Abstract
Objective: The aim of the study was to assess the effects of air pollutants exposure (especially PM2.5), in winter and summer, on respiratory tract function and inflammation parameters in healthy people.
Material and methods: 81 healthy people living more than 20 years in one of the most polluted city in Central Poland were examined. During the heating and non-heating season pulmonary function tests and serum cytokine (IL-1β, IL-4, IL-5, IL-6, IL-8, IL-10) concentration has been conducted. Outdoor and indoor PM2.5 and polycyclic aromatic hydrocarbons (PAHs) concentration has been measured.
Results: Statistically significant differences between PM2.5 and PAHs concentrations between the heating and non-heating seasons has been observed. Spirometric parameters in both seasons met the limits, however higher values were observed in summer. There were statistically significant (p<0.01) differences in FEV1% values between summer and winter. Differences in MEF25 and MEF75 has also been observed (with values p=0.053 and p=0.056 respectively). However there were no differences between cytokines concentration but correlations has been observed between MEF25 and concentration of IL-4 and IL-6 and between MEF50 and IL-6.
Results: The results of the study indicate that exposure to PM2.5 may be associated with subclinical decrement especially in distal lung function and cause stimulate to systemic inflammatory processes by pro-inflammatory cytokines production.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4445.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019