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Bronchial Rheoplasty Increases Distal Airway Volume in Chronic Bronchitis

Victor Kim, William Krimsky, Brett Bannan, Michelle Machuca, Wim Vos, Jan De Backer, Arshang Valipour, Alvin Ing, Jonathan Williamson, Tajalli Saghaie, Daniel Steinfort, Gregory Snell, Sebastian Fernandez-Bussy, Eli Dabscheck, Lou Irving, Simon Martel, Marc Fortin, Jonathan Waldstreicher
European Respiratory Journal 2019 54: PA2040; DOI: 10.1183/13993003.congress-2019.PA2040
Victor Kim
1Lewis Katz School of Medicine at Temple University, Philadelphia, United States of America
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  • For correspondence: victor.kim@tuhs.temple.edu
William Krimsky
2MedStar Franklin Square Medical Center, Baltimore, United States of America
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Brett Bannan
3Gala Therapeutics, Menlo Park, United States of America
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Michelle Machuca
3Gala Therapeutics, Menlo Park, United States of America
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Wim Vos
4FLUIDDA nv, Kontich, Belgium
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Jan De Backer
4FLUIDDA nv, Kontich, Belgium
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Arshang Valipour
5Otto Wagner Spital, Vienna, Austria
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Alvin Ing
6Macquarie University, Sydney, Australia
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Jonathan Williamson
6Macquarie University, Sydney, Australia
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Tajalli Saghaie
6Macquarie University, Sydney, Australia
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Daniel Steinfort
7Royal Melbourne Hospital, Melbourne, Australia
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Gregory Snell
8The Alfred Hospital, Melbourne, Australia
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Sebastian Fernandez-Bussy
9Clinica Alemana, Santiago, Chile
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Eli Dabscheck
8The Alfred Hospital, Melbourne, Australia
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Lou Irving
7Royal Melbourne Hospital, Melbourne, Australia
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Simon Martel
10IUCPQ, University of Laval, Quebec, Canada
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Marc Fortin
10IUCPQ, University of Laval, Quebec, Canada
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Jonathan Waldstreicher
3Gala Therapeutics, Menlo Park, United States of America
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Abstract

Background: Bronchial Rheoplasty is a novel bronchoscopic therapy for chronic bronchitis (CB) which uses pulsed electric fields to ablate mucus producing cells in the airways to reduce excess mucus production and inflammation. Functional respiratory imaging (FRI) has been used to assess lobar and total lung volumes, airway counts, volumes and resistance. The effects of Bronchial Rheoplasty on total airway count (TAC) and distal airway volume (DAV) assessed by FRI are unknown. We hypothesized that Bronchial Rheoplasty would increase DAV and TAC in CB patients by decreasing airway mucus obstruction and inflammation.

Methods: We conducted a retrospective analysis of 27 CB patients enrolled in the first clinical trial of Bronchial Rheoplasty. Lung function tests, SGRQ, and CAT scores were obtained at baseline and 3 months post-intervention. FRI was performed at baseline and at 3 months after completion of bilateral Rheoplasty. DAV and TAC were compared pre- and post-intervention using paired t tests.

Results: DAV pre- and post-Rheoplasty were 8.87±5.09mL and 10.82±6.92mL, respectively (mean diff 1.95mL, 95% CI 0.66, 3.23, p=0.005, 21.9% increase). Similar trends were seen in TAC (pre- and post-Rheoplasty 115.6±44.8 airways and 131.2±59.9 airways, mean diff 15.7 airways, 95% CI 1.4, 30.0, p=0.033, 13.5% increase). Changes in DAV and TAC were accompanied by improvements in SGRQ (-17.2±20.0 points, 95% CI -24.9, -9.6, p<0.0001) and CAT scores (-8.9±7.6 points, 95% CI -11.8, -6.1, p<0.0001).

Conclusions: Bronchial Rheoplasty resulted in increased DAV and TAC, likely due to a reduction in mucus obstruction allowing for greater distal ventilation. These changes were accompanied by improvements in quality of life.

  • Bronchoscopy
  • COPD - management
  • Treatments

Footnotes

Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2040.

This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).

  • Copyright ©the authors 2019
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Bronchial Rheoplasty Increases Distal Airway Volume in Chronic Bronchitis
Victor Kim, William Krimsky, Brett Bannan, Michelle Machuca, Wim Vos, Jan De Backer, Arshang Valipour, Alvin Ing, Jonathan Williamson, Tajalli Saghaie, Daniel Steinfort, Gregory Snell, Sebastian Fernandez-Bussy, Eli Dabscheck, Lou Irving, Simon Martel, Marc Fortin, Jonathan Waldstreicher
European Respiratory Journal Sep 2019, 54 (suppl 63) PA2040; DOI: 10.1183/13993003.congress-2019.PA2040

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Bronchial Rheoplasty Increases Distal Airway Volume in Chronic Bronchitis
Victor Kim, William Krimsky, Brett Bannan, Michelle Machuca, Wim Vos, Jan De Backer, Arshang Valipour, Alvin Ing, Jonathan Williamson, Tajalli Saghaie, Daniel Steinfort, Gregory Snell, Sebastian Fernandez-Bussy, Eli Dabscheck, Lou Irving, Simon Martel, Marc Fortin, Jonathan Waldstreicher
European Respiratory Journal Sep 2019, 54 (suppl 63) PA2040; DOI: 10.1183/13993003.congress-2019.PA2040
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