Abstract
Background: Epidemiological data supports a strong correlation between Idiopathic Pulmonary Fibrosis (IPF) and lung cancer. Data regarding adenocarcinoma (ADC) histological subtypes in IPF patients is limited.
Aim: To describe the subtypes of IPF-associated ADC.
Patients and Methods: This was a unicentric retrospective study. We identified 45 cases with IPF and lung cancer among 360 in total with IPF between 2009-2018. Most cases (77.7%, n=35) were non-small cell lung cancer (16 squamous, 11 ADC, 2 adenosquamous, 1 sarcomatoid, 5 non-specified). In 8 ADC cases data was available for further characterization (Group A). Data was compared with data derived from a historical cohort.
Results: Baseline characteristics of patients (Group A) were: mean age±SD=71.1±8.1, 8 males, meanFVC±SD= 84±16.6, meanDLCO±SD= 63±11.9. Median survival was 24.5 months. Subtypes were: lepidic=2, solid=2, acinar=1, minimally invasive ADC=1, fetal=1, ADC with enteric features=1 (Table 1). Statistical comparison to a historical cohort of 500 ADCs from our center revealed: higher frequency of enteric and fetal subtypes among IPF-ADC (enteric: 9.1%vs0.2%, fetal: 9.1%vs0.2%) and lower frequency (9.1%vs41.4%) of acinar subtype (p<0.05).
Conclusions: Different distribution of histologic subtypes among IPF-ADC indicates a potentially distinct origin and pathogenesis compared to non-IPF-ADC.
Footnotes
Cite this article as: European Respiratory Journal 2019; 54: Suppl. 63, PA1310.
This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only).
- Copyright ©the authors 2019
