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Characteristics by physician-assigned severity of asthma, asthma+COPD and COPD patients in the NOVELTY study

Jørgen Vestbo, Helen K Reddel, Alvar Agustí, Elisabeth H Bel, Christer Janson, Barry Make, David Price, Rod Hughes, Eleni Rapsomaniki, Niklas Karlsson, Javier Nuevo, Stephen I Rennard, Alex De Giorgio-Miller, Marianna Alacqua, Maria Gerhardsson De Verdier
European Respiratory Journal 2019 54: PA5029; DOI: 10.1183/13993003.congress-2019.PA5029
Jørgen Vestbo
1The University of Manchester, Manchester, United Kingdom
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  • For correspondence: jorgen.vestbo@manchester.ac.uk
Helen K Reddel
2Woolcock Institute of Medical Research, University of Sydney, Sydney, Australia
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Alvar Agustí
3Respiratory Institute, Hospital Clinic, University of Barcelona, IDIBAPS, CIBERES, Barcelona, Spain
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Elisabeth H Bel
4Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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Christer Janson
5Department of Medical Sciences, Uppsala University, Uppsala, Sweden
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Barry Make
6National Jewish Health and University of Colorado Denver, Denver, CO, United States of America
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David Price
7Observational and Pragmatic Research Institute, Singapore and Centre of Academic Primary Care, University of Aberdeen, Aberdeen, United Kingdom
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Rod Hughes
8AstraZeneca, Cambridge, United Kingdom
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Eleni Rapsomaniki
8AstraZeneca, Cambridge, United Kingdom
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Niklas Karlsson
9AstraZeneca, Gothenburg, Sweden
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Javier Nuevo
10AstraZeneca, Madrid, Spain
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Stephen I Rennard
11Early Clinical Development, IMED Biotech Unit, AstraZeneca, Cambridge, United Kingdom
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Alex De Giorgio-Miller
8AstraZeneca, Cambridge, United Kingdom
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Marianna Alacqua
8AstraZeneca, Cambridge, United Kingdom
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Maria Gerhardsson De Verdier
9AstraZeneca, Gothenburg, Sweden
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Abstract

Insight into the criteria that physicians use to classify asthma and COPD severity is crucial to understand treatment decision-making, identify distinct patient phenotypes and drive personalised care. The NOVEL observational longiTudinal studY (NOVELTY) is a global, prospective, study of >11,000 adult patients with physician-assigned asthma and/or COPD, stratified by physician-assigned severity, from primary and specialist care.

NOVELTY aims to enhance our understanding of obstructive lung disease, including current treatment patterns and disease burden. Here we describe the baseline characteristics of the patients included in NOVELTY by physician-assigned disease severity.

By March 2018, 11,308 patients from 19 countries were enrolled (11,289 included in baseline analysis; 47% from primary care and 74% Caucasian); recruitment in China is ongoing.

Across all diagnoses, spirometry results and patient-reported outcomes were worse and exacerbations rates higher [Table 1] with increasing disease severity. From preliminary unadjusted data, blood neutrophil counts increased with severity across diagnoses.

Physician-assigned severity was associated with more patient-reported symptoms, lower lung function, more exacerbations and higher blood neutrophil counts. Future analyses will explore which features are the strongest determinants of physician-assigned severity, and any variations by diagnosis.

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Footnotes

Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5029.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2019
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Characteristics by physician-assigned severity of asthma, asthma+COPD and COPD patients in the NOVELTY study
Jørgen Vestbo, Helen K Reddel, Alvar Agustí, Elisabeth H Bel, Christer Janson, Barry Make, David Price, Rod Hughes, Eleni Rapsomaniki, Niklas Karlsson, Javier Nuevo, Stephen I Rennard, Alex De Giorgio-Miller, Marianna Alacqua, Maria Gerhardsson De Verdier
European Respiratory Journal Sep 2019, 54 (suppl 63) PA5029; DOI: 10.1183/13993003.congress-2019.PA5029

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Characteristics by physician-assigned severity of asthma, asthma+COPD and COPD patients in the NOVELTY study
Jørgen Vestbo, Helen K Reddel, Alvar Agustí, Elisabeth H Bel, Christer Janson, Barry Make, David Price, Rod Hughes, Eleni Rapsomaniki, Niklas Karlsson, Javier Nuevo, Stephen I Rennard, Alex De Giorgio-Miller, Marianna Alacqua, Maria Gerhardsson De Verdier
European Respiratory Journal Sep 2019, 54 (suppl 63) PA5029; DOI: 10.1183/13993003.congress-2019.PA5029
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