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Transbronchial cryobiopsy for diffuse parenchymal lung disease: 30- and 90-day mortality

Jasleen Pannu, Lance J. Roller, Fabien Maldonado, Robert J. Lentz, Heidi Chen, Otis B. Rickman
European Respiratory Journal 2019 54: 1900337; DOI: 10.1183/13993003.00337-2019
Jasleen Pannu
1Division of Pulmonary, Critical Care, and Sleep Medicine, Ohio State University Medical Center, Columbus, OH, USA
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  • For correspondence: jasleen.Pannu@osumc.edu
Lance J. Roller
2Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
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Fabien Maldonado
2Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
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Robert J. Lentz
2Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
3Dept of Veterans Affairs Medical Center, Nashville, TN, USA
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Heidi Chen
4Dept of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA
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Otis B. Rickman
2Division of Allergy, Pulmonary and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, USA
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Extract

Surgical lung biopsy (SLB) in diffuse parenchymal lung disease (DPLD) has been associated with significant in-hospital mortality (16% for non-elective patients, 1.7% for elective patients, overall 6.4%) [1, 2]. Overall 30-day mortality from SLB is reported at 1.5–4.5% from case series and 2.4% from a large European database [3]. Transbronchial cryobiopsy (TBC) has been proposed as a safer alternative to SLB for diagnosis of DPLD [4]. Existing studies on TBC report immediate procedural complications, but data on mortality at 30 and 90 days is sparse [2].

Abstract

This study suggests 30- and 90-day mortality after transbronchial cryobiopsy is higher than reported, confirming concerns raised about safety in advanced diffuse lung disease. Keen attention towards patient selection and procedural planning is warranted. http://bit.ly/2ySoZNq

Footnotes

  • Conflict of interest: J. Pannu has nothing to disclose.

  • Conflict of interest: L.J. Roller has nothing to disclose.

  • Conflict of interest: F. Maldonado reports grants from ERBE research funding, outside the submitted work.

  • Conflict of interest: R.J. Lentz has nothing to disclose.

  • Conflict of interest: H. Chen has nothing to disclose.

  • Conflict of interest: O.B. Rickman has nothing to disclose.

  • Received February 18, 2019.
  • Accepted June 25, 2019.
  • Copyright ©ERS 2019
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Transbronchial cryobiopsy for diffuse parenchymal lung disease: 30- and 90-day mortality
Jasleen Pannu, Lance J. Roller, Fabien Maldonado, Robert J. Lentz, Heidi Chen, Otis B. Rickman
European Respiratory Journal Oct 2019, 54 (4) 1900337; DOI: 10.1183/13993003.00337-2019

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Transbronchial cryobiopsy for diffuse parenchymal lung disease: 30- and 90-day mortality
Jasleen Pannu, Lance J. Roller, Fabien Maldonado, Robert J. Lentz, Heidi Chen, Otis B. Rickman
European Respiratory Journal Oct 2019, 54 (4) 1900337; DOI: 10.1183/13993003.00337-2019
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