Abstract
Introduction: Occupational exposures to solvents can deleterious effects on the airways. However, few studies have investigated associations between solvent exposures and airways obstruction.
Aims and Objectives: To investigate associations between occupational exposures to solvents and airways obstruction outcomes.
Methods: Subjects were selected from the French population-based CONSTANCES cohort (18-69 years) at inception. This analysis included 73,138 participants (46% men, 44% non-smokers) with information on self-reported lifetime exposures to solvents (5 specific solvents and paints/varnishes, inks/dyes), and two airway obstruction-related outcomes (z-score of FEV1/FVC and FEV1/FVC<LLN (Lower Limit of Normal)). Analyses were performed for men and women separately using multivariate linear and logistic regression models adjusting for age, smoking, pack-years, and BMI.
Results: Occupational exposure to at least one solvent was siginificantly associated with z-score FEV1/FVC among men (β=-0.02; 95%CI; -0.04,-0.002), but not with FEV1/FVC<LLN. Both men (-0.04; -0.07,-0.005) and women (-0.06;-0.11,-0.01) exposed to paints/varnishes had lower z-score FEV1/FVC than non-exposed. Exposures to ink/dyes were associated with lower z-score FEV1/FVC (-0.07;-0.13,-0.006) and higher risk of FEV1/FVC<LLN (OR; 95%CI=1.42; 1.02,1.98) in women, but not men.
Conclusion: Our results suggested that occupational exposure to some solvents was associatedwith higher risk of airway obstruction, particularly in women.
Grant Support: France-Australia Science Innovation Collaboration (FASIC) fellowship.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5237.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019