribution
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  • For correspondence: paul.leong@monash.edu
Laurence E. Ruane
1Monash Lung and Sleep, Monash Health and Monash University, Clayton, Australia
2Hudson Institute, Clayton, Australia
6Equal contribution
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Debra Phyland
3Dept of Otolaryngology, Head and Neck Surgery, Monash Health, Clayton, Australia
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Joo Koh
3Dept of Otolaryngology, Head and Neck Surgery, Monash Health, Clayton, Australia
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Martin I. MacDonald
1Monash Lung and Sleep, Monash Health and Monash University, Clayton, Australia
2Hudson Institute, Clayton, Australia
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Malcom Baxter
3Dept of Otolaryngology, Head and Neck Surgery, Monash Health, Clayton, Australia
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Kenneth K. Lau
4Diagnostic Imaging, Monash University and Monash Health, Clayton, Australia
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Kais Hamza
5Dept of Mathematical Sciences, Monash University, Clayton, Australia
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Philip G. Bardin
1Monash Lung and Sleep, Monash Health and Monash University, Clayton, Australia
2Hudson Institute, Clayton, Australia
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Tables

  • Supplementary Materials
  • TABLE 1

    Demographic characteristics of subjects included in studies

    Healthy individuals (n=40)Stable COPD (n=76)Acute exacerbations of COPD (n=61)p-value for group comparison
    Age years61.6±12.069.3±10.271.5±11.10.70
    Sex (females/males)25/1533/4323/380.35
    Body mass index (kg·m−2)29.5±5.728.3±7.424.9±4.90.19
    Smoking pack-years8.6±13.641.1±25.659.1±51.90.027
    Lung function
     FEV1 post-bronchodilator % pred100.9±16.755.6±23.348.2±19.80.062
     FEV1/FVC %76.1±7.646.2±13.348.8±15.00.31
     Bronchodilator response %3.5±3.79.0±9.46.2±7.90.21
     TLCO % pred89.6±13.658.9±21.749.9±21.30.032
    Inhaled treatment(s)
     Inhaled corticosteroidsNone14 (18.4%)43 (70%)<0.0001
     Long-acting β-agonistNone59 (77.6%)43 (70%)0.43
     Long-acting muscarinic antagonistNone58 (76.3%)38 (62%)0.09
    Inspiratory vocal cord closureNone21 (27.6%)19 (31.1%)0.71
    Expiratory vocal cord closureNone22 (28.9%)17 (27.9%)1.0

    Values are presented as mean±sd or n (%), unless otherwise stated. p values from ANOVA, or Fisher's exact test as appropriate. FEV1: forced expiratory volume in 1 s; FVC: forced vital capacity; TLCO: diffusing/transfer capacity for carbon monoxide.

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    Inspiratory vocal cord closure in COPD
    Paul Leong, Laurence E. Ruane, Debra Phyland, Joo Koh, Martin I. MacDonald, Malcom Baxter, Kenneth K. Lau, Kais Hamza, Philip G. Bardin
    European Respiratory Journal May 2020, 55 (5) 1901466; DOI: 10.1183/13993003.01466-2019

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    Inspiratory vocal cord closure in COPD
    Paul Leong, Laurence E. Ruane, Debra Phyland, Joo Koh, Martin I. MacDonald, Malcom Baxter, Kenneth K. Lau, Kais Hamza, Philip G. Bardin
    European Respiratory Journal May 2020, 55 (5) 1901466; DOI: 10.1183/13993003.01466-2019
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