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Hyperinsulinemia due to altered insulin secretion contributes to insulin resistance in chronic intermittent hypoxia independently of obesity

Joana F. Sacramento, Bernardete F. Melo, Elena Olea, Ana Obeso, Asuncion Rocher, Tiago Rodrigues, Jesus Prieto-Lloret, Sara Yubero, Emilia C. Monteiro, Paulo Matafome, Silva V. Conde
European Respiratory Journal 2019 54: OA4935; DOI: 10.1183/13993003.congress-2019.OA4935
Joana F. Sacramento
1CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal
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  • For correspondence: joana.sacramento@nms.unl.pt
Bernardete F. Melo
1CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal
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Elena Olea
2Department of Nursing, University of Valladolid, School of Nursing, Valladolid, Spain and Institute of Molecular Biology and Genetics, CIBER Enfermedades Respiratorias, CIBERES, Institute of Salud Carlos III, Valladolid, Spain
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Ana Obeso
3Department of Biochemistry and Molecular Biology and Physiology, University of Valladolid, School of Medicine and Institute of Molecular Biology and Genetics, CIBER Enfermedades Respiratorias, CIBERES, Institute of Salud Carlos III, Valladolid, Spain
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Asuncion Rocher
3Department of Biochemistry and Molecular Biology and Physiology, University of Valladolid, School of Medicine and Institute of Molecular Biology and Genetics, CIBER Enfermedades Respiratorias, CIBERES, Institute of Salud Carlos III, Valladolid, Spain
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Tiago Rodrigues
4Institute of Physiology and Institute of Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
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Jesus Prieto-Lloret
3Department of Biochemistry and Molecular Biology and Physiology, University of Valladolid, School of Medicine and Institute of Molecular Biology and Genetics, CIBER Enfermedades Respiratorias, CIBERES, Institute of Salud Carlos III, Valladolid, Spain
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Sara Yubero
3Department of Biochemistry and Molecular Biology and Physiology, University of Valladolid, School of Medicine and Institute of Molecular Biology and Genetics, CIBER Enfermedades Respiratorias, CIBERES, Institute of Salud Carlos III, Valladolid, Spain
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Emilia C. Monteiro
1CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal
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Paulo Matafome
5Institute of Physiology and Institute of Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra and Instituto Politécnico de Coimbra, Coimbra Health School, Coimbra, Portugal
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Silva V. Conde
1CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal
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Article Information

vol. 54 no. suppl 63
DOI 
https://doi.org/10.1183/13993003.congress-2019.OA4935

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Published online November 21, 2019.

Copyright & Usage 
Copyright ©the authors 2019

Author Information

  1. Joana F. Sacramento1⇑,
  2. Bernardete F. Melo1,
  3. Elena Olea2,
  4. Ana Obeso3,
  5. Asuncion Rocher3,
  6. Tiago Rodrigues4,
  7. Jesus Prieto-Lloret3,
  8. Sara Yubero3,
  9. Emilia C. Monteiro1,
  10. Paulo Matafome5 and
  11. Silva V. Conde1
  1. 1CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal
  2. 2Department of Nursing, University of Valladolid, School of Nursing, Valladolid, Spain and Institute of Molecular Biology and Genetics, CIBER Enfermedades Respiratorias, CIBERES, Institute of Salud Carlos III, Valladolid, Spain
  3. 3Department of Biochemistry and Molecular Biology and Physiology, University of Valladolid, School of Medicine and Institute of Molecular Biology and Genetics, CIBER Enfermedades Respiratorias, CIBERES, Institute of Salud Carlos III, Valladolid, Spain
  4. 4Institute of Physiology and Institute of Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra, Coimbra, Portugal
  5. 5Institute of Physiology and Institute of Clinical and Biomedical Research (iCBR), Faculty of Medicine, University of Coimbra and Instituto Politécnico de Coimbra, Coimbra Health School, Coimbra, Portugal
  1. Joana F. Sacramento, CEDOC, NOVA Medical School, Faculdade de Ciências Médicas, Universidade NOVA de Lisboa, Lisbon, Portugal. E-mail: joana.sacramento{at}nms.unl.pt

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Hyperinsulinemia due to altered insulin secretion contributes to insulin resistance in chronic intermittent hypoxia independently of obesity
Joana F. Sacramento, Bernardete F. Melo, Elena Olea, Ana Obeso, Asuncion Rocher, Tiago Rodrigues, Jesus Prieto-Lloret, Sara Yubero, Emilia C. Monteiro, Paulo Matafome, Silva V. Conde
European Respiratory Journal Sep 2019, 54 (suppl 63) OA4935; DOI: 10.1183/13993003.congress-2019.OA4935

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Hyperinsulinemia due to altered insulin secretion contributes to insulin resistance in chronic intermittent hypoxia independently of obesity
Joana F. Sacramento, Bernardete F. Melo, Elena Olea, Ana Obeso, Asuncion Rocher, Tiago Rodrigues, Jesus Prieto-Lloret, Sara Yubero, Emilia C. Monteiro, Paulo Matafome, Silva V. Conde
European Respiratory Journal Sep 2019, 54 (suppl 63) OA4935; DOI: 10.1183/13993003.congress-2019.OA4935
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