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Table of Contents

01 September 2019; volume 54, issue 3

Editorials

  • You have accessRestricted access
    Respiratory physiotherapy in the bronchiectasis guidelines: is there a loud voice we are yet to hear?
    Arietta Spinou, James D. Chalmers
    European Respiratory Journal 54 (3) 1901610; DOI: 10.1183/13993003.01610-2019 Published 28 September 2019
  • You have accessRestricted access
    ERS and ATS diagnostic guidelines for primary ciliary dyskinesia: similarities and differences in approach to diagnosis
    Amelia Shoemark, Sharon Dell, Adam Shapiro, Jane S. Lucas
    European Respiratory Journal 54 (3) 1901066; DOI: 10.1183/13993003.01066-2019 Published 5 September 2019
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    The ERS fellowship portfolio: fostering excellence and diversity
    Rory E. Morty, Louise E. Donnelly, Daiana Stolz, Nicolas Roche, Tobias Welte, Kathryn A. Forrest, Christopher E. Brightling, Guy G. Brusselle
    European Respiratory Journal 54 (3) 1901503; DOI: 10.1183/13993003.01503-2019 Published 5 September 2019
  • Open Access
    The importance of real-life research in respiratory medicine: manifesto of the Respiratory Effectiveness Group
    Nicolas Roche, Antonio Anzueto, Sinthia Bosnic Anticevich, Alan Kaplan, Marc Miravitlles, Dermot Ryan, Joan B. Soriano, Omar Usmani, Nikolaos G. Papadopoulos, G. Walter Canonica on behalf of the Respiratory Effectiveness Group Collaborators
    European Respiratory Journal 54 (3) 1901511; DOI: 10.1183/13993003.01511-2019 Published 19 September 2019
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    Still dying in plain sight: missed and misclassified deaths due to tuberculosis in hospitals
    Byron William Patrick Reeve, Rosella Centis, Grant Theron
    European Respiratory Journal 54 (3) 1901578; DOI: 10.1183/13993003.01578-2019 Published 1 October 2019
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    Global tuberculosis prevention: should we start from the beginning?
    Giovanni Sotgiu, Delia Goletti, Alberto Matteelli
    European Respiratory Journal 54 (3) 1901394; DOI: 10.1183/13993003.01394-2019 Published 12 September 2019
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    Chronic respiratory symptoms but normal lung function: substantial disease burden but little evidence to inform practice
    Milo A. Puhan
    European Respiratory Journal 54 (3) 1901363; DOI: 10.1183/13993003.01363-2019 Published 19 September 2019
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    Breath biomarkers in asthma: we're getting answers, but what are the important questions?
    Stephen J. Fowler, Peter J. Sterk
    European Respiratory Journal 54 (3) 1901411; DOI: 10.1183/13993003.01411-2019 Published 29 September 2019
  • European lung corner

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      H2020 funding for respiratory research: scaling up for the prevention and treatment of lung diseases
      Constantine I. Vardavas, Christina N. Kyriakos, Esteve Fernández, Panagiotis Bamidis, Kamran Siddiqi, Niels H. Chavannes, R.M.J.J. van der Kleij, Gary Parker, Cornel Radu-Loghin, Brian Ward, Karim Berkouk
      European Respiratory Journal 54 (3) 1901417; DOI: 10.1183/13993003.01417-2019 Published 5 September 2019

ERS Official Documents

  • ERS guidelines

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      European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD
      Begum Ergan, Simon Oczkowski, Bram Rochwerg, Annalisa Carlucci, Michelle Chatwin, Enrico Clini, Mark Elliott, Jesus Gonzalez-Bermejo, Nicholas Hart, Manel Lujan, Jacek Nasilowski, Stefano Nava, Jean Louis Pepin, Lara Pisani, Jan Hendrik Storre, Peter Wijkstra, Thomy Tonia, Jeanette Boyd, Raffaele Scala, Wolfram Windisch
      European Respiratory Journal 54 (3) 1901003; DOI: 10.1183/13993003.01003-2019 Published 28 September 2019
  • ERS statement

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      ERS statement on tracheomalacia and bronchomalacia in children
      Colin Wallis, Efthymia Alexopoulou, Juan L. Antón-Pacheco, Jayesh M. Bhatt, Andrew Bush, Anne B. Chang, Anne-Marie Charatsi, Courtney Coleman, Julie Depiazzi, Konstantinos Douros, Ernst Eber, Mark Everard, Ahmed Kantar, Ian B. Masters, Fabio Midulla, Raffaella Nenna, Derek Roebuck, Deborah Snijders, Kostas Priftis
      European Respiratory Journal 54 (3) 1900382; DOI: 10.1183/13993003.00382-2019 Published 28 September 2019
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      ERS statement on chest imaging in acute respiratory failure
      Davide Chiumello, Giuseppe Francesco Sferrazza Papa, Antonio Artigas, Belaid Bouhemad, Aleksandar Grgic, Leo Heunks, Klaus Markstaller, Giulia M. Pellegrino, Lara Pisani, David Rigau, Marcus J. Schultz, Giovanni Sotgiu, Peter Spieth, Maurizio Zompatori, Paolo Navalesi
      European Respiratory Journal 54 (3) 1900435; DOI: 10.1183/13993003.00435-2019 Published 19 September 2019
  • ERS/EAACI statement

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      ERS/EAACI statement on severe exacerbations in asthma in adults: facts, priorities and key research questions
      Arnaud Bourdin, Leif Bjermer, Christopher Brightling, Guy G. Brusselle, Pascal Chanez, Kian Fan Chung, Adnan Custovic, Zuzana Diamant, Sarah Diver, Ratko Djukanovic, Dominique Hamerlijnck, Ildikó Horváth, Sebastian L. Johnston, Frank Kanniess, Nikos Papadopoulos, Alberto Papi, Richard J. Russell, Dermot Ryan, Konstantinos Samitas, Thomy Tonia, Eleftherios Zervas, Mina Gaga
      European Respiratory Journal 54 (3) 1900900; DOI: 10.1183/13993003.00900-2019 Published 28 September 2019

ESC Guidelines

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    2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS)
    Stavros V. Konstantinides, Guy Meyer, Cecilia Becattini, Héctor Bueno, Geert-Jan Geersing, Veli-Pekka Harjola, Menno V. Huisman, Marc Humbert, Catriona Sian Jennings, David Jiménez, Nils Kucher, Irene Marthe Lang, Mareike Lankeit, Roberto Lorusso, Lucia Mazzolai, Nicolas Meneveau, Fionnuala Ní Áinle, Paolo Prandoni, Piotr Pruszczyk, Marc Righini, Adam Torbicki, Eric Van Belle, José Luis Zamorano, The Task Force for the diagnosis and management of acute pulmonary embolism of the European Society of Cardiology (ESC)
    European Respiratory Journal 54 (3) 1901647; DOI: 10.1183/13993003.01647-2019 Published 9 October 2019

Original Articles

  • Pleural disease and infection

    • Open Access
      A systematic review of comorbidities and outcomes of adult patients with pleural infection
      Tamsin N. Cargill, Maged Hassan, John P. Corcoran, Elinor Harriss, Rachelle Asciak, Rachel M. Mercer, David J. McCracken, Eihab O. Bedawi, Najib M. Rahman
      European Respiratory Journal 54 (3) 1900541; DOI: 10.1183/13993003.00541-2019 Published 1 October 2019
    • You have accessRestricted access
      The microbiology of pleural infection in adults: a systematic review
      Maged Hassan, Tamsin Cargill, Elinor Harriss, Rachelle Asciak, Rachel M. Mercer, Eihab O. Bedawi, David J. McCracken, Ioannis Psallidas, John P. Corcoran, Najib M. Rahman
      European Respiratory Journal 54 (3) 1900542; DOI: 10.1183/13993003.00542-2019 Published 1 October 2019
  • Infection and lung transplantation

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      Pneumonia versus graft dysfunction as the cause of acute respiratory failure after lung transplant: a 4-year multicentre prospective study in 153 adults requiring intensive care admission
      Cristopher Mazo, Teresa Pont, Maria A. Ballesteros, Eloísa López, Luzdivina Rellán, Juan C. Robles, Jordi Rello
      European Respiratory Journal 54 (3) 1801512; DOI: 10.1183/13993003.01512-2018 Published 1 October 2019
  • Pulmonary hypertension

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      Prevention of progression of pulmonary hypertension by the Nur77 agonist 6-mercaptopurine: role of BMP signalling
      Kondababu Kurakula, Xiao-Qing Sun, Chris Happé, Denielli da Silva Goncalves Bos, Robert Szulcek, Ingrid Schalij, Karien C. Wiesmeijer, Kirsten Lodder, Ly Tu, Christophe Guignabert, Carlie J.M. de Vries, Frances S. de Man, Anton Vonk Noordegraaf, Peter ten Dijke, Marie-José Goumans, Harm Jan Bogaard
      European Respiratory Journal 54 (3) 1802400; DOI: 10.1183/13993003.02400-2018 Published 29 September 2019
  • Cough

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      Altered neural activity in brain cough suppression networks in cigarette smokers
      Ayaka Ando, Stuart B. Mazzone, Michael J. Farrell
      European Respiratory Journal 54 (3) 1900362; DOI: 10.1183/13993003.00362-2019 Published 19 September 2019
  • Tuberculosis

    • Open Access
      Unmasking the hidden tuberculosis mortality burden in a large post mortem study in Maputo Central Hospital, Mozambique
      Alberto L. Garcia-Basteiro, Juan Carlos Hurtado, Paola Castillo, Fabiola Fernandes, Mireia Navarro, Lucilia Lovane, Isaac Casas, Llorenç Quintó, Dercio Jordao, Mamudo R. Ismail, Cesaltina Lorenzoni, Carla Carrilho, Ariadna Sanz, Natalia Rakislova, Aurea Mira, Miriam J. Alvarez-Martínez, Anélsio Cossa, Frank Cobelens, Inácio Mandomando, Jordi Vila, Quique Bassat, Clara Menendez, Jaume Ordi, Miguel J. Martínez
      European Respiratory Journal 54 (3) 1900312; DOI: 10.1183/13993003.00312-2019 Published 1 October 2019
    • You have accessRestricted access
      The global prevalence of latent tuberculosis: a systematic review and meta-analysis
      Adam Cohen, Victor Dahl Mathiasen, Thomas Schön, Christian Wejse
      European Respiratory Journal 54 (3) 1900655; DOI: 10.1183/13993003.00655-2019 Published 12 September 2019
  • Lung structure and function

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      The optimisation of noninvasive ventilation in amyotrophic lateral sclerosis: a systematic review
      David O'Brien, Theocharis Stavroulakis, Susan Baxter, Paul Norman, Stephen Bianchi, Mark Elliott, Maxine Johnson, Mark Clowes, Aldara Garcia-Sánchez, Esther Hobson, Christopher McDermott
      European Respiratory Journal 54 (3) 1900261; DOI: 10.1183/13993003.00261-2019 Published 30 September 2019
    • You have accessRestricted access
      Prognostic significance of chronic respiratory symptoms in individuals with normal spirometry
      Yunus Çolak, Børge G. Nordestgaard, Jørgen Vestbo, Peter Lange, Shoaib Afzal
      European Respiratory Journal 54 (3) 1900734; DOI: 10.1183/13993003.00734-2019 Published 19 September 2019
    • You have accessRestricted access
      Radiographic pulmonary vessel volume, lung function and airways disease in the Framingham Heart Study
      Andrew J. Synn, Wenyuan Li, Raúl San José Estépar, Chunyi Zhang, George R. Washko, George T. O'Connor, Tetsuro Araki, Hiroto Hatabu, Alexander A. Bankier, Murray A. Mittleman, Mary B. Rice
      European Respiratory Journal 54 (3) 1900408; DOI: 10.1183/13993003.00408-2019 Published 12 September 2019
  • Asthma

    • You have accessRestricted access
      Exhaled volatile organic compounds in adult asthma: a systematic review
      Adnan Azim, Clair Barber, Paddy Dennison, John Riley, Peter Howarth
      European Respiratory Journal 54 (3) 1900056; DOI: 10.1183/13993003.00056-2019 Published 29 September 2019
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      Sensitisation to staphylococcal enterotoxins and asthma severity: a longitudinal study in the EGEA cohort
      Ina Sintobin, Valerie Siroux, Gabriële Holtappels, Christophe Pison, Rachel Nadif, Jean Bousquet, Claus Bachert
      European Respiratory Journal 54 (3) 1900198; DOI: 10.1183/13993003.00198-2019 Published 12 September 2019
  • Asthma and paediatrics

    • Open Access
      Educational and health outcomes of children treated for asthma: Scotland-wide record linkage study of 683 716 children
      Michael Fleming, Catherine A. Fitton, Markus F.C. Steiner, James S. McLay, David Clark, Albert King, Daniel F. Mackay, Jill P. Pell
      European Respiratory Journal 54 (3) 1802309; DOI: 10.1183/13993003.02309-2018 Published 5 September 2019
  • COPD

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      Bronchodilator reversibility in asthma and COPD: findings from three large population studies
      Christer Janson, Andrei Malinovschi, Andre F.S. Amaral, Simone Accordini, Jean Bousquet, A. Sonia Buist, Giorgio Walter Canonica, Barbro Dahlén, Judith Garcia-Aymerich, Louisa Gnatiuc, Marek L Kowalski, Jaymini Patel, Wan Tan, Kjell Torén, Torsten Zuberbier, Peter Burney, Deborah Jarvis
      European Respiratory Journal 54 (3) 1900561; DOI: 10.1183/13993003.00561-2019 Published 5 September 2019
  • COPD and epidemiology

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      Are smokers “hardening” or rather “softening”? An ecological and multilevel analysis across 28 European Union countries
      Ariadna Feliu, Esteve Fernandez, Cristina Martinez, Filippos T. Filippidis
      European Respiratory Journal 54 (3) 1900596; DOI: 10.1183/13993003.00596-2019 Published 19 September 2019
  • Basic science and COPD

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      Fibrocyte accumulation in the airway walls of COPD patients
      Isabelle Dupin, Matthieu Thumerel, Elise Maurat, Florence Coste, Edmée Eyraud, Hugues Begueret, Thomas Trian, Michel Montaudon, Roger Marthan, Pierre-Olivier Girodet, Patrick Berger
      European Respiratory Journal 54 (3) 1802173; DOI: 10.1183/13993003.02173-2018 Published 5 September 2019
  • Basic science and pulmonary hypertension

    • Open Access
      IL-1 receptor blockade skews inflammation towards Th2 in a mouse model of systemic sclerosis
      Anna Birnhuber, Slaven Crnkovic, Valentina Biasin, Leigh M. Marsh, Balazs Odler, Anita Sahu-Osen, Elvira Stacher-Priehse, Luka Brcic, Frank Schneider, Nada Cikes, Bahil Ghanim, Walter Klepetko, Winfried Graninger, Yannick Allanore, Robert Eferl, Andrea Olschewski, Horst Olschewski, Grazyna Kwapiszewska
      European Respiratory Journal 54 (3) 1900154; DOI: 10.1183/13993003.00154-2019 Published 29 September 2019
  • Cystic fibrosis

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      Development and external validation of 1- and 2-year mortality prediction models in cystic fibrosis
      Sanja Stanojevic, Jenna Sykes, Anne L. Stephenson, Shawn D. Aaron, George A. Whitmore
      European Respiratory Journal 54 (3) 1900224; DOI: 10.1183/13993003.00224-2019 Published 5 September 2019
  • Interstitial lung disease

    • Open Access
      Cardiovascular safety of nintedanib in subgroups by cardiovascular risk at baseline in the TOMORROW and INPULSIS trials
      Imre Noth, Marlies Wijsenbeek, Martin Kolb, Francesco Bonella, Lizette Moros, Daniel Wachtlin, Tamera J. Corte
      European Respiratory Journal 54 (3) 1801797; DOI: 10.1183/13993003.01797-2018 Published 30 September 2019
    • You have accessRestricted access
      Circulating adhesion molecules and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis
      Claire F. McGroder, Carrie P. Aaron, Suzette J. Bielinski, Steven M. Kawut, Russell P. Tracy, Ganesh Raghu, R. Graham Barr, David J. Lederer, Anna J. Podolanczuk
      European Respiratory Journal 54 (3) 1900295; DOI: 10.1183/13993003.00295-2019 Published 30 September 2019
    • Open Access
      King's Brief Interstitial Lung Disease questionnaire: responsiveness and minimum clinically important difference
      Claire M. Nolan, Surinder S. Birring, Matthew Maddocks, Toby M. Maher, Suhani Patel, Ruth E. Barker, Sarah E. Jones, Jessica A. Walsh, Stephanie C. Wynne, Peter M. George, William D-C. Man
      European Respiratory Journal 54 (3) 1900281; DOI: 10.1183/13993003.00281-2019 Published 5 September 2019

Review

  • Open Access
    Potential of nintedanib in treatment of progressive fibrosing interstitial lung diseases
    Lutz Wollin, Jörg H.W. Distler, Elizabeth F. Redente, David W.H. Riches, Susanne Stowasser, Rozsa Schlenker-Herceg, Toby M. Maher, Martin Kolb
    European Respiratory Journal 54 (3) 1900161; DOI: 10.1183/13993003.00161-2019 Published 19 September 2019

Agora

  • Research letters

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      Impact of radiographic screening of >34 000 asylum seeker children
      Bert A. Wolters, Onno W. Akkerman, Yvonne Aartsma, Wiel C.M. de Lange, Elisabeth H. Schölvinck, Tjip S. van der Werf, Rob van Hest
      European Respiratory Journal 54 (3) 1900579; DOI: 10.1183/13993003.00579-2019 Published 1 October 2019
    • Open Access
      Effect of pirfenidone on breathlessness in patients with idiopathic pulmonary fibrosis
      Marilyn K. Glassberg, Marlies S. Wijsenbeek, Frank Gilberg, Ute Petzinger, Klaus-Uwe Kirchgaessler, Carlo Albera
      European Respiratory Journal 54 (3) 1900399; DOI: 10.1183/13993003.00399-2019 Published 30 September 2019
    • Open Access
      Longitudinal prediction of outcome in idiopathic pulmonary fibrosis using automated CT analysis
      Joseph Jacob, Brian J. Bartholmai, Coline H.M. van Moorsel, Srinivasan Rajagopalan, Anand Devaraj, Hendrik W. van Es, Teng Moua, Frouke T. van Beek, Ryan Clay, Marcel Veltkamp, Maria Kokosi, Angelo de Lauretis, Eoin P. Judge, Teresa M. Jacob, Tobias Peikert, Ronald Karwoski, Fabien Maldonado, Elisabetta Renzoni, Toby M. Maher, Andre Altmann, Athol U. Wells
      European Respiratory Journal 54 (3) 1802341; DOI: 10.1183/13993003.02341-2018 Published 30 September 2019
    • Open Access
      Opioids for breathlessness: psychological and neural factors influencing response variability
      Sara J. Abdallah, Olivia K. Faull, Vishvarani Wanigasekera, Sarah L. Finnegan, Dennis Jensen, Kyle T.S. Pattinson
      European Respiratory Journal 54 (3) 1900275; DOI: 10.1183/13993003.00275-2019 Published 19 September 2019
    • You have accessRestricted access
      Extracorporeal membrane oxygenation for acute respiratory distress syndrome due to Pneumocystis pneumonia
      Klaus Stahl, Heiko Schenk, Benjamin Seeliger, Olaf Wiesner, Julius J. Schmidt, Johann Bauersachs, Tobias Welte, Christian Kühn, Axel Haverich, Marius M. Hoeper, Sascha David
      European Respiratory Journal 54 (3) 1900410; DOI: 10.1183/13993003.00410-2019 Published 19 September 2019
    • You have accessRestricted access
      Relationship between pollen concentrations and short-acting β2-agonist bronchodilator sales in central France: a daily time-series analysis over a 5-year period
      Denis M. Caillaud, Sylvie Martin, Claire Ségala, Bertrand Evrard, Nihade Adrouche
      European Respiratory Journal 54 (3) 1900271; DOI: 10.1183/13993003.00271-2019 Published 12 September 2019
    • You have accessRestricted access
      A simple echocardiographic estimate of right ventricular-arterial coupling to assess severity and outcome in pulmonary hypertension on chronic lung disease
      Khodr Tello, Hossein A. Ghofrani, Charlotte Heinze, Karsten Krueger, Robert Naeije, Christina Raubach, Werner Seeger, Natascha Sommer, Henning Gall, Manuel J. Richter
      European Respiratory Journal 54 (3) 1802435; DOI: 10.1183/13993003.02435-2018 Published 12 September 2019
    • You have accessRestricted access
      Reduced moxifloxacin exposure in patients with tuberculosis and diabetes
      Bart G.J. Dekkers, Mathieu S. Bolhuis, Lies ter Beek, Wiel C.M. de Lange, Tjip S. van der Werf, Jan-Willem C. Alffenaar, Onno W. Akkerman
      European Respiratory Journal 54 (3) 1900373; DOI: 10.1183/13993003.00373-2019 Published 5 September 2019
    • You have accessRestricted access
      Cumulative effect of smoking on disease burden and multimorbidity in adult-onset asthma
      Minna Tommola, Pinja Ilmarinen, Leena E. Tuomisto, Lauri Lehtimäki, Onni Niemelä, Pentti Nieminen, Hannu Kankaanranta
      European Respiratory Journal 54 (3) 1801580; DOI: 10.1183/13993003.01580-2018 Published 5 September 2019
  • Correspondence

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      Cancer-protective effects of inhaled corticosteroids in COPD are likely related to modification of epithelial activation
      Amir Soltani, Malik Q. Mahmood, David W. Reid, E. Haydn Walters
      European Respiratory Journal 54 (3) 1901088; DOI: 10.1183/13993003.01088-2019 Published 12 September 2019
    • You have accessRestricted access
      Inhaled corticosteroids and pneumonia mortality in COPD patients
      Pere Almagro, Pablo Martinez-Camblor, Joan B. Soriano
      European Respiratory Journal 54 (3) 1901035; DOI: 10.1183/13993003.01035-2019 Published 5 September 2019
    • You have accessRestricted access
      Inhaled corticosteroids and pneumonia mortality in COPD patients
      Samy Suissa
      European Respiratory Journal 54 (3) 1901276; DOI: 10.1183/13993003.01276-2019 Published 5 September 2019
    • You have accessRestricted access
      Misinterpretation of time-to-first event curves can lead to inappropriate treatment
      Benjamin Hartley, Gerard J. Criner, Mark T. Dransfield, David M.G. Halpin, MeiLan K. Han, C. Elaine Jones, Sally Kilbride, Peter Lange, David A. Lipson, David A. Lomas, Neil Martin, Fernando J. Martinez, Dave Singh, Robert A. Wise, Sally Lettis
      European Respiratory Journal 54 (3) 1900634; DOI: 10.1183/13993003.00634-2019 Published 5 September 2019
    • You have accessRestricted access
      Misinterpretation of time-to-first event curves can lead to inappropriate treatment
      Samy Suissa, Amnon Ariel
      European Respiratory Journal 54 (3) 1901275; DOI: 10.1183/13993003.01275-2019 Published 5 September 2019

Author Correction

  • You have accessRestricted access
    “Screening for lung cancer: time for large-scale screening by chest computed tomography.” Dekel Shlomi, Ronny Ben-Avi, Gingy Ronen Balmor, Amir Onn and Nir Peled. Eur Respir J 2014; 44: 217–238
    European Respiratory Journal 54 (3) 1351645; DOI: 10.1183/13993003.51645-2013 Published 12 September 2019
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European Respiratory Journal: 54 (3)
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