European Respiratory Journal: 54 (2)

01 August 2019; volume 54, issue 2

Editorials

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Specific challenge testing for occupational asthma: revised handbook
Hille Suojalehto, Katri Suuronen, Paul Cullinan

European Respiratory Journal 54 (2) 1901026; DOI: 10.1183/13993003.01026-2019 Published 15 August 2019
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Dysregulated balance of lung macrophage populations in idiopathic pulmonary fibrosis revealed by single-cell RNA seq: an unstable “ménage-à-trois”
Bernard Mari, Bruno Crestani

European Respiratory Journal 54 (2) 1901229; DOI: 10.1183/13993003.01229-2019 Published 22 August 2019
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When “B” becomes “A”: the emerging threat of influenza B virus
Lokesh Sharma, Andre Rebaza, Charles S. Dela Cruz

European Respiratory Journal 54 (2) 1901325; DOI: 10.1183/13993003.01325-2019 Published 15 August 2019
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Paediatric severe asthma: a need for novel innate molecular phenotypes
Kristina Laubhahn, Bianca Schaub

European Respiratory Journal 54 (2) 1901459; DOI: 10.1183/13993003.01459-2019 Published 29 August 2019
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Re-visiting the HLA dogma
Antoine Roux, Stijn E. Verleden

European Respiratory Journal 54 (2) 1901440; DOI: 10.1183/13993003.01440-2019 Published 29 August 2019
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Ultrasound-based elastography: “hard” to implement in the pleural effusion work-up?
José M. Porcel

European Respiratory Journal 54 (2) 1901587; DOI: 10.1183/13993003.01587-2019 Published 22 August 2019
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Dual intracavitary therapy for pleural infections: leaving reluctance behind
José M. Porcel

European Respiratory Journal 54 (2) 1901001; DOI: 10.1183/13993003.01001-2019 Published 1 August 2019
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The ever-expanding phenotypical spectrum of human TBX4 mutations: from toe to lung
Meindina G. Haarman, Wilhelmina S. Kerstjens-Frederikse, Rolf M.F. Berger

European Respiratory Journal 54 (2) 1901504; DOI: 10.1183/13993003.01504-2019 Published 22 August 2019
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Debating the new haemodynamic definition of pulmonary hypertension: much ado about nothing?
Gabor Kovacs, Horst Olschewski

European Respiratory Journal 54 (2) 1901278; DOI: 10.1183/13993003.01278-2019 Published 22 August 2019
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Are estimations of radiomic image markers dispensable due to recent deep learning findings?
Martin Obert

European Respiratory Journal 54 (2) 1901185; DOI: 10.1183/13993003.01185-2019 Published 29 August 2019

Original Articles

Basic science and interstitial lung disease
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  Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis
  Changwan Ryu, Caitlin Brandsdorfer, Taylor Adams, Buqu Hu, Dylan W. Kelleher, Madeleine Yaggi, Edward P. Manning, Anjali Walia, Benjamin Reeves, Hongyi Pan, Julia Winkler, Maksym Minasyan, Charles S. Dela Cruz, Naftali Kaminski, Mridu Gulati, Erica L. Herzog
  
  European Respiratory Journal 54 (2) 1801762; DOI: 10.1183/13993003.01762-2018 Published 29 August 2019
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  Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis
  Christina Morse, Tracy Tabib, John Sembrat, Kristina L. Buschur, Humberto Trejo Bittar, Eleanor Valenzi, Yale Jiang, Daniel J. Kass, Kevin Gibson, Wei Chen, Ana Mora, Panayiotis V. Benos, Mauricio Rojas, Robert Lafyatis
  
  European Respiratory Journal 54 (2) 1802441; DOI: 10.1183/13993003.02441-2018 Published 22 August 2019
Basic science and tuberculosis
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  IL-4 subverts mycobacterial containment in Mycobacterium tuberculosis-infected human macrophages
  Anil Pooran, Malika Davids, Andrew Nel, Aubrey Shoko, Jonathan Blackburn, Keertan Dheda
  
  European Respiratory Journal 54 (2) 1802242; DOI: 10.1183/13993003.02242-2018 Published 8 August 2019
Basic science and COPD
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  Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD
  Jane F. Chisholm, Siddharth K. Shenoy, Julie K. Shade, Victor Kim, Nirupama Putcha, Kathryn A. Carson, Robert Wise, Nadia N. Hansel, Justin S. Hanes, Jung Soo Suk, Enid Neptune
  
  European Respiratory Journal 54 (2) 1900088; DOI: 10.1183/13993003.00088-2019 Published 1 August 2019
Basic science and infection
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  Tropism of influenza B viruses in human respiratory tract explants and airway organoids
  Christine H.T. Bui, Renee W.Y. Chan, Mandy M.T. Ng, M-C. Cheung, Ka-chun Ng, Megan P.K. Chan, Louisa L.Y. Chan, Joanne H.M. Fong, J.M. Nicholls, J.S. Malik Peiris, Michael C.W. Chan
  
  European Respiratory Journal 54 (2) 1900008; DOI: 10.1183/13993003.00008-2019 Published 15 August 2019
Basic science and asthma
- Open Access
  Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids
  Prasad Nagakumar, Franz Puttur, Lisa G. Gregory, Laura Denney, Louise Fleming, Andrew Bush, Clare M. Lloyd, Sejal Saglani
  
  European Respiratory Journal 54 (2) 1801809; DOI: 10.1183/13993003.01809-2018 Published 29 August 2019
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  Neutrophilic inflammation in asthma and defective epithelial translational control
  Abilash Ravi, Saheli Chowdhury, Annemiek Dijkhuis, Peter I. Bonta, Peter J. Sterk, René Lutter
  
  European Respiratory Journal 54 (2) 1900547; DOI: 10.1183/13993003.00547-2019 Published 15 August 2019
Imaging
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  Pulmonary vascular density: comparison of findings on computed tomography imaging with histology
  Farbod N. Rahaghi, Gemma Argemí, Pietro Nardelli, David Domínguez-Fandos, Pedro Arguis, Víctor I. Peinado, James C. Ross, Samuel Y. Ash, Isaac de La Bruere, Carolyn E. Come, Alejandro A. Diaz, Marcelo Sánchez, George R. Washko, Joan Albert Barberà, Raúl San José Estépar
  
  European Respiratory Journal 54 (2) 1900370; DOI: 10.1183/13993003.00370-2019 Published 15 August 2019
Lung transplantation
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  Donor human leukocyte antigen-G single nucleotide polymorphisms are associated with post-lung transplant mortality
  Julieta Lazarte, Jin Ma, Tereza Martinu, Liran Levy, William Klement, Matthew White, Jacob Pelling, Zehong Guan, Sassan Azad, Jussi Tikkanen, Vivek Rao, George Tomlinson, Diego Delgado, Shaf Keshavjee, Stephen C. Juvet
  
  European Respiratory Journal 54 (2) 1802126; DOI: 10.1183/13993003.02126-2018 Published 15 August 2019
Sleep
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  The role of CPAP treatment in elderly patients with moderate obstructive sleep apnoea: a multicentre randomised controlled trial
  Silvia Ponce, Esther Pastor, Belen Orosa, Grace Oscullo, Pablo Catalán, Alfonso Martinez, Luis Hernández, Alfonso Muriel, Eusebi Chiner, Miguel Ángel Martínez-García on behalf the Sleep Respiratory Disorders Group of the Sociedad Valenciana de Neumología
  
  European Respiratory Journal 54 (2) 1900518; DOI: 10.1183/13993003.00518-2019 Published 22 August 2019
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  Predictors of delirium after cardiac surgery in patients with sleep disordered breathing
  Maria Tafelmeier, Marvin Knapp, Simon Lebek, Bernhard Floerchinger, Daniele Camboni, Marcus Creutzenberg, Sigrid Wittmann, Florian Zeman, Christof Schmid, Lars Siegfried Maier, Stefan Wagner, Michael Arzt
  
  European Respiratory Journal 54 (2) 1900354; DOI: 10.1183/13993003.00354-2019 Published 8 August 2019
Pleural disease
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  Ultrasound elastography: a novel tool for the differential diagnosis of pleural effusion
  Bin Jiang, Xue-lian Li, Yan Yin, Qin Zhang, Tong Zang, Wang-shu Song, Xue-mei Wang, Jian Kang, Felix J.F. Herth, Gang Hou
  
  European Respiratory Journal 54 (2) 1802018; DOI: 10.1183/13993003.02018-2018 Published 22 August 2019
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  Cost-effectiveness of intrapleural use of tissue plasminogen activator and DNase in pleural infection: evidence from the MIST2 randomised controlled trial
  Ramon Luengo-Fernandez, Erika Penz, Melissa Dobson, Ioannis Psallidas, Andrew J. Nunn, Nick A. Maskell, Najib M. Rahman
  
  European Respiratory Journal 54 (2) 1801550; DOI: 10.1183/13993003.01550-2018 Published 1 August 2019
Pulmonary hypertension
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  Effect of domiciliary oxygen therapy on exercise capacity and quality of life in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension: a randomised, placebo-controlled trial
  Silvia Ulrich, Stéphanie Saxer, Elisabeth D. Hasler, Esther I. Schwarz, Simon R. Schneider, Michael Furian, Patrick R. Bader, Mona Lichtblau, Konrad E. Bloch
  
  European Respiratory Journal 54 (2) 1900276; DOI: 10.1183/13993003.002762019 Published 1 August 2019
Pulmonary hypertension and paediatrics
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  Phenotype characterisation of TBX4 mutation and deletion carriers with neonatal and paediatric pulmonary hypertension
  Csaba Galambos, Mary P. Mullen, Joseph T. Shieh, Nicolaus Schwerk, Matthew J. Kielt, Nicola Ullmann, Renata Boldrini, Irena Stucin-Gantar, Cristina Haass, Manish Bansal, Pankaj B. Agrawal, Joyce Johnson, Donatella Peca, Cecilia Surace, Renato Cutrera, Michael W. Pauciulo, William C. Nichols, Matthias Griese, Dunbar Ivy, Steven H. Abman, Eric D. Austin, Olivier Danhaive
  
  European Respiratory Journal 54 (2) 1801965; DOI: 10.1183/13993003.01965-2018 Published 22 August 2019
Pulmonary hypertension and interstitial lung disease
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  Impact of the revised haemodynamic definition on the diagnosis of pulmonary hypertension in patients with systemic sclerosis
  Sara Jaafar, Scott Visovatti, Amber Young, Suiyuan Huang, Paul Cronin, Dharshan Vummidi, Vallerie McLaughlin, Dinesh Khanna
  
  European Respiratory Journal 54 (2) 1900586; DOI: 10.1183/13993003.00586-2019 Published 22 August 2019
Interstitial lung disease and imaging
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  Radiomic measures from chest high-resolution computed tomography associated with lung function in sarcoidosis
  Sarah M. Ryan, Tasha E. Fingerlin, Margaret Mroz, Briana Barkes, Nabeel Hamzeh, Lisa A. Maier, Nichole E. Carlson
  
  European Respiratory Journal 54 (2) 1900371; DOI: 10.1183/13993003.00371-2019 Published 29 August 2019
Interstitial lung disease
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  Oxygen in patients with fibrotic interstitial lung disease: an international Delphi survey
  Rachel K. Lim, Christopher Humphreys, Julie Morisset, Anne E. Holland, Kerri A. Johannson and the O2 Delphi Collaborators
  
  European Respiratory Journal 54 (2) 1900421; DOI: 10.1183/13993003.00421-2019 Published 8 August 2019
Respiratory infection
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  Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network
  Fei Zhou, Yimin Wang, Yingmei Liu, Xuedong Liu, Li Gu, Xiaoju Zhang, Zenghui Pu, Guoru Yang, Bo Liu, Qingrong Nie, Bing Xue, Jing Feng, Qiang Guo, Jianhua Liu, Hong Fan, Jin Chen, Yongxiang Zhang, Zhenyang Xu, Min Pang, Yu Chen, Xiuhong Nie, Zhigang Cai, Jinfu Xu, Kun Peng, Xiangxin Li, Pingchao Xiang, Zuoqing Zhang, Shujuan Jiang, Xin Su, Jie Zhang, Yanming Li, Xiuhong Jin, Rongmeng Jiang, Jianping Dong, Yuanlin Song, Hong Zhou, Chen Wang, Bin Cao and the CAP-China Network
  
  European Respiratory Journal 54 (2) 1802406; DOI: 10.1183/13993003.02406-2018 Published 1 August 2019

Review

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The Global Initiative for Asthma (GINA): 25 years later
Louis-Philippe Boulet, Helen K. Reddel, Eric Bateman, Søren Pedersen, J. Mark FitzGerald, Paul M. O'Byrne

European Respiratory Journal 54 (2) 1900598; DOI: 10.1183/13993003.00598-2019 Published 29 August 2019

Series

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Airway inflammation in COPD: progress to precision medicine
Christopher Brightling, Neil Greening

European Respiratory Journal 54 (2) 1900651; DOI: 10.1183/13993003.00651-2019 Published 1 August 2019

Agora

Research letters
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  Glossopharyngeal breathing can allow a lung expansion greater than inspiratory capacity in muscular dystrophy
  Antonella LoMauro, Paolo Banfi, Maria Grazia D'Angelo, Andrea Aliverti
  
  European Respiratory Journal 54 (2) 1801938; DOI: 10.1183/13993003.01938-2018 Published 29 August 2019
  
  Supplementary video
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  Population-based prevalence of bronchiectasis and associated comorbidities in South Korea
  Hayoung Choi, Bumhee Yang, Hyewon Nam, Dae-Sung Kyoung, Yun Su Sim, Hye Yun Park, Jae Seung Lee, Sei Won Lee, Yeon-Mok Oh, Seung Won Ra, Sang-Heon Kim, Jang Won Sohn, Ho Joo Yoon, Hyun Lee
  
  European Respiratory Journal 54 (2) 1900194; DOI: 10.1183/13993003.00194-2019 Published 29 August 2019
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  T-box protein 4 mutation causing pulmonary arterial hypertension and lung disease
  Arnaud Maurac, Émilie Lardenois, Mélanie Eyries, Maria Rosa Ghigna, Isabelle Petit, David Montani, Anne Guillaumot, Brice Caput, François Chabot, Ari Chaouat
  
  European Respiratory Journal 54 (2) 1900388; DOI: 10.1183/13993003.00388-2019 Published 22 August 2019
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  Dose–response curves for co-exposure inhalation challenges with ozone and pollen allergen
  Pia Viuf Ørby, Jakob Hjort Bønløkke, Bo Martin Bibby, Peter Ravn, Ole Hertel, Torben Sigsgaard, Vivi Schlünssen
  
  European Respiratory Journal 54 (2) 1801208; DOI: 10.1183/13993003.01208-2018 Published 22 August 2019
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  The airway microbiota in children newly diagnosed with bronchiectasis largely retains its diversity
  Naveen Pillarisetti, David Broderick, Alana Ainsworth, Anna Mulholland, Brett Wagner Mackenzie, Danielle Middleton, Catherine A. Byrnes, Michael W. Taylor
  
  European Respiratory Journal 54 (2) 1900704; DOI: 10.1183/13993003.00704-2019 Published 22 August 2019
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  The proportion of lung cancer patients attending UK lung cancer clinics who would have been eligible for low-dose CT screening
  Kathryn Gracie, Martyn P.T. Kennedy, Georgina Esterbrook, Graham Smith, Parry Blaxill, Ali T. Ameri, Kirsty I.A. Rodger, Jonathan M. Robson, Elankumaran Paramasivam, Rehan Naseer, Peter Smith, Deborah A.B. Ellames, Bana Hawramy, Matthew E.J. Callister
  
  European Respiratory Journal 54 (2) 1802221; DOI: 10.1183/13993003.02221-2018 Published 8 August 2019
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  Higher alveolar nitric oxide in COPD is related to poorer physical capacity and lower oxygen saturation after physical testing
  Marieann Högman, Alexandra Thornadtsson, Kristina Bröms, Christer Janson, Karin Lisspers, Björn Ställberg, Hans Hedenström, Andrei Malinovschi
  
  European Respiratory Journal 54 (2) 1900263; DOI: 10.1183/13993003.00263-2019 Published 1 August 2019
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  Exome sequencing and pathogenicity-network analysis of five French families implicate mTOR signalling and autophagy in familial sarcoidosis
  Alain Calender, Clarice X. Lim, Thomas Weichhart, Adrien Buisson, Valérie Besnard, Pierre Antoine Rollat-Farnier, Claire Bardel, Pascal Roy, Vincent Cottin, Gilles Devouassoux, Amélie Finat, Stéphane Pinson, Serge Lebecque, Hilario Nunes, Dominique Israel-Biet, Abderazzaq Bentaher, Dominique Valeyre, Yves Pacheco in the frame of GSF (Group Sarcoidosis France)
  
  European Respiratory Journal 54 (2) 1900430; DOI: 10.1183/13993003.00430-2019 Published 1 August 2019
Correspondence
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  High nicotine exposure in rodents is unlikely to inform about its toxicity in humans
  Rosalia Emma, Riccardo Polosa, Massimo Caruso
  
  European Respiratory Journal 54 (2) 1801073; DOI: 10.1183/13993003.01073-2018 Published 29 August 2019
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  Lessons learned from animal models: adverse effects of electronic cigarettes
  Laimute Taraseviciene-Stewart
  
  European Respiratory Journal 54 (2) 1901338; DOI: 10.1183/13993003.01338-2019 Published 29 August 2019
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  Inhaled corticosteroids in asthma and the need for universal health coverage
  Mina Gaga, Nikolai Khaltaev, Cherian Varghese
  
  European Respiratory Journal 54 (2) 1900963; DOI: 10.1183/13993003.00963-2019 Published 15 August 2019
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  Using Google Trends to investigate global COPD awareness
  Chan-Na Zhao, Qian Wu, Hai-Feng Pan
  
  European Respiratory Journal 54 (2) 1901076; DOI: 10.1183/13993003.01076-2019 Published 8 August 2019
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  Using Google Trends to investigate global COPD awareness
  Anna Boehm, Alex Pizzini, Thomas Sonnweber, Judith Loeffler-Ragg, Claudia Lamina, Guenter Weiss, Ivan Tancevski
  
  European Respiratory Journal 54 (2) 1901339; DOI: 10.1183/13993003.01339-2019 Published 8 August 2019
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  Predicting respiratory failure in amyotrophic lateral sclerosis: still a long way to go
  Dan Adler, Antoine Poncet, Ruxandra Iancu Ferfoglia, André Truffert, Jean-Paul Janssens
  
  European Respiratory Journal 54 (2) 1901065; DOI: 10.1183/13993003.01065-2019 Published 1 August 2019
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  Predicting respiratory failure in amyotrophic lateral sclerosis: still a long way to go
  Jason Ackrivo, Lauren Elman, Steven M. Kawut
  
  European Respiratory Journal 54 (2) 1901221; DOI: 10.1183/13993003.01221-2019 Published 1 August 2019

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Table of Contents

Editorials

Original Articles

Basic science and interstitial lung disease

Basic science and tuberculosis

Basic science and COPD

Basic science and infection

Basic science and asthma

Imaging

Lung transplantation

Sleep

Pleural disease

Pulmonary hypertension

Pulmonary hypertension and paediatrics

Pulmonary hypertension and interstitial lung disease

Interstitial lung disease and imaging

Interstitial lung disease

Respiratory infection

Review

Series

Agora

Research letters

Correspondence

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