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Comparison of postoperative immunological changes between intubated and non-intubated patients during lung cancer resection surgery

Soo-A Oh, Joonpyo Jeon, Wonjung Hwang
European Respiratory Journal 2019 54: PA2215; DOI: 10.1183/13993003.congress-2019.PA2215
Soo-A Oh
1Seoul St. Mary’s hospital, Seoul, Republic of Korea
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  • For correspondence: ameoab97@naver.com
Joonpyo Jeon
1Seoul St. Mary’s hospital, Seoul, Republic of Korea
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Wonjung Hwang
1Seoul St. Mary’s hospital, Seoul, Republic of Korea
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Abstract

Background: Postoperative immunological changes have an impact on oncological outcomes. Unlike conventional thoracic surgery performed under general anesthesia with tracheal intubation, non-intubated thoracic surgery with sedation and regional anesthesia has been performed recently. The aim of this study was to compare postoperative immunological changes between intubated and non-intubated patients who underwent lung cancer resection surgery.

Methods: This prospective randomized-controlled study included 30 patients who underwent surgical resection for stage I non-small cell lung cancer. Blood samples for cytokine analysis were collected just before induction, at the 1 hour and 24 hours after surgery. Levels of the pro-inflammatory cytokine interleukin(IL)-6 and anti-inflammatory cytokines IL-10 were measured using quantitative sandwich enzyme immunoassay kits.

Results: There was no significant difference in preoperative values between two groups. Significant increase in IL-6 and decrease in IL-10 were observed at all time points after surgery in both groups. IL-6 at 24 hours after surgery was significantly lower in non-intubated patients compared with intubated patients (20.8 [16.0-24.4] vs. 28.4 [21.2-41.6], P=0.04). Postoperative levels of IL-10 were not different between two groups.

Conclusion: Postoperative immunological change was lesser in non-intubated patients compared with intubated patients during lung cancer resection surgery.

  • Lung cancer
  • RCT (Randomized Controlled Trial)

Footnotes

Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2215.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2019
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Comparison of postoperative immunological changes between intubated and non-intubated patients during lung cancer resection surgery
Soo-A Oh, Joonpyo Jeon, Wonjung Hwang
European Respiratory Journal Sep 2019, 54 (suppl 63) PA2215; DOI: 10.1183/13993003.congress-2019.PA2215

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Comparison of postoperative immunological changes between intubated and non-intubated patients during lung cancer resection surgery
Soo-A Oh, Joonpyo Jeon, Wonjung Hwang
European Respiratory Journal Sep 2019, 54 (suppl 63) PA2215; DOI: 10.1183/13993003.congress-2019.PA2215
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