Abstract
Background: OSAS was associated with upper and lower respiratory tracts inflammation, Fractional exhaled nitric oxide (FeNO) proposed as a marker of airway inflammation, few studies were done on impact of continuous positive airway pressure (CPAP) on FeNO .
Aim of the Work: to study the impact of continues positive airway pressure therapy on exhaled NO as marker of inflammation in obstructive sleep apnea syndrome.
Patient and Methods: This study is acase control study including (27) participants were newly diagnosed as OSA and (9) control recruited from sleep outpatient clinic, full night PSG was done, fractional exhaled nitric oxide and HsCRP were measured next morning of PSG, CPAP for moderate to severe OSA patient was advised with measurement of FENOand HsCRP after 3months of CPAP
Results: there were statistically significant higher FeNO and S.CRP in OSA patients versus control group. there were statistically significant decrease in both FeNO and serum CRP after 3months of CPAP therapy.
Conclusion: upper airway and systemic inflammation are present in OSAS, indicated by increasing both FENO and serum CRP, CPAP therapy reduced Fractional exhaled nitric oxide(FeNO)level and S.CRP in OSA patients
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA2022.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019