Extract
Sarcoidosis is a rare “old disease” first described over a century ago, known as a multifaceted systemic multiorgan inflammatory granulomatosis characterised by the presence of non-necrotising epithelioid granulomas [1, 2]. In many ways sarcoidosis remains a mysterious disease with numerous unsolved knowledge gaps. The still unknown aetiology/aetiologies of sarcoidosis is one of these gaps, i.e. the disease develops in genetically predisposed individuals following as-yet-unknown antigen exposure.
Abstract
The study of Huppertz and co-workers addresses the role of the NLRP3 inflammasome in sarcoidosis. Employing both mouse model and human samples, they provide evidence of NLPR3 inflammasome activation and increased IL-1β production in lung granulomas. http://bit.ly/32a4GsI
Footnotes
Conflict of interest: N. Riteau has nothing to disclose.
Conflict of interest: J-F. Bernaudin has nothing to disclose.
- Received January 23, 2020.
- Accepted February 10, 2020.
- Copyright ©ERS 2020