Factors associated with early progression# | | | | | |
Contact characteristics | | | | | |
Sex | | | | | |
Female | 9132 | 62 | Ref | Ref | |
Male | 8349 | 78 | 1.38 (0.98–1.93) | 1.23 (0.88–1.73) | 0.227 |
Not stated | 119 | 0 | NA | NA | |
Age | | | | | |
0–4 years | 1153 | 44 | 11.78 (7.75–17.84) | 7.79 (4.80–12.62) | <0.001* |
5–14 years | 1951 | 49 | 7.75 (5.17–11.61) | 5.23 (3.39–8.07) | <0.001* |
15 years and above | 14 496 | 47 | Ref | Ref | |
Type of contact | | | | | |
Close contacts | 7871 | 123 | 8.94 (5.54–15.40) | 5.73 (3.39–9.69) | <0.001* |
Other contacts | 9729 | 17 | Ref | Ref | |
Country of birth | | | | | |
Low burden | 11 824 | 100 | Ref | Ref | |
High burden | 5090 | 40 | 0.73 (0.52–1.02) | 1.76 (1.11–2.81) | 0.017* |
Not stated | 686 | 0 | NA | NA | |
Tuberculin skin test | | | | | |
Negative | 12 222 | 11 | Ref | Not included | |
Positive | 3112 | 101 | 36.06 (20.24–71.31)* | | |
Not performed | 2266 | 28 | 13.73 (7.02–28.83)* | | |
BCG | | | | | |
No | 4995 | 69 | Ref | | |
Yes | 7505 | 37 | 0.36 (0.24–0.53) | 0.47 (0.29–0.77) | 0.002* |
Not stated/unknown | 5100 | 34 | 0.48 (0.32–0.73) | 0.79 (0.50–1.23) | 0.288 |
Index characteristics | | | | | |
Sex | | | | | |
Male | 9439 | 75 | Ref | | |
Female | 8161 | 65 | 1.00 (0.72–1.40) | 1.14 (0.80–1.62) | 0.485 |
Age | | | | | |
1–14 years | 521 | 10 | 3.76 (1.76–7.31) | 0.20 (0.03–1.45) | 0.110 |
15–24 years | 7249 | 37 | Ref | | |
25–44 years | 5181 | 73 | 2.76 (1.87–4.15) | 1.04 (0.69–1.55) | 0.860 |
45–64 years | 1713 | 17 | 1.94 (1.06–3.40) | 1.57 (0.91–2.71) | 0.101 |
65 years and above | 2936 | 3 | 0.20 (0.05–0.55) | 0.60 (0.32–1.13) | 0.111 |
Country of birth | | | | | |
High burden | 8897 | 77 | Ref | Ref | |
Low burden | 8703 | 77 | 0.84 (0.60–1.17) | 1.15 (0.81–1.63) | 0.446 |
Method of case finding | | | | | |
Clinical presentation | 16 628 | 132 | Ref | Ref | |
Other methods | 972 | 8 | 1.04 (0.46–1.99) | 1.71 (0.91–3.21) | 0.096 |
Site of TB | | | | | |
Pulmonary | 14 655 | 122 | Ref | Ref | |
Pulmonary plus other site | 2945 | 18 | 0.73 (0.43–1.17) | 1.20 (0.76–1.90) | 0.435 |
Type of TB | | | | | |
New | 16 584 | 130 | Ref | Ref | |
Recurrent | 774 | 10 | 1.65 (0.81–2.99) | 2.68 (1.42–5.06) | 0.002* |
Unknown | 242 | 0 | NA | NA | |
Chest radiography finding | | | | | |
Abnormal, no cavity | 10 172 | 79 | Ref | Ref | |
Abnormal, cavity | 5959 | 55 | 1.19 (0.84–1.68) | 1.20 (0.82–1.75) | 0.347 |
Abnormal, no details | 265 | 1 | 0.49 (0.07–3.51) | 0.30 (0.04–2.21) | 0.236 |
Normal | 339 | 2 | 0.76 (0.19–3.10) | 0.72 (0.17–3.04) | 0.655 |
Not stated/done | 865 | 3 | 0.45 (0.14–1.42) | 0.42 (0.13–1.36) | 0.146 |
Sputum smear | | | | | |
Yes | 2212 | 15 | Ref | Ref | |
No | 3609 | 31 | 0.85 (0.49–1.47) | 0.88 (0.47–1.62) | 0.677 |
Not done/recorded | 11 779 | 94 | 1.08 (0.72–1.62) | 1.29 (0.83–2.01) | 0.264 |
Factors associated with late reactivation¶ | | | | | |
Contact characteristics | | | | | |
Sex | | | | | |
Female | 7585 | 31 | Ref | Ref | |
Male | 6733 | 35 | 1.26 (0.77–2.06) | 1.20 (0.74–1.96) | 0.460 |
Not stated | 112 | 0 | NA | NA | |
Type of contact | | | | | |
Close contacts | 5785 | 50 | 4.43 (2.49–7.86) | 3.25 (1.81–5.82) | <0.001* |
Other contacts | 8645 | 16 | Ref | | |
Country of birth | | | | | |
Low burden | 9246 | 23 | Ref | Ref | |
High burden | 4602 | 43 | 3.73 (2.23–6.24) | 2.17 (1.26–3.75) | 0.005* |
Not stated | 582 | 0 | NA | NA | |
Tuberculin skin test | | | | | |
Negative | 9629 | 16 | Ref | Not included | |
Positive | 2729 | 35 | 6.94 (3.78–2.74)* | | |
Not performed | 2072 | 15 | 5.06 (2.45–0.43)* | | |
BCG | | | | | |
No | 3374 | 3 | Ref | Ref | |
Yes | 6794 | 46 | 7.89 (2.43–25.65) | 4.54 (1.35–15.28) | 0.014* |
Not stated | 4262 | 17 | 4.48 (1.30–15.42) | 3.52 (1.01–12.26) | 0.048* |
Index characteristics | | | | | |
Sex | | | | | |
Male | 7632 | 24 | Ref | Ref | |
Female | 6798 | 42 | 2.08 (1.14–3.82) | 0.55 (0.29–1.03) | 0.06 |
Country of birth | | | | | |
High burden | 7672 | 36 | Ref | Ref | |
Low burden | 6758 | 30 | 1.39 (0.76–2.54) | 1.43 (0.78–2.60) | 0.24 |
Method of case finding | | | | | |
Clinical presentation | 13 533 | 64 | Ref | Ref | |
Other methods | 897 | 2 | 0.50 (0.11–2.27) | 0.42 (0.09–1.89) | 0.26 |
Type of TB | | | | | |
New case | 13 553 | 64 | Ref | Ref | |
Recurrent | 704 | 2 | 0.72 (0.14–3.69) | 0.82 (0.16–4.11) | 0.81 |
Unknown | 173 | 0 | NA | NA | |
Chest radiography finding | | | | | |
Abnormal, no cavity | 8025 | 40 | Ref | Ref | |
Abnormal, cavity | 5285 | 25 | 0.92 (0.56–1.52) | 0.62 (0.16–4.11) | 0.17 |
Abnormal, no details | 185 | 0 | NA | NA | |
Normal | 291 | 0 | NA | NA | |
Not done/stated | 644 | 1 | 0.27 (0.04–1.99) | 0.40 (0.04–3.89) | 0.43 |