Table of Contents

Original Articles

• Pleural disease

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    Intercostal vessel screening prior to pleural interventions by the respiratory physician: a prospective study of real world practice

    Eihab O. Bedawi, Ambika Talwar, Maged Hassan, David J. McCracken, Rachelle Asciak, Rachel M. Mercer, Nikolaos I. Kanellakis, Fergus V. Gleeson, Rob J. Hallifax, John M. Wrightson, Najib M. Rahman

    European Respiratory Journal 55 (4) 1902245; DOI: 10.1183/13993003.02245-2019 Published 30 April 2020

• Asthma

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    Crucial role for lung iron level and regulation in the pathogenesis and severity of asthma

    Md. Khadem Ali, Richard Y. Kim, Alexandra C. Brown, Jemma R. Mayall, Rafia Karim, James W. Pinkerton, Gang Liu, Kristy L. Martin, Malcolm R. Starkey, Amber L. Pillar, Chantal Donovan, Prabuddha S. Pathinayake, Olivia R. Carroll, Debbie Trinder, Hock L. Tay, Yusef E. Badi, Nazanin Z. Kermani, Yi-Ke Guo, Ritambhara Aryal, Sharon Mumby, Stelios Pavlidis, Ian M. Adcock, Jessica Weaver, Dikaia Xenaki, Brian G. Oliver, Elizabeth G. Holliday, Paul S. Foster, Peter A. Wark, Daniel M. Johnstone, Elizabeth A. Milward, Philip M. Hansbro, Jay C. Horvat

    European Respiratory Journal 55 (4) 1901340; DOI: 10.1183/13993003.01340-2019 Published 23 April 2020
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    Patient preferences for symptom-driven or regular preventer treatment in mild to moderate asthma: findings from the PRACTICAL study, a randomised clinical trial

    Christina Baggott, Helen K. Reddel, Jo Hardy, Jenny Sparks, Mark Holliday, Andrew Corin, Barney Montgomery, Jim Reid, Davitt Sheahan, Robert J. Hancox, Mark Weatherall, Richard Beasley, James Fingleton on behalf of the PRACTICAL study team

    European Respiratory Journal 55 (4) 1902073; DOI: 10.1183/13993003.02073-2019 Published 16 April 2020
  • Open Access

    Overuse of short-acting β₂-agonists in asthma is associated with increased risk of exacerbation and mortality: a nationwide cohort study of the global SABINA programme

    Bright I. Nwaru, Magnus Ekström, Pål Hasvold, Fredrik Wiklund, Gunilla Telg, Christer Janson

    European Respiratory Journal 55 (4) 1901872; DOI: 10.1183/13993003.01872-2019 Published 16 April 2020

• Asthma and paediatrics

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    Early-life antibiotic use and risk of asthma and eczema: results of a discordant twin study

    Elise M.A. Slob, Bronwyn K. Brew, Susanne J.H. Vijverberg, Chantal J.A.R. Kats, Cristina Longo, Mariëlle W. Pijnenburg, Toos C.E.M. van Beijsterveldt, Conor V. Dolan, Meike Bartels, Patrick Magnusson, Paul Lichtenstein, Tong Gong, Gerard H. Koppelman, Catarina Almqvist, Dorret I. Boomsma, Anke H. Maitland-van der Zee

    European Respiratory Journal 55 (4) 1902021; DOI: 10.1183/13993003.02021-2019 Published 23 April 2020

• Paediatrics

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    Normative data for multiple breath washout outcomes in school-aged Caucasian children

    Pinelopi Anagnostopoulou, Philipp Latzin, Renee Jensen, Mirjam Stahl, Alana Harper, Sophie Yammine, Jakob Usemann, Rachel E. Foong, Ben Spycher, Graham L. Hall, Florian Singer, Sanja Stanojevic, Marcus A. Mall, Felix Ratjen, Kathryn A. Ramsey

    European Respiratory Journal 55 (4) 1901302; DOI: 10.1183/13993003.01302-2019 Published 3 April 2020

• Paediatrics and orphan diseases

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    International consensus guideline for reporting transmission electron microscopy results in the diagnosis of primary ciliary dyskinesia (BEAT PCD TEM Criteria)

    Amelia Shoemark, Mieke Boon, Christoph Brochhausen, Zuzanna Bukowy-Bieryllo, Maria M. De Santi, Patricia Goggin, Paul Griffin, Richard G. Hegele, Robert A. Hirst, Margaret W. Leigh, Alison Lupton, Karen MacKenney, Heymut Omran, Jean-Claude Pache, Andreia Pinto, Finn P. Reinholt, Josep Schroeder, Panayotis Yiallouros, Estelle Escudier representing the BEAT-PCD Network Guideline Development Group

    European Respiratory Journal 55 (4) 1900725; DOI: 10.1183/13993003.00725-2019 Published 16 April 2020

• Sleep

  • Open Access

    Severe desaturations increase psychomotor vigilance task-based median reaction time and number of lapses in obstructive sleep apnoea patients

    Samu Kainulainen, Brett Duce, Henri Korkalainen, Arie Oksenberg, Akseli Leino, Erna S. Arnardottir, Antti Kulkas, Sami Myllymaa, Juha Töyräs, Timo Leppänen

    European Respiratory Journal 55 (4) 1901849; DOI: 10.1183/13993003.01849-2019 Published 9 April 2020

• Rare lung diseases

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    Potential therapeutic targets for lung repair during human ex vivo lung perfusion

    Aaron Wong, Ricardo Zamel, Jonathan Yeung, Gary D. Bader, Claudia C. Dos Santos, Xiaohui Bai, Yubo Wang, Shaf Keshavjee, Mingyao Liu

    European Respiratory Journal 55 (4) 1902222; DOI: 10.1183/13993003.02222-2019 Published 9 April 2020

• Interstitial lung disease

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    Probable usual interstitial pneumonia pattern on chest CT: is it sufficient for a diagnosis of idiopathic pulmonary fibrosis?

    Jun Fukihara, Yasuhiro Kondoh, Kevin K. Brown, Tomoki Kimura, Kensuke Kataoka, Toshiaki Matsuda, Yasuhiko Yamano, Atsushi Suzuki, Taiki Furukawa, Hiromitsu Sumikawa, Osamu Takahashi, Takeshi Johkoh, Tomonori Tanaka, Junya Fukuoka, Naozumi Hashimoto, Yoshinori Hasegawa

    European Respiratory Journal 55 (4) 1802465; DOI: 10.1183/13993003.02465-2018 Published 9 April 2020
  • Open Access

    Bacterial burden in the lower airways predicts disease progression in idiopathic pulmonary fibrosis and is independent of radiological disease extent

    Rachele Invernizzi, Joseph Barnett, Bhavin Rawal, Arjun Nair, Poonam Ghai, Shaun Kingston, Felix Chua, Zhe Wu, Athol U. Wells, Elizabeth R. Renzoni, Andrew G. Nicholson, Alexandra Rice, Clare M. Lloyd, Adam J. Byrne, Toby M. Maher, Anand Devaraj, Philip L. Molyneaux

    European Respiratory Journal 55 (4) 1901519; DOI: 10.1183/13993003.01519-2019 Published 3 April 2020
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    Acute exacerbation of idiopathic pulmonary fibrosis: international survey and call for harmonisation

    Michael Kreuter, Markus Polke, Simon L.F. Walsh, Johannes Krisam, Harold R. Collard, Nazia Chaudhuri, Sergey Avdeev, Jürgen Behr, Gregory Calligaro, Tamera Corte, Kevin Flaherty, Manuela Funke-Chambour, Martin Kolb, Yasuhiro Kondoh, Toby M. Maher, Maria Molina Molina, Antonio Morais, Catharina C. Moor, Julie Morisset, Carlos Pereira, Silvia Quadrelli, Moises Selman, Argyrios Tzouvelekis, Claudia Valenzuela, Carlo Vancheri, Vanesa Vicens-Zygmunt, Julia Wälscher, Wim Wuyts, Marlies Wijsenbeek, Vincent Cottin, Elisabeth Bendstrup

    European Respiratory Journal 55 (4) 1901760; DOI: 10.1183/13993003.01760-2019 Published 3 April 2020

• Cystic fibrosis

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    Early markers of cystic fibrosis structural lung disease: follow-up of the ACFBAL cohort

    Naomi E. Wijker, Suzanna Vidmar, Keith Grimwood, Peter D. Sly, Catherine A. Byrnes, John B. Carlin, Peter J. Cooper, Colin F. Robertson, R. John Massie, Mariette P.C. Kemner van de Corput, Joyce Cheney, Harm A.W.M. Tiddens, Claire E. Wainwright for the Australasian Cystic Fibrosis Bronchoalveolar Lavage (ACFBAL) and Follow-up of the ACFBAL (CF-FAB) study groups

    European Respiratory Journal 55 (4) 1901694; DOI: 10.1183/13993003.01694-2019 Published 3 April 2020

• COPD

  • Open Access

    Association between adiposity measures and COPD risk in Chinese adults

    Jiachen Li, Lu Zhu, Yuxia Wei, Jun Lv, Yu Guo, Zheng Bian, Huaidong Du, Ling Yang, Yiping Chen, Yonglin Zhou, Ruqin Gao, Junshi Chen, Zhengming Chen, Weihua Cao, Canqing Yu, Liming Li on behalf of the China Kadoorie Biobank Collaborative Group

    European Respiratory Journal 55 (4) 1901899; DOI: 10.1183/13993003.01899-2019 Published 30 April 2020

• COPD and air pollution

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    Acute air pollution exposure alters neutrophils in never-smokers and at-risk humans

    Denise J. Wooding, Min Hyung Ryu, Hang Li, Neil E. Alexis, Olga Pena, Chris Carlsten Canadian Respiratory Research Network

    European Respiratory Journal 55 (4) 1901495; DOI: 10.1183/13993003.01495-2019 Published 3 April 2020

• COPD and basic science

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    α₁ Antitrypsin therapy modulates the neutrophil membrane proteome and secretome

    Mark P. Murphy, Thomas McEnery, Karen McQuillan, Oisín F. McElvaney, Oliver J. McElvaney, Sarah Landers, Orla Coleman, Anchalin Bussayajirapong, Padraig Hawkins, Michael Henry, Paula Meleady, Emer P. Reeves, Noel G. McElvaney

    European Respiratory Journal 55 (4) 1901678; DOI: 10.1183/13993003.01678-2019 Published 30 April 2020

• Basic science

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    Neuropeptide regulation of secretion and inflammation in human airway gland serous cells

    Derek B. McMahon, Ryan M. Carey, Michael A. Kohanski, Charles C.L. Tong, Peter Papagiannopoulos, Nithin D. Adappa, James N. Palmer, Robert J. Lee

    European Respiratory Journal 55 (4) 1901386; DOI: 10.1183/13993003.01386-2019 Published 16 April 2020

• Pulmonary hypertension and basic science

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    Cellular sources of interleukin-6 and associations with clinical phenotypes and outcomes in pulmonary arterial hypertension

    Catherine E. Simpson, Jenny Y. Chen, Rachel L. Damico, Paul M. Hassoun, Lisa J. Martin, Jun Yang, Melanie Nies, Megan Griffiths, Dhananjay Vaidya, Stephanie Brandal, Michael W. Pauciulo, Katie A. Lutz, Anna W. Coleman, Eric D. Austin, Dunbar D. Ivy, William C. Nichols, Allen D. Everett

    European Respiratory Journal 55 (4) 1901761; DOI: 10.1183/13993003.01761-2019 Published 16 April 2020
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    Lipids and ketones dominate metabolism at the expense of glucose control in pulmonary arterial hypertension: a hyperglycaemic clamp and metabolomics study

    Jacob T. Mey, Adithya Hari, Christopher L. Axelrod, Ciarán E. Fealy, Melissa L. Erickson, John P. Kirwan, Raed A. Dweik, Gustavo A. Heresi

    European Respiratory Journal 55 (4) 1901700; DOI: 10.1183/13993003.01700-2019 Published 9 April 2020
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    Familial pulmonary arterial hypertension by KDR heterozygous loss of function

    Mélanie Eyries, David Montani, Barbara Girerd, Nicolas Favrolt, Marianne Riou, Laurence Faivre, Grégoire Manaud, Frédéric Perros, Stefan Gräf, Nicholas W. Morrell, Marc Humbert, Florent Soubrier

    European Respiratory Journal 55 (4) 1902165; DOI: 10.1183/13993003.02165-2019 Published 3 April 2020