Abstract
Introduction: Chronic obstructive pulmonary disease (COPD) remains a major burden with no clinically applicable biomarkers. Red cell distribution width (RDW) has been reported to be associated with the outcome of other respiratory diseases.
Aim: To investigate the association of RDW with respiratory acidosis leading to the application of non invasive mechanical ventilation (NIMV) in acute exacerbation of COPD (AECOPD).
Methods: Patients with AECOPD admitted to our pulmonary department during 2018 were included in the study. Patients were divided based on PCO2 levels (cut-off: 45 mmHg) and the need of NIMV application or not. Kolmogorov-Smirnov test was used to assess the distribution of normality. Means were compared using t-test.
Results: One hundred sixty patients were enrolled (M/F 95/65, median age 71.00 years, mean FEV1 ± SD = 47.74±29.29). Fifty seven had PCO2>45 mmHg and 33 of them were in need of NIMV. RDW for patients with PCO2>45 mmHg and PCO2<45 mmHg was 14.83 ±1.78 and 13.6±1.86 (p<0.001), respectively. RDW for patients in need of NIMV or not was 15.17±1.80 and 13.63±2.23, respectively (p<0.001) [Figure 1].
Conclusion: RDW is an easily obtained blood biomarker and could serve as a predictor of need of NIMV application in AECOPD.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2589.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019