Table of Contents

Original Articles

• Asthma and epidemiology

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    Outdoor air pollution and the burden of childhood asthma across Europe

    Haneen Khreis, Marta Cirach, Natalie Mueller, Kees de Hoogh, Gerard Hoek, Mark J. Nieuwenhuijsen, David Rojas-Rueda

    European Respiratory Journal 54 (4) 1802194; DOI: 10.1183/13993003.02194-2018 Published 31 October 2019

• Asthma and genetics

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    The role of the 17q21 genotype in the prevention of early childhood asthma and recurrent wheeze by vitamin D

    Rachel S. Kelly, Bo L. Chawes, Feng Guo, Li Zhang, Kevin Blighe, Augusto A. Litonjua, Benjamin A. Raby, Bruce D. Levy, Daniela Rago, Jakob Stokholm, Klaus Bønnelykke, Hans Bisgaard, Xiaobo Zhou, Jessica A. Lasky-Su, Scott T. Weiss

    European Respiratory Journal 54 (4) 1900761; DOI: 10.1183/13993003.00761-2019 Published 24 October 2019

• Interstitial lung disease

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    Epidemiology and health outcomes of sarcoidosis in a universal healthcare population: a cohort study

    Lee M. Fidler, Meyer Balter, Jolene H. Fisher, Teresa To, Matthew B. Stanbrook, Andrea Gershon

    European Respiratory Journal 54 (4) 1900444; DOI: 10.1183/13993003.00444-2019 Published 24 October 2019

• Asthma

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    Patterns of systemic and local inflammation in patients with asthma hospitalised with influenza

    Akhilesh Jha, Jake Dunning, Tanushree Tunstall, Ryan S. Thwaites, Long T. Hoang, Onn Min Kon, Maria C. Zambon, Trevor T. Hansel, Peter J. Openshaw

    European Respiratory Journal 54 (4) 1900949; DOI: 10.1183/13993003.00949-2019 Published 24 October 2019

• Acute lung injury and critical care

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    Demographics, management and outcome of females and males with acute respiratory distress syndrome in the LUNG SAFE prospective cohort study

    Bairbre A. McNicholas, Fabiana Madotto, Tài Pham, Emanuele Rezoagli, Claire H. Masterson, Shahd Horie, Giacomo Bellani, Laurent Brochard, John G. Laffey on behalf of the LUNG SAFE Investigators and the ESICM Trials Group

    European Respiratory Journal 54 (4) 1900609; DOI: 10.1183/13993003.00609-2019 Published 17 October 2019
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    Increase in circulating ACE-positive endothelial microparticles during acute lung injury

    Yusuke Takei, Mitsuhiro Yamada, Koji Saito, Yoshinobu Kameyama, Hisatoshi Sugiura, Tomonori Makiguchi, Naoya Fujino, Akira Koarai, Hiroaki Toyama, Kazutomo Saito, Yutaka Ejima, Yu Kawazoe, Daisuke Kudo, Shigeki Kushimoto, Masanori Yamauchi, Masakazu Ichinose

    European Respiratory Journal 54 (4) 1801188; DOI: 10.1183/13993003.01188-2018 Published 17 October 2019

• Lung structure and function

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    Age at menopause and lung function: a Mendelian randomisation study

    Diana A. van der Plaat, Miguel Pereira, Giancarlo Pesce, James F. Potts, André F.S. Amaral, Shyamali C. Dharmage, Judith M. Garcia-Aymerich, John R. Thompson, Francisco Gómez Real, Deborah L. Jarvis, Cosetta Minelli, Bénédicte Leynaert on behalf of the ALEC project

    European Respiratory Journal 54 (4) 1802421; DOI: 10.1183/13993003.02421-2018 Published 17 October 2019

• Lung cancer

  • Open Access

    Sequential screening for lung cancer in a high-risk group: randomised controlled trial

    Stephen G. Spiro, Pallav L. Shah, Robert C. Rintoul, Jeremy George, Samuel Janes, Matthew Callister, Marco Novelli, Penny Shaw, Gabrijela Kocjan, Chris Griffiths, Mary Falzon, Richard Booton, Nicholas Magee, Michael Peake, Paul Dhillon, Kishore Sridharan, Andrew G. Nicholson, Simon Padley, Magali N. Taylor, Asia Ahmed, Jack Allen, Yenting Ngai, Nyasha Chinyanganya, Victoria Ashford-Turner, Sarah Lewis, Dahmane Oukrif, Pamela Rabbitts, Nicholas Counsell, Allan Hackshaw

    European Respiratory Journal 54 (4) 1900581; DOI: 10.1183/13993003.00581-2019 Published 17 October 2019

• Tuberculosis

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    Tuberculosis among asylum seekers in Milan, Italy: epidemiological analysis and evaluation of interventions

    Simone Villa, Luigi Ruffo Codecasa, Marino Faccini, Mirella Maria Pontello, Maurizio Ferrarese, Paola Francesca Castellotti, Sabrina Senatore, Anna Lamberti, Ester Mazzola, Carlo Federico Perno, Daniela Campisi, Matteo Saporiti, Mario Carlo Raviglione

    European Respiratory Journal 54 (4) 1900896; DOI: 10.1183/13993003.00896-2019 Published 31 October 2019
  • Open Access

    Fluoroquinolones and isoniazid-resistant tuberculosis: implications for the 2018 WHO guidance

    Helen R. Stagg, Graham H. Bothamley, Jennifer A. Davidson, Heinke Kunst, Maeve K. Lalor, Marc C. Lipman, Miranda G. Loutet, Stefan Lozewicz, Tehreem Mohiyuddin, Aula Abbara, Eliza Alexander, Helen Booth, Dean D. Creer, Ross J. Harris, Onn Min Kon, Michael R. Loebinger, Timothy D. McHugh, Heather J. Milburn, Paramita Palchaudhuri, Patrick P.J. Phillips, Erik Schmok, Lucy Taylor, Ibrahim Abubakar on behalf of the London INH-R TB study group

    European Respiratory Journal 54 (4) 1900982; DOI: 10.1183/13993003.00982-2019 Published 10 October 2019

• COPD

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    Radiographic lung volumes predict progression to COPD in smokers with preserved spirometry in SPIROMICS

    Mehrdad Arjomandi, Siyang Zeng, Igor Barjaktarevic, R. Graham Barr, Eugene R. Bleecker, Russell P. Bowler, Russell G. Buhr, Gerard J. Criner, Alejandro P. Comellas, Christopher B. Cooper, David J. Couper, Jeffrey L. Curtis, Mark T. Dransfield, MeiLan K. Han, Nadia N. Hansel, Eric A. Hoffman, Robert J. Kaner, Richard E. Kanner, Jerry A. Krishnan, Robert Paine III, Stephen P. Peters, Stephen I. Rennard, Prescott G. Woodruff for the SPIROMICS Investigators

    European Respiratory Journal 54 (4) 1802214; DOI: 10.1183/13993003.02214-2018 Published 31 October 2019
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    Time-course of upper respiratory tract viral infection and COPD exacerbation

    Daiana Stolz, Eleni Papakonstantinou, Leticia Grize, Daniel Schilter, Werner Strobel, Renaud Louis, Christian Schindler, Hans H. Hirsch, Michael Tamm

    European Respiratory Journal 54 (4) 1900407; DOI: 10.1183/13993003.00407-2019 Published 10 October 2019

• COPD and basic science

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    Defective bacterial phagocytosis is associated with dysfunctional mitochondria in COPD macrophages

    Kylie B.R. Belchamber, Richa Singh, Craig M. Batista, Moira K. Whyte, David H. Dockrell, Iain Kilty, Matthew J. Robinson, Jadwiga A. Wedzicha, Peter J. Barnes, Louise E. Donnelly on behalf of the COPD-MAP consortium

    European Respiratory Journal 54 (4) 1802244; DOI: 10.1183/13993003.02244-2018 Published 10 October 2019

• Pulmonary hypertension

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    Vena cava backflow and right ventricular stiffness in pulmonary arterial hypertension

    J. Tim Marcus, Berend E. Westerhof, Joanne A. Groeneveldt, Harm Jan Bogaard, Frances S. de Man, Anton Vonk Noordegraaf

    European Respiratory Journal 54 (4) 1900625; DOI: 10.1183/13993003.00625-2019 Published 17 October 2019
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    Efficacy and safety of ralinepag, a novel oral IP agonist, in PAH patients on mono or dual background therapy: results from a phase 2 randomised, parallel group, placebo-controlled trial

    Fernando Torres, Harrison Farber, Arsen Ristic, Vallerie McLaughlin, John Adams, Jinkun Zhang, Preston Klassen, William Shanahan, John Grundy, Ines Hoffmann, Christopher Cabell, Pilar Escribano Subías, Namita Sood, Anne Keogh, Gwyn D'Souza, Lewis Rubin

    European Respiratory Journal 54 (4) 1901030; DOI: 10.1183/13993003.01030-2019 Published 10 October 2019

• Pulmonary hypertension and basic science

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    CCR2/CCR5-mediated macrophage–smooth muscle cell crosstalk in pulmonary hypertension

    Shariq Abid, Elisabeth Marcos, Aurélien Parpaleix, Valérie Amsellem, Marielle Breau, Amal Houssaini, Nora Vienney, Marine Lefevre, Genevieve Derumeaux, Steven Evans, Cedric Hubeau, Marion Delcroix, Rozenn Quarck, Serge Adnot, Larissa Lipskaia

    European Respiratory Journal 54 (4) 1802308; DOI: 10.1183/13993003.02308-2018 Published 10 October 2019