Abstract
Background: The study of the relationship between socio-demographic factors and drug resistance (DR) of new TB cases in metropolis with a significant proportion of non-permanent population will contribute to an adequate choice of treatment regimens.
Aims: (1) To characterize DR in new TB cases in Moscow. (2) To assess the relationship of socio-demographic factors and DR in new TB cases.
Methods: The study included DST and molecular tests results to I and II line drugs for 120 strains of M.tuberculosis isolated from all 120 new TB cases who were registered in 6 months of 2017 in 5 of the 12 districts of Moscow, which reflect the general situation on DR in the city.
Results: The highest DR share was observed to streptomycin (46.7%, 95% CI 44.0% - 62.5%) and to isoniazid (40.0%, 31.1% -49.3%). The smallest share of resistant strains was observed for linezolid (0.8%, 0.02% -4.56%) and cycloserine (0.8%, 0.02% - 4.56%).
The share of MDR-TB was 27.5% (19.8% - 36.4%), and XDR-TB — 5.8% (2.4% - 11.7%).
Among TB-HIV patients, there is a large share of DR strains for ethambutol (EMB) 35.0% (p = 0.0160), levofloxacin 20.0% (p = 0.005), and also for ofloxacin (OFL) 25.0% (p = 0.0019).
The share of MDR-TB was significantly higher in the age group of 35-44 g. 39.0% (p = 0.0417), and the share of XDR-TB among HIV / TB patients was significantly higher — 20% (p = 0.0147).
Multivariable logistic regression model with HIV, age groups, sex, employment status, showed that HIV is a fundamental factor for the development of DR (p<0.05): OR OFL 10,8, EMB 3,7, XDR-TB 8,1.
Conclusions: TB-HIV concentrates a certain combination of socio-demographic factors which lead to DR.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4630.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019