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Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension

Anna Ulrich, John Wharton, Timothy E. Thayer, Emilia M. Swietlik, Tufik R. Assad, Ankit A. Desai, Stefan Gräf, Lars Harbaum, Marc Humbert, Nicholas W. Morrell, William C. Nichols, Florent Soubrier, Laura Southgate, David-Alexandre Trégouët, Richard C. Trembath, Evan L. Brittain, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes on behalf of The NIHR BioResource – Rare Diseases Consortium, the UK PAH Cohort Study Consortium, and the US PAH Biobank Consortium
European Respiratory Journal 2020 55: 1901486; DOI: 10.1183/13993003.01486-2019
Anna Ulrich
1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK
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John Wharton
1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK
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Timothy E. Thayer
2Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA
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Emilia M. Swietlik
3Dept of Medicine, University of Cambridge, Cambridge, UK
4Pulmonary Vascular Disease Unit, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK
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Tufik R. Assad
5Williamson Country Medical Center, Franklin, TN, USA
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Ankit A. Desai
6Dept of Medicine, Indiana University, Indianapolis, IN, USA
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Stefan Gräf
3Dept of Medicine, University of Cambridge, Cambridge, UK
7NIHR BioResource – Rare Diseases, Cambridge, UK
8Dept of Haematology, University of Cambridge, Cambridge, UK
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  • ORCID record for Stefan Gräf
Lars Harbaum
1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK
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Marc Humbert
9Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Paris, France
10AP-HP, Service de Pneumologie, Centre de référence de l'hypertension pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
11INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
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Nicholas W. Morrell
3Dept of Medicine, University of Cambridge, Cambridge, UK
7NIHR BioResource – Rare Diseases, Cambridge, UK
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William C. Nichols
12Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Dept of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
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Florent Soubrier
13Sorbonne Universités, UPMC Univ. Paris 06, Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris, France
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Laura Southgate
14Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK
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David-Alexandre Trégouët
15INSERM UMR_S 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France
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Richard C. Trembath
16Division of Genetics and Molecular Medicine, King's College London, London, UK
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Evan L. Brittain
2Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA
17Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA
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Martin R. Wilkins
1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK
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Inga Prokopenko
18Dept of Clinical and Experimental Medicine, University of Surrey, Guildford, UK
19Dept of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
21These authors contributed equally
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Christopher J. Rhodes
1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK
21These authors contributed equally
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  • For correspondence: crhodes@imperial.ac.uk
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Article Information

vol. 55 no. 2
DOI 
https://doi.org/10.1183/13993003.01486-2019
PubMed 
31744833

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received July 25, 2019
  • Accepted October 29, 2019
  • Published online February 12, 2020.

Article Versions

  • previous version (November 19, 2019 - 16:05).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©ERS 2020 This version is distributed under the terms of the Creative Commons Attribution Licence 4.0.

Author Information

  1. Anna Ulrich1,
  2. John Wharton1,
  3. Timothy E. Thayer2,
  4. Emilia M. Swietlik3,4,
  5. Tufik R. Assad5,
  6. Ankit A. Desai6,
  7. Stefan Gräf3,7,8,
  8. Lars Harbaum1,
  9. Marc Humbert9,10,11,
  10. Nicholas W. Morrell3,7,
  11. William C. Nichols12,
  12. Florent Soubrier13,
  13. Laura Southgate14,
  14. David-Alexandre Trégouët15,
  15. Richard C. Trembath16,
  16. Evan L. Brittain2,17,
  17. Martin R. Wilkins1,
  18. Inga Prokopenko18,19,21 and
  19. Christopher J. Rhodes1,21⇑
  20. on behalf of The NIHR BioResource – Rare Diseases Consortium20
  21. the UK PAH Cohort Study Consortium,20
  22. and the US PAH Biobank Consortium,20
  1. 1National Heart and Lung Institute, Hammersmith Campus, Imperial College London, London, UK
  2. 2Vanderbilt University Medical Center, Division of Cardiovascular Medicine, Nashville, TN, USA
  3. 3Dept of Medicine, University of Cambridge, Cambridge, UK
  4. 4Pulmonary Vascular Disease Unit, Royal Papworth Hospital NHS Foundation Trust, Cambridge, UK
  5. 5Williamson Country Medical Center, Franklin, TN, USA
  6. 6Dept of Medicine, Indiana University, Indianapolis, IN, USA
  7. 7NIHR BioResource – Rare Diseases, Cambridge, UK
  8. 8Dept of Haematology, University of Cambridge, Cambridge, UK
  9. 9Université Paris-Sud, Faculté de Médecine, Université Paris-Saclay, Paris, France
  10. 10AP-HP, Service de Pneumologie, Centre de référence de l'hypertension pulmonaire, Hôpital Bicêtre, Le Kremlin-Bicêtre, France
  11. 11INSERM UMR_S 999, Hôpital Marie Lannelongue, Le Plessis Robinson, France
  12. 12Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Dept of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA
  13. 13Sorbonne Universités, UPMC Univ. Paris 06, Institut National pour la Santé et la Recherche Médicale (INSERM), Unité Mixte de Recherche en Santé (UMR_S) 1166, Paris, France
  14. 14Molecular and Clinical Sciences Research Institute, St George's University of London, London, UK
  15. 15INSERM UMR_S 1219, Bordeaux Population Health Research Center, University of Bordeaux, Bordeaux, France
  16. 16Division of Genetics and Molecular Medicine, King's College London, London, UK
  17. 17Vanderbilt Translational and Clinical Cardiovascular Research Center, Nashville, TN, USA
  18. 18Dept of Clinical and Experimental Medicine, University of Surrey, Guildford, UK
  19. 19Dept of Metabolism, Digestion and Reproduction, Imperial College London, London, UK
  20. 20Members listed in the supplementary material
  21. 21These authors contributed equally
  1. Christopher J. Rhodes, National Heart and Lung Institute, Medicine, Imperial College London, London, W12 0NN, UK. E-mail: crhodes{at}imperial.ac.uk
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Funding

  • NIH

    HL105333; HL146588; R01HL136603; S10RR025141
  • German Ministry for Education and Research

    01EY1103
  • CTSA

    UL1RR024975; UL1TR000445; UL1TR002243
  • American Heart Association

    13FTF16070002
  • Deutsche Forschungsgemeinschaft

    SFB1213, project A09
  • DYNAHealth

    633595
  • Wellcome Trust

    204809/Z/16/Z; WT205915
  • UK Medical Research Council

    MR/K020919/1
  • British Heart Foundation

    FS/15/59/31839; RG/08/006/25302; RG/10/16/28575; RG/13/4/30107; SP/12/12/29836

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Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension
Anna Ulrich, John Wharton, Timothy E. Thayer, Emilia M. Swietlik, Tufik R. Assad, Ankit A. Desai, Stefan Gräf, Lars Harbaum, Marc Humbert, Nicholas W. Morrell, William C. Nichols, Florent Soubrier, Laura Southgate, David-Alexandre Trégouët, Richard C. Trembath, Evan L. Brittain, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes
European Respiratory Journal Feb 2020, 55 (2) 1901486; DOI: 10.1183/13993003.01486-2019

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Mendelian randomisation analysis of red cell distribution width in pulmonary arterial hypertension
Anna Ulrich, John Wharton, Timothy E. Thayer, Emilia M. Swietlik, Tufik R. Assad, Ankit A. Desai, Stefan Gräf, Lars Harbaum, Marc Humbert, Nicholas W. Morrell, William C. Nichols, Florent Soubrier, Laura Southgate, David-Alexandre Trégouët, Richard C. Trembath, Evan L. Brittain, Martin R. Wilkins, Inga Prokopenko, Christopher J. Rhodes
European Respiratory Journal Feb 2020, 55 (2) 1901486; DOI: 10.1183/13993003.01486-2019
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