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Anti-IL5 and anti-IL5Rα therapy for clinically significant bronchiectasis with eosinophilic endotype: a case series

Jessica Rademacher, Stefanie Konwert, Jan Fuge, Sabine Dettmer, Tobias Welte, Felix C. Ringshausen
European Respiratory Journal 2020 55: 1901333; DOI: 10.1183/13993003.01333-2019
Jessica Rademacher
1Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany
2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany
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  • For correspondence: rademacher.jessica@mh-hannover.de
Stefanie Konwert
1Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany
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Jan Fuge
2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany
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  • ORCID record for Jan Fuge
Sabine Dettmer
2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany
3Dept of Diagnostic and Interventional Radiology, Hannover Medical School, Hannover, Germany
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Tobias Welte
1Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany
2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany
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Felix C. Ringshausen
1Dept of Respiratory Medicine, Hannover Medical School, Hannover, Germany
2Biomedical Research in Endstage and Obstructive Lung Disease Hannover (BREATH), German Center for Lung Research (DZL), Hannover, Germany
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  • ORCID record for Felix C. Ringshausen
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    FIGURE 1

    a) Forced expiratory volume in 1 s (FEV1); b) annualised exacerbation frequency; c) modified Medical Research Council (mMRC) dyspnoea scale; d) quality of life (QoL); e) eosinophils; and f) 24-h sputum volume at baseline and after 3 and 6 months of treatment. VAS: visual analogue scale.

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European Respiratory Journal: 55 (1)
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Anti-IL5 and anti-IL5Rα therapy for clinically significant bronchiectasis with eosinophilic endotype: a case series
Jessica Rademacher, Stefanie Konwert, Jan Fuge, Sabine Dettmer, Tobias Welte, Felix C. Ringshausen
European Respiratory Journal Jan 2020, 55 (1) 1901333; DOI: 10.1183/13993003.01333-2019

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Anti-IL5 and anti-IL5Rα therapy for clinically significant bronchiectasis with eosinophilic endotype: a case series
Jessica Rademacher, Stefanie Konwert, Jan Fuge, Sabine Dettmer, Tobias Welte, Felix C. Ringshausen
European Respiratory Journal Jan 2020, 55 (1) 1901333; DOI: 10.1183/13993003.01333-2019
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