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Diagnostic value of BAL lymphocytosis in patients with indeterminate for usual interstitial pneumonia imaging pattern

Vasilios Tzilas, Argyrios Tzouvelekis, Evangelos Bouros, Theodoros Karampitsakos, Maria Ntasiou, Mattheos Katsaras, Ulrich Costabel, Athol Wells, Demosthenes Bouros
European Respiratory Journal 2019 54: 1901144; DOI: 10.1183/13993003.01144-2019
Vasilios Tzilas
1First Academic Dept of Pneumonology, Interstitial Lung Diseases Unit, Hospital for Diseases of the Chest, “Sotiria”, Medical School, National and Kapodistrian University of Athens, Athens, Greece
6Both authors contributed equally
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Argyrios Tzouvelekis
1First Academic Dept of Pneumonology, Interstitial Lung Diseases Unit, Hospital for Diseases of the Chest, “Sotiria”, Medical School, National and Kapodistrian University of Athens, Athens, Greece
6Both authors contributed equally
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Evangelos Bouros
1First Academic Dept of Pneumonology, Interstitial Lung Diseases Unit, Hospital for Diseases of the Chest, “Sotiria”, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Theodoros Karampitsakos
2Fifth Dept of Pneumonology, Hospital for Chest Diseases “Sotiria”, Athens, Greece
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  • ORCID record for Theodoros Karampitsakos
Maria Ntasiou
1First Academic Dept of Pneumonology, Interstitial Lung Diseases Unit, Hospital for Diseases of the Chest, “Sotiria”, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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Mattheos Katsaras
3Sixth Dept of Pneumonology, Hospital for Chest Diseases “Sotiria”, Athens, Greece
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Ulrich Costabel
4Interstitial and Rare Lung Disease Unit, Ruhrlandklinik, University Hospital, Essen, Germany
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Athol Wells
5Interstitial Lung Disease Unit, Royal Brompton Hospital, London, UK
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Demosthenes Bouros
1First Academic Dept of Pneumonology, Interstitial Lung Diseases Unit, Hospital for Diseases of the Chest, “Sotiria”, Medical School, National and Kapodistrian University of Athens, Athens, Greece
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  • For correspondence: debouros@gmail.com
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Extract

The introduction of antifibrotic agents to clinical practice and the need to better define patient populations for future clinical trials highlight the importance of accurate diagnosis. The main unmet need lies within the population of patients with fibrotic interstitial lung disease (f-ILD) and indeterminate for usual interstitial pneumonia (UIP) pattern on high-resolution computed tomography (HRCT). The differential diagnosis mainly includes idiopathic pulmonary fibrosis (IPF), nonspecific interstitial pneumonia (NSIP), ILD associated with occult collagen tissue disease and, most notably, chronic hypersensitivity pneumonitis.

Abstract

BALF lymphocytosis is a valuable complementary tool in patients with fibrotic interstitial lung disease (f-ILD) and indeterminate-for-UIP pattern on HRCT http://bit.ly/2nCTkOh

Footnotes

  • Conflict of interest: V. Tzilas has nothing to disclose.

  • Conflict of interest: A. Tzouvelekis has nothing to disclose.

  • Conflict of interest: E. Bouros has nothing to disclose.

  • Conflict of interest: T. Karampitsakos has nothing to disclose.

  • Conflict of interest: M. Ntasiou has nothing to disclose.

  • Conflict of interest: M. Katsaras has nothing to disclose.

  • Conflict of interest: U. Costabel has nothing to disclose.

  • Conflict of interest: A. Wells reports personal fees from Bayer AG, Roche and Boehringer Ingelheim, during the conduct of the study.

  • Conflict of interest: D. Bouros reports grants, personal fees and non-financial support from Boehringer Ingelheim and Roche, and grants from Elpen, outside the submitted work.

  • Received March 11, 2019.
  • Accepted July 7, 2019.
  • Copyright ©ERS 2019
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Vol 54 Issue 5 Table of Contents
European Respiratory Journal: 54 (5)
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Diagnostic value of BAL lymphocytosis in patients with indeterminate for usual interstitial pneumonia imaging pattern
Vasilios Tzilas, Argyrios Tzouvelekis, Evangelos Bouros, Theodoros Karampitsakos, Maria Ntasiou, Mattheos Katsaras, Ulrich Costabel, Athol Wells, Demosthenes Bouros
European Respiratory Journal Nov 2019, 54 (5) 1901144; DOI: 10.1183/13993003.01144-2019

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Diagnostic value of BAL lymphocytosis in patients with indeterminate for usual interstitial pneumonia imaging pattern
Vasilios Tzilas, Argyrios Tzouvelekis, Evangelos Bouros, Theodoros Karampitsakos, Maria Ntasiou, Mattheos Katsaras, Ulrich Costabel, Athol Wells, Demosthenes Bouros
European Respiratory Journal Nov 2019, 54 (5) 1901144; DOI: 10.1183/13993003.01144-2019
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