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Monocytes and macrophages in chronic sarcoidosis pathology

Simon D. Fraser, Simon P. Hart
European Respiratory Journal 2019 54: 1901626; DOI: 10.1183/13993003.01626-2019
Simon D. Fraser
Respiratory Research Group, Hull York Medical School, Castle Hill Hospital, Cottingham, UK
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  • For correspondence: s.hart@hull.ac.uk
Simon P. Hart
Respiratory Research Group, Hull York Medical School, Castle Hill Hospital, Cottingham, UK
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Extract

Kaiser et al. [1] make a compelling case for T-lymphocytes in the pathogenesis of sarcoidosis, particularly when considering the initiation of granulomatous inflammation and patients with acute, self-resolving sarcoidosis (Lofgren's syndrome). However, in some situations it seems that T-cells are less important. For example, SCID (severe combined immunodeficient) mice, which have no lymphocytes, develop macrophage-rich granulomas when infected with mycobacteria [2]. In clinical practice, powerful suppression of T-lymphocytes with anti-rejection medication cannot prevent recurrence of granulomas in one third of patients who have undergone lung transplantation for pulmonary sarcoidosis [3].

Abstract

Don't neglect monocytes and macrophages as drivers of chronic sarcoidosis http://bit.ly/2L2I5Yp

Footnotes

  • Conflict of interest: S.D. Fraser reports grants from SarcoidosisUK/British Lung Foundation and Foundation for Sarcoidosis Research, outside the submitted work.

  • Conflict of interest: S.P. Hart reports grants from SarcoidosisUK/British Lung Foundation and Foundation for Sarcoidosis Research, outside the submitted work.

  • Received August 15, 2019.
  • Accepted August 23, 2019.
  • Copyright ©ERS 2019
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Monocytes and macrophages in chronic sarcoidosis pathology
Simon D. Fraser, Simon P. Hart
European Respiratory Journal Nov 2019, 54 (5) 1901626; DOI: 10.1183/13993003.01626-2019

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Monocytes and macrophages in chronic sarcoidosis pathology
Simon D. Fraser, Simon P. Hart
European Respiratory Journal Nov 2019, 54 (5) 1901626; DOI: 10.1183/13993003.01626-2019
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