Abstract
Purpose: Obstructive sleep apnoea (OSA) is associated with an increased risk for hypertension, diabetes and dyslipidaemia. Both OSA and its comorbidities are at least partly heritable, suggesting a common genetic background for them. Twin studies can help analysing the heritability of OSA and its association with comorbidities.
Methods: 47 monozygotic and 22 dizygotic adult twin pairs were recruited from the Hungarian Twin Registry (mean age 51 ± 15 years) who attended an overnight diagnostic polysomnography. Medical history was taken, blood pressure was measured, blood samples were taken for fasting glucose, total cholesterol, triglyceride, HDL-C, LDL-C and lipoprotein (a). For evaluating the heritability of OSA and its comorbidities bivariate analysis was performed with adjustment for age and gender.
Results: Significant genetic background has been found for correlations between apnoea-hypopnoea index (AHI) and triglyceride, glucose, systolic- and diastolic blood pressure (SBP, DBP) (all p<0.05), between oxygen desaturation index (ODI) and triglyceride, glucose, SBP and DBP (all p<0.05). The correlations between total sleep time 90 (TST90%) and triglyceride, total cholesterol, LDL-C, lipoprotein (a) and SBP were also heritable (all p<0.05). Only the association between ODI and DBP was environmentally determined (p=0.04).
Conclusion: OSA and its comorbidities share common genetic background. Routine screening for these comorbidities should be part of the clinical routine care.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA881.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019