Abstract
Background: Postoperative immunological changes have an impact on oncological outcomes. Unlike conventional thoracic surgery performed under general anesthesia with tracheal intubation, non-intubated thoracic surgery with sedation and regional anesthesia has been performed recently. The aim of this study was to compare postoperative immunological changes between intubated and non-intubated patients who underwent lung cancer resection surgery.
Methods: This prospective randomized-controlled study included 30 patients who underwent surgical resection for stage I non-small cell lung cancer. Blood samples for cytokine analysis were collected just before induction, at the 1 hour and 24 hours after surgery. Levels of the pro-inflammatory cytokine interleukin(IL)-6 and anti-inflammatory cytokines IL-10 were measured using quantitative sandwich enzyme immunoassay kits.
Results: There was no significant difference in preoperative values between two groups. Significant increase in IL-6 and decrease in IL-10 were observed at all time points after surgery in both groups. IL-6 at 24 hours after surgery was significantly lower in non-intubated patients compared with intubated patients (20.8 [16.0-24.4] vs. 28.4 [21.2-41.6], P=0.04). Postoperative levels of IL-10 were not different between two groups.
Conclusion: Postoperative immunological change was lesser in non-intubated patients compared with intubated patients during lung cancer resection surgery.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2215.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019
