Abstract
We investigated the prevalence, risk and prognostic factors of sepsis in patients with viral Community-Acquired Pneumonia (vCAP), using the SEPSIS-3 definition.
Retrospective study on data prospectively collected at the Hospital Clinic of Barcelona, including adults hospitalized with vCAP between 2005 and 2017. Patients with and without sepsis were compared. The main outcome was in-hospital mortality.
Of the 2.859 patients hospitalized with CAP, 210 (7%) presented with vCAP, being Influenza virus A the pathogen most frequently isolated (72%). Sepsis affected 60% of patients with vCAP. There was no difference in the distribution of respiratory viruses and Oseltamir treatment in patients with and without sepsis. In-hospital mortality did not differ between groups. Patients with sepsis were more frequently admitted to ICU and needed mechanical ventilation (Figure 1). Among the variables associated with sepsis in the univariate analysis, age ≥65 years (odds ratio [OR] 2.77, 95% confidence interval [CI] 1.53 to 5.00) and male sex (OR 2.58, 95% CI 1.42 to 4.66) were independent risks factors for sepsis in the multivariable analysis. Sepsis was not a risk factor for in-hospital mortality in the propensity-adjusted multivariable analysis (OR 0.20, 95% CI 0.03 to 1.19).
Sepsis affected 60% of patients with a diagnosis of vCAP. Patients age ≥ 65 years old and males showed an increased risk of viral sepsis.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4533.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019
