Abstract
Introduction: Data on remission of asthma in adults in the world is limited, and in the Russian Federation is not presented. The aim of the study was to determine clinical, functional and laboratory factors associated with remission of atopic asthma in adults.
Methods: A retrospective analysis of 313 outpatient records of adult patients with atopic asthma was carried out and then a telephone survey for 181 respondents was conducted. The median duration of observation was 8 [5;15] years. Further, 53 people with atopic asthma and 30 people without allergic diseases were examined. Clinical and laboratory (eosinophil count in peripheral blood, total immunoglobulin E and serum eosinophil cationic protein) examination, spirometry with a test of reversibility of airway obstruction were carried out.
Results: Clinical remission in adults with atopic asthma was determined in 22% of the cases; the dependence on the gender and the age of the symptoms onset was not revealed. The factors associated with remission were identified: normal body mass index (p=0,007), carrying out elimination measures (p<0,001) and allergen-specific immunotherapy (p<0,001). In the study of functional and laboratory parameters in patients with remission of atopic asthma, it was established that there were no differences in respect to the comparison group. Patients with remission differ from the group with active manifestations of the disease by normal level of the ECP (p=0,011) and negative bronchodilatation test (p = 0,047).
Conclusion: The knowledge of the possibility of remission and factors associated with its development can increase patients compliance and treatment effectiveness.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA4398.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019