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Late Breaking Abstract - Bronchial Rheoplasty For Treatment of Chronic Bronchitis: 6 Month Results from a Prospective Multi-Center Study

Arschang Valipour, Alvin Ing, Jonathan Williamson, Tajalli Saghaie, Daniel Steinfort, Lou Irving, Marc Fortin, Simon Martel, Gregory Snell, Eli Dabscheck, Jonathan Waldstreicher, William Krimsky, Sebastian Fernandez-Bussy
European Respiratory Journal 2019 54: RCT448; DOI: 10.1183/13993003.congress-2019.RCT448
Arschang Valipour
1Otto Wagner Spital, Wien, Austria
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  • For correspondence: arschang.valipour@wienkav.at
Alvin Ing
2Macquarie University, Sydney1, Australia
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Jonathan Williamson
3Macquarie University, Sydney, Australia
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Tajalli Saghaie
3Macquarie University, Sydney, Australia
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Daniel Steinfort
4Royal Melbourne Hospital, Melbourne, Australia
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Lou Irving
4Royal Melbourne Hospital, Melbourne, Australia
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Marc Fortin
5University of Laval, Quebec, Canada
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Simon Martel
5University of Laval, Quebec, Canada
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Gregory Snell
6The Alfred Hospital, Sydney, Australia
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Eli Dabscheck
7The Alfred, Sydney, Australia
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Jonathan Waldstreicher
8Gala Therapeutics, Melo Park, United States of America
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William Krimsky
9PCCAB Washington Square Hospital, Baltimore, United States of America
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Sebastian Fernandez-Bussy
10Clinica Alemana, Santiago, Chile
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Abstract

Introduction: Chronic bronchitis (CB) is characterized by a productive cough due to excessive mucus production in the airways, resulting in quality of life impairment and increased exacerbation risk. Bronchial Rheoplasty (BR) is a procedure in which an endobronchial catheter applies non-thermal pulsed electric fields to the airways. Preclinical studies demonstrated epithelial ablation followed by rapid regeneration of normalized epithelium. The present study evaluated the feasibility, safety and efficacy of BR in CB patients.

Methods: Prospective, multi-center study enrolling 32 patients who underwent BR under general anesthesia. Right-sided airways were treated first; the left side was treated one month later. Follow-up through 6 months included assessment of adverse events and changes in symptoms and quality of life (QOL) using the St. George’s Respiratory Questionnaire (SGRQ) and COPD Assessment Test (CAT).

Results: Bronchial rheoplasty was successfully performed in all 32 patients (62.5% male, mean age 67, post-BD FEV1 64.1±20.8%, SGRQ 59.4±15.0). Respiratory serious adverse events through 6-months included COPD exacerbation (4 patients), mucosal sail (1 patient), pleural effusion (1 patient), and unrelated lung cancer (1 patient). Mean changes from baseline to 6 months in SGRQ and CAT scores were -14.0±3.4 points (p<0.001) and -7.5±1.5 points (p< 0.0001), respectively.

Conclusion: This study provides clinical evidence of the feasibility, safety and clinical performance of BR in symptomatic CB patients. The results suggest that BR may provide improvement in symptoms and QOL for this patient population.

  • COPD
  • Bronchoscopy
  • Cough

Footnotes

Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, RCT448.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2019
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Late Breaking Abstract - Bronchial Rheoplasty For Treatment of Chronic Bronchitis: 6 Month Results from a Prospective Multi-Center Study
Arschang Valipour, Alvin Ing, Jonathan Williamson, Tajalli Saghaie, Daniel Steinfort, Lou Irving, Marc Fortin, Simon Martel, Gregory Snell, Eli Dabscheck, Jonathan Waldstreicher, William Krimsky, Sebastian Fernandez-Bussy
European Respiratory Journal Sep 2019, 54 (suppl 63) RCT448; DOI: 10.1183/13993003.congress-2019.RCT448

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Late Breaking Abstract - Bronchial Rheoplasty For Treatment of Chronic Bronchitis: 6 Month Results from a Prospective Multi-Center Study
Arschang Valipour, Alvin Ing, Jonathan Williamson, Tajalli Saghaie, Daniel Steinfort, Lou Irving, Marc Fortin, Simon Martel, Gregory Snell, Eli Dabscheck, Jonathan Waldstreicher, William Krimsky, Sebastian Fernandez-Bussy
European Respiratory Journal Sep 2019, 54 (suppl 63) RCT448; DOI: 10.1183/13993003.congress-2019.RCT448
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