Abstract
Objective: to study the incidence of myocardial infarction, heart failure and related mortality in patients with COPD in primary care.
Methods: 437 patients with the first established diagnosis of COPD were observed during 2 years of direct observation. Men were 405 (76%), women - 129 (24%), the average age at the beginning of observation - 63,8 ±12,5 years: the degree of shortness of breath by mMRC – 2,4±0,7; scores by CAT – 24,8±10,1; by CCQ – 1,8±0,5. The comparison group was comparable by age, sex, smoking status, and comorbidity index with patients without COPD. Cox regression was used to determine whether people with COPD had an increased risk of acute myocardial infarction (AMI) and heart failure.
Results: COPD is associated with a significant increase in the risk of MI (by age and gender - adjusted OR: 2.98; 95% CI 2.71-3.09), heart failure (by age and gender-adjusted OR: 2.94; 95% CI: 2.46-3.51) and mortality (by age and gender -adjusted OR: 2.76; 95% CI: 2.45-3.12).
The analysis of the incidence of AMI from age (after adjusting for confounding by sex and smoking status and stratifying for age) revealed the greatest increase in the frequency of acute cardiovascular events in the group younger than 45 years compared with the group without COPD. The relation between the severity of obstruction and the incidence of MI in men over 60 years of age is established (adjusted relative risk 1.61 (1.09 to 2.30).
Conclusions: patients with COPD have significantly increased risk of MI, heart failure. Mortality in patients with COPD is also elevated compared to the general population.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA5020.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019