Skip to main content

Main menu

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
  • Alerts
  • Podcasts
  • Subscriptions
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

User menu

  • Log in
  • Subscribe
  • Contact Us
  • My Cart

Search

  • Advanced search
  • ERS Publications
    • European Respiratory Journal
    • ERJ Open Research
    • European Respiratory Review
    • Breathe
    • ERS Books
    • ERS publications home

Login

European Respiratory Society

Advanced Search

  • Home
  • Current issue
  • ERJ Early View
  • Past issues
  • For authors
    • Instructions for authors
    • Submit a manuscript
    • Author FAQs
  • Alerts
  • Podcasts
  • Subscriptions

Airway morphometry in COPD with bronchiectasis: a view on all airway generations

Stephanie Everaerts, John E. McDonough, Stijn E. Verleden, Iván Josipovic, Matthieu Boone, Adriana Dubbeldam, Carolien Mathyssen, Jef Serré, Lieven J. Dupont, Ghislaine Gayan-Ramirez, Johny Verschakelen, James C. Hogg, Geert M. Verleden, Bart M. Vanaudenaerde, Wim Janssens
European Respiratory Journal 2019 54: 1802166; DOI: 10.1183/13993003.02166-2018
Stephanie Everaerts
Laboratory of Pneumology, Dept of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, BelgiumDept of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Stephanie Everaerts
John E. McDonough
Laboratory of Pneumology, Dept of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stijn E. Verleden
Laboratory of Pneumology, Dept of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Iván Josipovic
Dept of Physics and Astronomy, UGCT, Radiation Physics, Ghent University, Gent, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthieu Boone
Dept of Physics and Astronomy, UGCT, Radiation Physics, Ghent University, Gent, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Adriana Dubbeldam
Dept of Radiology, University Hospitals Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Carolien Mathyssen
Laboratory of Pneumology, Dept of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jef Serré
Laboratory of Pneumology, Dept of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lieven J. Dupont
Laboratory of Pneumology, Dept of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, BelgiumDept of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Ghislaine Gayan-Ramirez
Laboratory of Pneumology, Dept of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Johny Verschakelen
Dept of Radiology, University Hospitals Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James C. Hogg
University of British Columbia James Hogg Research Centre, St Paul's Hospital, Vancouver, BC, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Geert M. Verleden
Laboratory of Pneumology, Dept of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, BelgiumDept of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bart M. Vanaudenaerde
Laboratory of Pneumology, Dept of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wim Janssens
Laboratory of Pneumology, Dept of Chronic Diseases, Metabolism and Aging (CHROMETA), KU Leuven, Leuven, BelgiumDept of Respiratory Diseases, University Hospitals Leuven, Leuven, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Wim Janssens
  • For correspondence: wim.janssens@uzleuven.be
  • Article
  • Figures & Data
  • Info & Metrics
  • PDF
Loading

Abstract

The pathophysiological processes underlying bronchiectasis in chronic obstructive pulmonary disease (COPD) are not understood. In COPD, both small and large airways are progressively lost. It is currently not known to what extent the different airway generations of patients with COPD and bronchiectasis are involved.

COPD explant lungs with bronchiectasis were compared to COPD explant lungs without bronchiectasis and unused donor lungs as controls. In order to investigate all airway generations, a multimodal imaging approach using different resolutions was conducted. Per group, five lungs were frozen (n=15) and underwent computed tomography (CT) imaging for large airway evaluation, with four tissue cores per lung imaged for measurements of the terminal bronchioles. Two additional lungs per group (n=6) were air-dried for lobar microCT images that allow airway segmentation and three-dimensional quantification of the complete airway tree.

COPD lungs with bronchiectasis had significantly more airways compared to COPD lungs without bronchiectasis (p<0.001), with large airway numbers similar to control lungs. This difference was present in both upper and lower lobes. Lack of tapering was present (p=0.010) and larger diameters were demonstrated in lower lobes with bronchiectasis (p=0.010). MicroCT analysis of tissue cores showed similar reductions of tissue percentage, surface density and number of terminal bronchioles in both COPD groups compared to control lungs.

Although terminal bronchioles were equally reduced in COPD lungs with and without bronchiectasis, significantly more large and small airways were found in COPD lungs with bronchiectasis.

Abstract

Although terminal bronchioles are equally reduced in COPD lungs with and without bronchiectasis, significantly more large and small airways are found in COPD lungs with bronchiectasis http://bit.ly/2YJ5kKs

Footnotes

  • This article has supplementary material available from erj.ersjournals.com

  • Support statement: This study was supported by the KU Leuven Research Fund (C24/15/030) and the AstraZeneca Chair in respiratory pathophysiology KU Leuven. The Ghent University Special Research Fund (BOF-UGent) is acknowledged for the financial support to the Centre of Expertise UGCT (BOF.EXP.2017.000007). Funding information for this article has been deposited with the Crossref Funder Registry.

  • Conflict of interest: S. Everaerts reports grants from FWO, Flemish research fund (11V9417N), during the conduct of the study.

  • Conflict of interest: J.E. McDonough has nothing to disclose.

  • Conflict of interest: S.E. Verleden has nothing to disclose.

  • Conflict of interest: I. Josipovic has nothing to disclose.

  • Conflict of interest: M. Boone has nothing to disclose.

  • Conflict of interest: A. Dubbeldam has nothing to disclose.

  • Conflict of interest: C. Mathyssen has nothing to disclose.

  • Conflict of interest: J. Serré has nothing to disclose.

  • Conflict of interest: L.J. Dupont has nothing to disclose.

  • Conflict of interest: G. Gayan-Ramirez has nothing to disclose.

  • Conflict of interest: J. Verschakelen has nothing to disclose.

  • Conflict of interest: J.C. Hogg has nothing to disclose.

  • Conflict of interest: G.M. Verleden has nothing to disclose.

  • Conflict of interest: B.M. Vanaudenaerde has nothing to disclose.

  • Conflict of interest: W. Janssens reports grants from AstraZeneca, Chiesi and Boehringer Ingelheim, outside the submitted work.

  • Received November 13, 2018.
  • Accepted August 3, 2019.
  • Copyright ©ERS 2019
https://www.ersjournals.com/user-licence
View Full Text

INDIVIDUALS

Log in using your username and password

– ERS members: log in with your myERS username and password.
– Other users: log in with the credentials you created when you registered.
Forgot your user name or password?
Forgot your username or password?

LIBRARY USERS

Log in through your institution

If your library has a subscription, you may already be logged in via your IP address. Otherwise you may be able to log in via one of the following routes.
You may be able to gain access using your login credentials for your institution. Contact your library if you do not have a username and password.
If your organization uses OpenAthens, you can log in using your OpenAthens username and password. To check if your institution is supported, please see this list. Contact your library for more details.
If you think you should have access, please contact your librarian or email journals@ersnet.org

Purchase access

You may purchase access to this article. This will require you to create an account if you don't already have one.

CONTACT US

If you have any questions about the ERS publications website, please contact journals@ersnet.org

PreviousNext
Back to top
View this article with LENS
Vol 54 Issue 5 Table of Contents
European Respiratory Journal: 54 (5)
  • Table of Contents
  • Index by author
Email

Thank you for your interest in spreading the word on European Respiratory Society .

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Airway morphometry in COPD with bronchiectasis: a view on all airway generations
(Your Name) has sent you a message from European Respiratory Society
(Your Name) thought you would like to see the European Respiratory Society web site.
Print
Alerts
Sign In to Email Alerts with your Email Address
Citation Tools
Airway morphometry in COPD with bronchiectasis: a view on all airway generations
Stephanie Everaerts, John E. McDonough, Stijn E. Verleden, Iván Josipovic, Matthieu Boone, Adriana Dubbeldam, Carolien Mathyssen, Jef Serré, Lieven J. Dupont, Ghislaine Gayan-Ramirez, Johny Verschakelen, James C. Hogg, Geert M. Verleden, Bart M. Vanaudenaerde, Wim Janssens
European Respiratory Journal Nov 2019, 54 (5) 1802166; DOI: 10.1183/13993003.02166-2018

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Airway morphometry in COPD with bronchiectasis: a view on all airway generations
Stephanie Everaerts, John E. McDonough, Stijn E. Verleden, Iván Josipovic, Matthieu Boone, Adriana Dubbeldam, Carolien Mathyssen, Jef Serré, Lieven J. Dupont, Ghislaine Gayan-Ramirez, Johny Verschakelen, James C. Hogg, Geert M. Verleden, Bart M. Vanaudenaerde, Wim Janssens
European Respiratory Journal Nov 2019, 54 (5) 1802166; DOI: 10.1183/13993003.02166-2018
del.icio.us logo Digg logo Reddit logo Technorati logo Twitter logo CiteULike logo Connotea logo Facebook logo Google logo Mendeley logo
Full Text (PDF)

Jump To

  • Article
    • Abstract
    • Abstract
    • Introduction
    • Materials and methods
    • Results
    • Discussion
    • Supplementary material
    • Shareable PDF
    • Acknowledgements
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • PDF

Subjects

  • COPD and smoking
  • CF and non-CF bronchiectasis
  • Tweet Widget
  • Facebook Like
  • Google Plus One

More in this TOC Section

  • Pharmacogenomics of ICS and lung function decline in COPD
  • Reference genes determination for real-time PCR using induced sputum samples
  • Detailed history and test results for diagnosis of asthma in children
Show more Original Articles

Related Articles

Navigate

  • Home
  • Current issue
  • Archive

About the ERJ

  • Journal information
  • Editorial board
  • Reviewers
  • CME
  • Press
  • Permissions and reprints
  • Advertising

The European Respiratory Society

  • Society home
  • myERS
  • Privacy policy
  • Accessibility

ERS publications

  • European Respiratory Journal
  • ERJ Open Research
  • European Respiratory Review
  • Breathe
  • ERS books online
  • ERS Bookshop

Help

  • Feedback

For authors

  • Instructions for authors
  • Submit a manuscript
  • ERS author centre

For readers

  • Alerts
  • Subjects
  • Collections
  • Podcasts
  • RSS

Subscriptions

  • Accessing the ERS publications

Contact us

European Respiratory Society
442 Glossop Road
Sheffield S10 2PX
United Kingdom
Tel: +44 114 2672860
Email: journals@ersnet.org

ISSN

Print ISSN:  0903-1936
Online ISSN: 1399-3003

Copyright © 2019 by the European Respiratory Society