Extract
Kaiser et al. [1] make a compelling case for T-lymphocytes in the pathogenesis of sarcoidosis, particularly when considering the initiation of granulomatous inflammation and patients with acute, self-resolving sarcoidosis (Lofgren's syndrome). However, in some situations it seems that T-cells are less important. For example, SCID (severe combined immunodeficient) mice, which have no lymphocytes, develop macrophage-rich granulomas when infected with mycobacteria [2]. In clinical practice, powerful suppression of T-lymphocytes with anti-rejection medication cannot prevent recurrence of granulomas in one third of patients who have undergone lung transplantation for pulmonary sarcoidosis [3].
Abstract
Don't neglect monocytes and macrophages as drivers of chronic sarcoidosis http://bit.ly/2L2I5Yp
Footnotes
Conflict of interest: S.D. Fraser reports grants from SarcoidosisUK/British Lung Foundation and Foundation for Sarcoidosis Research, outside the submitted work.
Conflict of interest: S.P. Hart reports grants from SarcoidosisUK/British Lung Foundation and Foundation for Sarcoidosis Research, outside the submitted work.
- Received August 15, 2019.
- Accepted August 23, 2019.
- Copyright ©ERS 2019