Abstract
Rationale: Postoperative pulmonary complications (PPCs) continue to be a leading cause of increased morbidity and mortality after cardiac surgery. Although various risk factors have been identified, reports on the association between sleep-disordered breathing (SDB) and PPCs remain inconclusive.
Objective: This study ought to determine the incidence of PPCs and to identify risk factors for major pulmonary complications (MPCs) in patients with and without SDB.
Methods: This sub-analysis of the ongoing prospective observational study CONSIDER AF (NCT02877745) examined risk factors for MPCs in 249 patients undergoing elective cardiac surgery. The presence and type of SDB were assessed the night prior to cardiac surgery using portable SDB-monitoring. MPCs defined as respiratory failure, and/or ARDS, and/or pneumonia, and/or pulmonary embolism were prospectively assessed.
Results: MPCs were diagnosed in 16% of all patients and occurred significantly more often in patients with SDB compared to patients without SDB (25% vs. 7%, p=0.002). Among patients with SDB, patients with central sleep apnoea were significantly more prone to suffer from MPCs than patients with obstructive sleep apnoea (32% vs. 16%, p=0.033). Multivariable logistic regression analysis showed that central sleep apnoea (Odd’s ratio, OR [95% confidence interval, CI]: 3.01 [1.12; 8.10], p=0.029), heart failure (5.49 [1.94; 15.55], p=0.001), and history of stroke (5.35 [1.43; 20.02], p=0.013) were independently associated with MPCs.
Conclusion: Amongst established risk factors for PPCs, central sleep apnoea was independently associated with MPCs.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2280.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019