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Optical coherence tomography (OCT) detects collagen within the airway wall extracellular matrix

Orestes Carpaij, A.W.M. Goorsenberg, D.M. De Bruin, R.M. Van Den Elzen, M.C. Nawijn, H.A.M. Kerstjens, M. Van Den Berge, J.T. Annema, J.K. Burgess, P.I. Bonta
European Respiratory Journal 2019 54: PA3169; DOI: 10.1183/13993003.congress-2019.PA3169
Orestes Carpaij
1University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands
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  • For correspondence: o.a.carpaij@umcg.nl
A.W.M. Goorsenberg
2Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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D.M. De Bruin
3Department of Biomedical Engineering & Physics Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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R.M. Van Den Elzen
3Department of Biomedical Engineering & Physics Radiology, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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M.C. Nawijn
1University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands
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H.A.M. Kerstjens
1University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands
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M. Van Den Berge
1University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands
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J.T. Annema
2Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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J.K. Burgess
1University of Groningen, University Medical Center Groningen, Groningen Research Institute for Asthma and COPD (GRIAC), Groningen, Netherlands
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P.I. Bonta
2Department of Respiratory Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands
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Abstract

Introduction: Airway diseases are characterized by structural airway remodeling, including extracellular matrix (ECM) changes. Although a key feature, no diagnostic test currently assesses airway remodeling other than invasive airway biopsies. Real-time optical coherence tomography (OCT) generates infrared-based cross-sectional images of airway segments. Previously we reported that OCT identifies and quantifies airway wall layers. We hypothesized that OCT is able to detect collagen deposition areas within the airway wall ECM.

Methods: In 5 lobectomy specimens 13 airways were dissected, marked with needles for matching histology and imaged by OCT. Sections were stained for total collagen (TC; pico sirius red) and collagen type I A1 (CA1; antibody). Color deconvolution was used to quantify TC or CA1 area (ImageJ). OCT images were segmented by light scattering intensity after thresholding, attenuation and roll-off correction. Areas were measured in mm2 and defined as % of the airway wall.

Results: 23 airway OCT images with matched histology sections stained for TC and CA1 were analyzed (Fig. 1A-F). OCT area showed a significant correlation with TC area (r=0.52, p=0.01) and a non-significant correlation with CA1 area (r=0.31; p=0.12).

Figure1
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Conclusion: OCT scattering area appears to correspond to collagen within the airway wall. Therefore, OCT may represent an imaging technique of choice to assess airway remodeling.

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Footnotes

Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA3169.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

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Optical coherence tomography (OCT) detects collagen within the airway wall extracellular matrix
Orestes Carpaij, A.W.M. Goorsenberg, D.M. De Bruin, R.M. Van Den Elzen, M.C. Nawijn, H.A.M. Kerstjens, M. Van Den Berge, J.T. Annema, J.K. Burgess, P.I. Bonta
European Respiratory Journal Sep 2019, 54 (suppl 63) PA3169; DOI: 10.1183/13993003.congress-2019.PA3169

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Optical coherence tomography (OCT) detects collagen within the airway wall extracellular matrix
Orestes Carpaij, A.W.M. Goorsenberg, D.M. De Bruin, R.M. Van Den Elzen, M.C. Nawijn, H.A.M. Kerstjens, M. Van Den Berge, J.T. Annema, J.K. Burgess, P.I. Bonta
European Respiratory Journal Sep 2019, 54 (suppl 63) PA3169; DOI: 10.1183/13993003.congress-2019.PA3169
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