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Nontuberculosis mycobacteria infections: would there be pharmacodynamics without pharmacokinetics?

Hannah Yejin Kim, Vitali Sintchenko, Jan-Willem Alffenaar
European Respiratory Journal 2019 54: 1901508; DOI: 10.1183/13993003.01508-2019
Hannah Yejin Kim
Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaWestmead Hospital, Sydney, Australia
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Vitali Sintchenko
Sydney Medical School, The University of Sydney, Sydney, AustraliaCentenary Institute, The University of Sydney, Sydney, AustraliaCentre for Infectious Diseases and Microbiology–Public Health, Westmead Hospital, Sydney, Australia
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Jan-Willem Alffenaar
Sydney Pharmacy School, Faculty of Medicine and Health, The University of Sydney, Sydney, AustraliaWestmead Hospital, Sydney, Australia
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Extract

We read with great interest the recent publication by Kwak et al. [1] involving a meta-analysis of studies reporting treatment outcomes for Mycobacterium abscessus pulmonary disease (MAB-PD). The authors should be commended for identifying the association between azithromycin, amikacin and imipenem, and improved clinical outcome in MAB-PD.

Abstract

A combination of pharmacokinetics and pharmacodynamics is required to evaluate the efficacy of antimicrobial drugs in the treatment of Mycobacterium abscessus http://bit.ly/2OGwS3C

Footnotes

  • Conflict of interest: H.Y. Kim has nothing to disclose.

  • Conflict of interest: V. Sintchenko has nothing to disclose.

  • Conflict of interest: J-W. Alffenaar has nothing to disclose.

  • Received July 30, 2019.
  • Accepted August 1, 2019.
  • Copyright ©ERS 2019
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Vol 54 Issue 5 Table of Contents
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Nontuberculosis mycobacteria infections: would there be pharmacodynamics without pharmacokinetics?
Hannah Yejin Kim, Vitali Sintchenko, Jan-Willem Alffenaar
European Respiratory Journal Nov 2019, 54 (5) 1901508; DOI: 10.1183/13993003.01508-2019

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Nontuberculosis mycobacteria infections: would there be pharmacodynamics without pharmacokinetics?
Hannah Yejin Kim, Vitali Sintchenko, Jan-Willem Alffenaar
European Respiratory Journal Nov 2019, 54 (5) 1901508; DOI: 10.1183/13993003.01508-2019
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