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Table of Contents

01 October 2019; volume 54, issue 4

Editorials

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    Doubts about the adverse effects of air pollution on asthma?
    Isabella Annesi-Maesano, Francesco Forastiere
    European Respiratory Journal 54 (4) 1901900; DOI: 10.1183/13993003.01900-2019 Published 31 October 2019
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    Identifying the at risk smokers: who goes on to get COPD?
    Arina Madan, Alice M. Turner
    European Respiratory Journal 54 (4) 1901613; DOI: 10.1183/13993003.01613-2019 Published 31 October 2019
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    Screening migrants for tuberculosis and latent TB infection: the reward will come later
    Jean-Pierre Zellweger
    European Respiratory Journal 54 (4) 1901719; DOI: 10.1183/13993003.01719-2019 Published 31 October 2019
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    Why are people with asthma more susceptible to influenza?
    Peter A.B. Wark
    European Respiratory Journal 54 (4) 1901748; DOI: 10.1183/13993003.01748-2019 Published 24 October 2019
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    The future of drug-resistant tuberculosis treatment: learning from the past and the 2019 World Health Organization consolidated guidelines
    José A. Caminero, Alberto L. García-Basteiro, Adrián Rendon, Alberto Piubello, Emanuele Pontali, Giovanni Battista Migliori
    European Respiratory Journal 54 (4) 1901272; DOI: 10.1183/13993003.01272-2019 Published 10 October 2019
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    Is gender inequity in ventilator management a “women's issue”?
    Marcus J. Schultz, Christian Karagiannidis
    European Respiratory Journal 54 (4) 1901588; DOI: 10.1183/13993003.01588-2019 Published 17 October 2019
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    Is adding fluoroquinolones to regimens for treating isoniazid-resistant tuberculosis necessary?
    Roland Diel, Neil W. Schluger
    European Respiratory Journal 54 (4) 1901494; DOI: 10.1183/13993003.01494-2019 Published 10 October 2019
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    Mitochondrial dysfunction in macrophages: a key to defective bacterial phagocytosis in COPD
    Mathew Suji Eapen, Pawan Sharma, Sukhwinder Singh Sohal
    European Respiratory Journal 54 (4) 1901641; DOI: 10.1183/13993003.01641-2019 Published 10 October 2019
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    Looking backwards: is it time to assess veno-atrial interactions in pulmonary arterial hypertension?
    Steven Pugliese, Rebecca R. Vanderpool
    European Respiratory Journal 54 (4) 1901598; DOI: 10.1183/13993003.01598-2019 Published 17 October 2019
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    Translation of in vitro findings to patients with asthma: a timely and compelling challenge
    Pieter S. Hiemstra, Peter J. Sterk
    European Respiratory Journal 54 (4) 1901759; DOI: 10.1183/13993003.01759-2019 Published 10 October 2019

Original Articles

  • Asthma and epidemiology

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      Outdoor air pollution and the burden of childhood asthma across Europe
      Haneen Khreis, Marta Cirach, Natalie Mueller, Kees de Hoogh, Gerard Hoek, Mark J. Nieuwenhuijsen, David Rojas-Rueda
      European Respiratory Journal 54 (4) 1802194; DOI: 10.1183/13993003.02194-2018 Published 31 October 2019
  • Asthma and genetics

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      The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D
      Rachel S. Kelly, Bo L. Chawes, Feng Guo, Li Zhang, Kevin Blighe, Augusto A. Litonjua, Benjamin A. Raby, Bruce D. Levy, Daniela Rago, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Xiaobo Zhou, Jessica A. Lasky-Su, Scott T. Weiss
      European Respiratory Journal 54 (4) 1900761; DOI: 10.1183/13993003.00761-2019 Published 24 October 2019
  • Interstitial lung disease

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      Epidemiology and health outcomes of sarcoidosis in a universal healthcare population: a cohort study
      Lee M. Fidler, Meyer Balter, Jolene H. Fisher, Teresa To, Matthew B. Stanbrook, Andrea Gershon
      European Respiratory Journal 54 (4) 1900444; DOI: 10.1183/13993003.00444-2019 Published 24 October 2019
  • Asthma

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      Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza
      Akhilesh Jha, Jake Dunning, Tanushree Tunstall, Ryan S. Thwaites, Long T. Hoang, The MOSAIC Investigators, Onn Min Kon, Maria C. Zambon, Trevor T. Hansel, Peter J. Openshaw
      European Respiratory Journal 54 (4) 1900949; DOI: 10.1183/13993003.00949-2019 Published 24 October 2019
  • Acute lung injury and critical care

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      Demographics, management and outcome of females and males with acute respiratory distress syndrome in the LUNG SAFE prospective cohort study
      Bairbre A. McNicholas, Fabiana Madotto, Tài Pham, Emanuele Rezoagli, Claire H. Masterson, Shahd Horie, Giacomo Bellani, Laurent Brochard, John G. Laffey on behalf of the LUNG SAFE Investigators and the ESICM Trials Group
      European Respiratory Journal 54 (4) 1900609; DOI: 10.1183/13993003.00609-2019 Published 17 October 2019
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      Increase in circulating ACE-positive endothelial microparticles during acute lung injury
      Yusuke Takei, Mitsuhiro Yamada, Koji Saito, Yoshinobu Kameyama, Hisatoshi Sugiura, Tomonori Makiguchi, Naoya Fujino, Akira Koarai, Hiroaki Toyama, Kazutomo Saito, Yutaka Ejima, Yu Kawazoe, Daisuke Kudo, Shigeki Kushimoto, Masanori Yamauchi, Masakazu Ichinose
      European Respiratory Journal 54 (4) 1801188; DOI: 10.1183/13993003.01188-2018 Published 17 October 2019
  • Lung structure and function

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      Age at menopause and lung function: a Mendelian randomisation study
      Diana A. van der Plaat, Miguel Pereira, Giancarlo Pesce, James F. Potts, André F.S. Amaral, Shyamali C. Dharmage, Judith M. Garcia-Aymerich, John R. Thompson, Francisco Gómez Real, Deborah L. Jarvis, Cosetta Minelli, Bénédicte Leynaert on behalf of the ALEC project
      European Respiratory Journal 54 (4) 1802421; DOI: 10.1183/13993003.02421-2018 Published 17 October 2019
  • Lung cancer

    • Open Access
      Sequential screening for lung cancer in a high-risk group: randomised controlled trial
      Stephen G. Spiro, Pallav L. Shah, Robert C. Rintoul, Jeremy George, Samuel Janes, Matthew Callister, Marco Novelli, Penny Shaw, Gabrijela Kocjan, Chris Griffiths, Mary Falzon, Richard Booton, Nicholas Magee, Michael Peake, Paul Dhillon, Kishore Sridharan, Andrew G. Nicholson, Simon Padley, Magali N. Taylor, Asia Ahmed, Jack Allen, Yenting Ngai, Nyasha Chinyanganya, Victoria Ashford-Turner, Sarah Lewis, Dahmane Oukrif, Pamela Rabbitts, Nicholas Counsell, Allan Hackshaw
      European Respiratory Journal 54 (4) 1900581; DOI: 10.1183/13993003.00581-2019 Published 17 October 2019
  • Tuberculosis

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      Tuberculosis among asylum seekers in Milan, Italy: epidemiological analysis and evaluation of interventions
      Simone Villa, Luigi Ruffo Codecasa, Marino Faccini, Mirella Maria Pontello, Maurizio Ferrarese, Paola Francesca Castellotti, Sabrina Senatore, Anna Lamberti, Ester Mazzola, Carlo Federico Perno, Daniela Campisi, Matteo Saporiti, Mario Carlo Raviglione
      European Respiratory Journal 54 (4) 1900896; DOI: 10.1183/13993003.00896-2019 Published 31 October 2019
    • Open Access
      Fluoroquinolones and isoniazid-resistant tuberculosis: implications for the 2018 WHO guidance
      Helen R. Stagg, Graham H. Bothamley, Jennifer A. Davidson, Heinke Kunst, Maeve K. Lalor, Marc C. Lipman, Miranda G. Loutet, Stefan Lozewicz, Tehreem Mohiyuddin, Aula Abbara, Eliza Alexander, Helen Booth, Dean D. Creer, Ross J. Harris, Onn Min Kon, Michael R. Loebinger, Timothy D. McHugh, Heather J. Milburn, Paramita Palchaudhuri, Patrick P.J. Phillips, Erik Schmok, Lucy Taylor, Ibrahim Abubakar on behalf of the London INH-R TB study group
      European Respiratory Journal 54 (4) 1900982; DOI: 10.1183/13993003.00982-2019 Published 10 October 2019
  • COPD

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      Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS
      Mehrdad Arjomandi, Siyang Zeng, Igor Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Russell G. Buhr, Gerard J. Criner, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Jeffrey L. Curtis, Mark T. Dransfield, MeiLan K. Han, Nadia N. Hansel, Eric A. Hoffman, Robert J. Kaner, Richard E. Kanner, Jerry A. Krishnan, Robert Paine III, Stephen P. Peters, Stephen I. Rennard, Prescott G. Woodruff for the SPIROMICS Investigators
      European Respiratory Journal 54 (4) 1802214; DOI: 10.1183/13993003.02214-2018 Published 31 October 2019
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      Time-course of upper respiratory tract viral infection and COPD exacerbation
      Daiana Stolz, Eleni Papakonstantinou, Leticia Grize, Daniel Schilter, Werner Strobel, Renaud Louis, Christian Schindler, Hans H. Hirsch, Michael Tamm
      European Respiratory Journal 54 (4) 1900407; DOI: 10.1183/13993003.00407-2019 Published 10 October 2019
  • COPD and basic science

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      Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages
      Kylie B.R. Belchamber, Richa Singh, Craig M. Batista, Moira K. Whyte, David H. Dockrell, Iain Kilty, Matthew J. Robinson, Jadwiga A. Wedzicha, Peter J. Barnes, Louise E. Donnelly on behalf of the COPD-MAP consortium
      European Respiratory Journal 54 (4) 1802244; DOI: 10.1183/13993003.02244-2018 Published 10 October 2019
  • Pulmonary hypertension

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      Vena cava backflow and right ventricular stiffness in pulmonary arterial hypertension
      J. Tim Marcus, Berend E. Westerhof, Joanne A. Groeneveldt, Harm Jan Bogaard, Frances S. de Man, Anton Vonk Noordegraaf
      European Respiratory Journal 54 (4) 1900625; DOI: 10.1183/13993003.00625-2019 Published 17 October 2019
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      Efficacy and safety of ralinepag, a novel oral IP agonist, in PAH patients on mono or dual background therapy: results from a phase 2 randomised, parallel group, placebo-controlled trial
      Fernando Torres, Harrison Farber, Arsen Ristic, Vallerie McLaughlin, John Adams, Jinkun Zhang, Preston Klassen, William Shanahan, John Grundy, Ines Hoffmann, Christopher Cabell, Pilar Escribano Subías, Namita Sood, Anne Keogh, Gwyn D'Souza, Lewis Rubin
      European Respiratory Journal 54 (4) 1901030; DOI: 10.1183/13993003.01030-2019 Published 10 October 2019
  • Pulmonary hypertension and basic science

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      CCR2/CCR5-mediated macrophage–smooth muscle cell crosstalk in pulmonary hypertension
      Shariq Abid, Elisabeth Marcos, Aurélien Parpaleix, Valérie Amsellem, Marielle Breau, Amal Houssaini, Nora Vienney, Marine Lefevre, Genevieve Derumeaux, Steven Evans, Cedric Hubeau, Marion Delcroix, Rozenn Quarck, Serge Adnot, Larissa Lipskaia
      European Respiratory Journal 54 (4) 1802308; DOI: 10.1183/13993003.02308-2018 Published 10 October 2019

Perspective

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    In vivo observations provide insight into roles of eosinophils and epithelial cells in asthma
    Carl Persson
    European Respiratory Journal 54 (4) 1900470; DOI: 10.1183/13993003.00470-2019 Published 10 October 2019

Review

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    The emerging role of mast cell proteases in asthma
    Gunnar Pejler
    European Respiratory Journal 54 (4) 1900685; DOI: 10.1183/13993003.00685-2019 Published 31 October 2019

Agora

  • Research letters

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      Pectus excavatum is associated with sleep-related breathing disorders in children
      Hiroo Wada, Manami Kimura, Ryutaro Shirahama, Ai Ikeda, David Gozal, Takeshi Tanigawa
      European Respiratory Journal 54 (4) 1900524; DOI: 10.1183/13993003.00524-2019 Published 31 October 2019
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      Epstein–Barr virus in pleural effusions: protagonist or pretender?
      David T. Arnold, Tim Suri, Fergus Hamilton, Anna Morley, Andrew Medford, Ian B. Vipond, Peter Muir, Nick A. Maskell
      European Respiratory Journal 54 (4) 1900825; DOI: 10.1183/13993003.00825-2019 Published 31 October 2019
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      Prevalence of pulmonary hypertension in pulmonary sarcoidosis: the first large European prospective study
      Marloes P. Huitema, Annelies L.M. Bakker, Johannes J. Mager, Benno J.W.M. Rensing, Fokko Smits, Repke J. Snijder, Jan C. Grutters, Marco C. Post
      European Respiratory Journal 54 (4) 1900897; DOI: 10.1183/13993003.00897-2019 Published 31 October 2019
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      Transbronchial cryobiopsy for diffuse parenchymal lung disease: 30- and 90-day mortality
      Jasleen Pannu, Lance J. Roller, Fabien Maldonado, Robert J. Lentz, Heidi Chen, Otis B. Rickman
      European Respiratory Journal 54 (4) 1900337; DOI: 10.1183/13993003.00337-2019 Published 24 October 2019
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      Blood eosinophil counts in COPD patients compared to controls
      Umme Kolsum, Thomas Southworth, Natalie Jackson, Dave Singh
      European Respiratory Journal 54 (4) 1900633; DOI: 10.1183/13993003.00633-2019 Published 24 October 2019
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      Time trends in diagnostic testing for primary ciliary dyskinesia in Europe
      Florian S. Halbeisen, Amelia Shoemark, Angelo Barbato, Mieke Boon, Siobhan Carr, Suzanne Crowley, Rob Hirst, Bulent Karadag, Cordula Koerner-Rettberg, Michael R. Loebinger, Jane S. Lucas, Bernard Maitre, Henryk Mazurek, Uğur Özçelik, Vendula Martinů, Nicolaus Schwerk, Guillaume Thouvenin, Stefan A. Tschanz, Panayiotis Yiallouros, Myrofora Goutaki, Claudia E. Kuehni
      European Respiratory Journal 54 (4) 1900528; DOI: 10.1183/13993003.00528-2019 Published 24 October 2019
    • Open Access
      Circadian rhythm of exhaled biomarkers in health and asthma
      Maxim Wilkinson, Robert Maidstone, Andrew Loudon, John Blaikley, Iain R. White, Dave Singh, David W. Ray, Royston Goodacre, Stephen J. Fowler, Hannah J. Durrington
      European Respiratory Journal 54 (4) 1901068; DOI: 10.1183/13993003.01068-2019 Published 17 October 2019
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      Tuberculosis following renal transplantation in England, Wales and Northern Ireland: a national registry-based cohort study
      Rishi K. Gupta, Gabriel Rosenberg, Jaran Eriksen, Marc Lipman, Charlotte Jackson, Anjana Roy, Dominik Zenner, Colette Smith, Mark Harber, Colin Campbell, Ibrahim Abubakar
      European Respiratory Journal 54 (4) 1802245; DOI: 10.1183/13993003.02245-2018 Published 17 October 2019
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      Profiles of tuberculosis disease activation among contacts of patients with tuberculosis
      Yayehirad A. Melsew, Allen C. Cheng, Emma S. McBryde, Justin T. Denholm, EeLaine Tay, Romain Ragonnet, James M. Trauer
      European Respiratory Journal 54 (4) 1900353; DOI: 10.1183/13993003.00353-2019 Published 10 October 2019
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      Generalised mosaicism for TSC2 mutation in isolated lymphangioleiomyomatosis
      Barbara Ogórek, Lana Hamieh, Kathryn Lasseter, Shefali Bagwe, Tania Machado, Carmen Herranz-Ors, Aaron R. Thorner, Anwesha Nag, Peter Gulleman, Krinio Giannikou, Lisa R. Young, Miquel Àngel Pujana, Thomas N. Darling, Souheil El-Chemaly, Joel Moss, Elizabeth P. Henske, David J. Kwiatkowski
      European Respiratory Journal 54 (4) 1900938; DOI: 10.1183/13993003.00938-2019 Published 10 October 2019
  • Correspondence

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      Electrical impedance tomography for chest imaging in acute respiratory failure
      Inéz Frerichs, Zhanqi Zhao
      European Respiratory Journal 54 (4) 1901497; DOI: 10.1183/13993003.01497-2019 Published 31 October 2019
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      Electrical impedance tomography for chest imaging in acute respiratory failure
      Davide Chiumello, Giuseppe Francesco Sferrazza Papa
      European Respiratory Journal 54 (4) 1901657; DOI: 10.1183/13993003.01657-2019 Published 31 October 2019
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      On the valid publication of names of mycobacteria
      Aharon Oren, Martha E. Trujillo
      European Respiratory Journal 54 (4) 1901483; DOI: 10.1183/13993003.01483-2019 Published 24 October 2019
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      On the valid publication of names of mycobacteria
      Enrico Tortoli
      European Respiratory Journal 54 (4) 1901623; DOI: 10.1183/13993003.01623-2019 Published 24 October 2019
    • You have accessRestricted access
      Is CRP-guided antibiotic treatment a safe way to reduce antibiotic use in severe hospitalised patients with exacerbations of COPD?
      Marc Miravitlles, Carl Llor, Lars Bjerrum, Sanjay Sethi, Antonio Anzueto
      European Respiratory Journal 54 (4) 1901405; DOI: 10.1183/13993003.01405-2019 Published 17 October 2019
    • You have accessRestricted access
      Is CRP-guided antibiotic treatment a safe way to reduce antibiotic use in severe hospitalised patients with exacerbations of COPD?
      Henk-Jan Prins, Tjip S. van der Werf, Wim G. Boersma
      European Respiratory Journal 54 (4) 1901597; DOI: 10.1183/13993003.01597-2019 Published 17 October 2019
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      A transcutaneous carbon dioxide monitor is a useful tool with known caveats
      Mauro Maniscalco, Salvatore Fuschillo
      European Respiratory Journal 54 (4) 1900918; DOI: 10.1183/13993003.00918-2019 Published 10 October 2019
    • You have accessRestricted access
      Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
      Chris Ward, Zelal Jaber Kharaba
      European Respiratory Journal 54 (4) 1901376; DOI: 10.1183/13993003.01376-2019 Published 10 October 2019
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      Regarding epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
      Jeanne-Marie Perotin, Ratko Djukanovic, Donna E. Davies
      European Respiratory Journal 54 (4) 1901805; DOI: 10.1183/13993003.01805-2019 Published 10 October 2019
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      A roadmap for management of chronic thromboembolic pulmonary hypertension
      Xavier Jaïs, Philippe Brenot, David Montani, Elie Fadel, Marc Humbert, Gérald Simonneau
      European Respiratory Journal 54 (4) 1901295; DOI: 10.1183/13993003.01295-2019 Published 24 October 2019
    • You have accessRestricted access
      Balloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension: is Europe behind?
      Irene M. Lang, Hiromi Matsubara
      European Respiratory Journal 54 (4) 1901639; DOI: 10.1183/13993003.01639-2019 Published 24 October 2019

Author correction

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    “Balloon pulmonary angioplasty for the treatment of chronic thromboembolic pulmonary hypertension: is Europe behind?” Irene M. Lang and Hiromi Matsubara. Eur Respir J 2019; 53: 1900843.
    European Respiratory Journal 54 (4) 1950843; DOI: 10.1183/13993003.50843-2019 Published 24 October 2019
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European Respiratory Journal: 54 (4)
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