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Table of Contents

01 August 2019; volume 54, issue 2

Editorials

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    Specific challenge testing for occupational asthma: revised handbook
    Hille Suojalehto, Katri Suuronen, Paul Cullinan
    European Respiratory Journal 54 (2) 1901026; DOI: 10.1183/13993003.01026-2019 Published 15 August 2019
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    Dysregulated balance of lung macrophage populations in idiopathic pulmonary fibrosis revealed by single-cell RNA seq: an unstable “ménage-à-trois”
    Bernard Mari, Bruno Crestani
    European Respiratory Journal 54 (2) 1901229; DOI: 10.1183/13993003.01229-2019 Published 22 August 2019
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    When “B” becomes “A”: the emerging threat of influenza B virus
    Lokesh Sharma, Andre Rebaza, Charles S. Dela Cruz
    European Respiratory Journal 54 (2) 1901325; DOI: 10.1183/13993003.01325-2019 Published 15 August 2019
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    Paediatric severe asthma: a need for novel innate molecular phenotypes
    Kristina Laubhahn, Bianca Schaub
    European Respiratory Journal 54 (2) 1901459; DOI: 10.1183/13993003.01459-2019 Published 29 August 2019
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    Re-visiting the HLA dogma
    Antoine Roux, Stijn E. Verleden
    European Respiratory Journal 54 (2) 1901440; DOI: 10.1183/13993003.01440-2019 Published 29 August 2019
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    Ultrasound-based elastography: “hard” to implement in the pleural effusion work-up?
    José M. Porcel
    European Respiratory Journal 54 (2) 1901587; DOI: 10.1183/13993003.01587-2019 Published 22 August 2019
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    Dual intracavitary therapy for pleural infections: leaving reluctance behind
    José M. Porcel
    European Respiratory Journal 54 (2) 1901001; DOI: 10.1183/13993003.01001-2019 Published 1 August 2019
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    The ever-expanding phenotypical spectrum of human TBX4 mutations: from toe to lung
    Meindina G. Haarman, Wilhelmina S. Kerstjens-Frederikse, Rolf M.F. Berger
    European Respiratory Journal 54 (2) 1901504; DOI: 10.1183/13993003.01504-2019 Published 22 August 2019
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    Debating the new haemodynamic definition of pulmonary hypertension: much ado about nothing?
    Gabor Kovacs, Horst Olschewski
    European Respiratory Journal 54 (2) 1901278; DOI: 10.1183/13993003.01278-2019 Published 22 August 2019
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    Are estimations of radiomic image markers dispensable due to recent deep learning findings?
    Martin Obert
    European Respiratory Journal 54 (2) 1901185; DOI: 10.1183/13993003.01185-2019 Published 29 August 2019

Original Articles

  • Basic science and interstitial lung disease

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      Plasma mitochondrial DNA is associated with extrapulmonary sarcoidosis
      Changwan Ryu, Caitlin Brandsdorfer, Taylor Adams, Buqu Hu, Dylan W. Kelleher, Madeleine Yaggi, Edward P. Manning, Anjali Walia, Benjamin Reeves, Hongyi Pan, Julia Winkler, Maksym Minasyan, Charles S. Dela Cruz, Naftali Kaminski, Mridu Gulati, Erica L. Herzog
      European Respiratory Journal 54 (2) 1801762; DOI: 10.1183/13993003.01762-2018 Published 29 August 2019
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      Proliferating SPP1/MERTK-expressing macrophages in idiopathic pulmonary fibrosis
      Christina Morse, Tracy Tabib, John Sembrat, Kristina L. Buschur, Humberto Trejo Bittar, Eleanor Valenzi, Yale Jiang, Daniel J. Kass, Kevin Gibson, Wei Chen, Ana Mora, Panayiotis V. Benos, Mauricio Rojas, Robert Lafyatis
      European Respiratory Journal 54 (2) 1802441; DOI: 10.1183/13993003.02441-2018 Published 22 August 2019
  • Basic science and tuberculosis

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      IL-4 subverts mycobacterial containment in Mycobacterium tuberculosis-infected human macrophages
      Anil Pooran, Malika Davids, Andrew Nel, Aubrey Shoko, Jonathan Blackburn, Keertan Dheda
      European Respiratory Journal 54 (2) 1802242; DOI: 10.1183/13993003.02242-2018 Published 8 August 2019
  • Basic science and COPD

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      Nanoparticle diffusion in spontaneously expectorated sputum as a biophysical tool to probe disease severity in COPD
      Jane F. Chisholm, Siddharth K. Shenoy, Julie K. Shade, Victor Kim, Nirupama Putcha, Kathryn A. Carson, Robert Wise, Nadia N. Hansel, Justin S. Hanes, Jung Soo Suk, Enid Neptune
      European Respiratory Journal 54 (2) 1900088; DOI: 10.1183/13993003.00088-2019 Published 1 August 2019
  • Basic science and infection

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      Tropism of influenza B viruses in human respiratory tract explants and airway organoids
      Christine H.T. Bui, Renee W.Y. Chan, Mandy M.T. Ng, M-C. Cheung, Ka-chun Ng, Megan P.K. Chan, Louisa L.Y. Chan, Joanne H.M. Fong, J.M. Nicholls, J.S. Malik Peiris, Michael C.W. Chan
      European Respiratory Journal 54 (2) 1900008; DOI: 10.1183/13993003.00008-2019 Published 15 August 2019
  • Basic science and asthma

    • Open Access
      Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids
      Prasad Nagakumar, Franz Puttur, Lisa G. Gregory, Laura Denney, Louise Fleming, Andrew Bush, Clare M. Lloyd, Sejal Saglani
      European Respiratory Journal 54 (2) 1801809; DOI: 10.1183/13993003.01809-2018 Published 29 August 2019
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      Neutrophilic inflammation in asthma and defective epithelial translational control
      Abilash Ravi, Saheli Chowdhury, Annemiek Dijkhuis, Peter I. Bonta, Peter J. Sterk, René Lutter
      European Respiratory Journal 54 (2) 1900547; DOI: 10.1183/13993003.00547-2019 Published 15 August 2019
  • Imaging

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      Pulmonary vascular density: comparison of findings on computed tomography imaging with histology
      Farbod N. Rahaghi, Gemma Argemí, Pietro Nardelli, David Domínguez-Fandos, Pedro Arguis, Víctor I. Peinado, James C. Ross, Samuel Y. Ash, Isaac de La Bruere, Carolyn E. Come, Alejandro A. Diaz, Marcelo Sánchez, George R. Washko, Joan Albert Barberà, Raúl San José Estépar
      European Respiratory Journal 54 (2) 1900370; DOI: 10.1183/13993003.00370-2019 Published 15 August 2019
  • Lung transplantation

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      Donor human leukocyte antigen-G single nucleotide polymorphisms are associated with post-lung transplant mortality
      Julieta Lazarte, Jin Ma, Tereza Martinu, Liran Levy, William Klement, Matthew White, Jacob Pelling, Zehong Guan, Sassan Azad, Jussi Tikkanen, Vivek Rao, George Tomlinson, Diego Delgado, Shaf Keshavjee, Stephen C. Juvet
      European Respiratory Journal 54 (2) 1802126; DOI: 10.1183/13993003.02126-2018 Published 15 August 2019
  • Sleep

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      The role of CPAP treatment in elderly patients with moderate obstructive sleep apnoea: a multicentre randomised controlled trial
      Silvia Ponce, Esther Pastor, Belen Orosa, Grace Oscullo, Pablo Catalán, Alfonso Martinez, Luis Hernández, Alfonso Muriel, Eusebi Chiner, Miguel Ángel Martínez-García on behalf the Sleep Respiratory Disorders Group of the Sociedad Valenciana de Neumología
      European Respiratory Journal 54 (2) 1900518; DOI: 10.1183/13993003.00518-2019 Published 22 August 2019
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      Predictors of delirium after cardiac surgery in patients with sleep disordered breathing
      Maria Tafelmeier, Marvin Knapp, Simon Lebek, Bernhard Floerchinger, Daniele Camboni, Marcus Creutzenberg, Sigrid Wittmann, Florian Zeman, Christof Schmid, Lars Siegfried Maier, Stefan Wagner, Michael Arzt
      European Respiratory Journal 54 (2) 1900354; DOI: 10.1183/13993003.00354-2019 Published 8 August 2019
  • Pleural disease

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      Ultrasound elastography: a novel tool for the differential diagnosis of pleural effusion
      Bin Jiang, Xue-lian Li, Yan Yin, Qin Zhang, Tong Zang, Wang-shu Song, Xue-mei Wang, Jian Kang, Felix J.F. Herth, Gang Hou
      European Respiratory Journal 54 (2) 1802018; DOI: 10.1183/13993003.02018-2018 Published 22 August 2019
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      Cost-effectiveness of intrapleural use of tissue plasminogen activator and DNase in pleural infection: evidence from the MIST2 randomised controlled trial
      Ramon Luengo-Fernandez, Erika Penz, Melissa Dobson, Ioannis Psallidas, Andrew J. Nunn, Nick A. Maskell, Najib M. Rahman
      European Respiratory Journal 54 (2) 1801550; DOI: 10.1183/13993003.01550-2018 Published 1 August 2019
  • Pulmonary hypertension

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      Effect of domiciliary oxygen therapy on exercise capacity and quality of life in patients with pulmonary arterial or chronic thromboembolic pulmonary hypertension: a randomised, placebo-controlled trial
      Silvia Ulrich, Stéphanie Saxer, Elisabeth D. Hasler, Esther I. Schwarz, Simon R. Schneider, Michael Furian, Patrick R. Bader, Mona Lichtblau, Konrad E. Bloch
      European Respiratory Journal 54 (2) 1900276; DOI: 10.1183/13993003.002762019 Published 1 August 2019
  • Pulmonary hypertension and paediatrics

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      Phenotype characterisation of TBX4 mutation and deletion carriers with neonatal and paediatric pulmonary hypertension
      Csaba Galambos, Mary P. Mullen, Joseph T. Shieh, Nicolaus Schwerk, Matthew J. Kielt, Nicola Ullmann, Renata Boldrini, Irena Stucin-Gantar, Cristina Haass, Manish Bansal, Pankaj B. Agrawal, Joyce Johnson, Donatella Peca, Cecilia Surace, Renato Cutrera, Michael W. Pauciulo, William C. Nichols, Matthias Griese, Dunbar Ivy, Steven H. Abman, Eric D. Austin, Olivier Danhaive
      European Respiratory Journal 54 (2) 1801965; DOI: 10.1183/13993003.01965-2018 Published 22 August 2019
  • Pulmonary hypertension and interstitial lung disease

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      Impact of the revised haemodynamic definition on the diagnosis of pulmonary hypertension in patients with systemic sclerosis
      Sara Jaafar, Scott Visovatti, Amber Young, Suiyuan Huang, Paul Cronin, Dharshan Vummidi, Vallerie McLaughlin, Dinesh Khanna
      European Respiratory Journal 54 (2) 1900586; DOI: 10.1183/13993003.00586-2019 Published 22 August 2019
  • Interstitial lung disease and imaging

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      Radiomic measures from chest high-resolution computed tomography associated with lung function in sarcoidosis
      Sarah M. Ryan, Tasha E. Fingerlin, Margaret Mroz, Briana Barkes, Nabeel Hamzeh, Lisa A. Maier, Nichole E. Carlson
      European Respiratory Journal 54 (2) 1900371; DOI: 10.1183/13993003.00371-2019 Published 29 August 2019
  • Interstitial lung disease

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      Oxygen in patients with fibrotic interstitial lung disease: an international Delphi survey
      Rachel K. Lim, Christopher Humphreys, Julie Morisset, Anne E. Holland, Kerri A. Johannson and the O2 Delphi Collaborators
      European Respiratory Journal 54 (2) 1900421; DOI: 10.1183/13993003.00421-2019 Published 8 August 2019
  • Respiratory infection

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      Disease severity and clinical outcomes of community-acquired pneumonia caused by non-influenza respiratory viruses in adults: a multicentre prospective registry study from the CAP-China Network
      Fei Zhou, Yimin Wang, Yingmei Liu, Xuedong Liu, Li Gu, Xiaoju Zhang, Zenghui Pu, Guoru Yang, Bo Liu, Qingrong Nie, Bing Xue, Jing Feng, Qiang Guo, Jianhua Liu, Hong Fan, Jin Chen, Yongxiang Zhang, Zhenyang Xu, Min Pang, Yu Chen, Xiuhong Nie, Zhigang Cai, Jinfu Xu, Kun Peng, Xiangxin Li, Pingchao Xiang, Zuoqing Zhang, Shujuan Jiang, Xin Su, Jie Zhang, Yanming Li, Xiuhong Jin, Rongmeng Jiang, Jianping Dong, Yuanlin Song, Hong Zhou, Chen Wang, Bin Cao and the CAP-China Network
      European Respiratory Journal 54 (2) 1802406; DOI: 10.1183/13993003.02406-2018 Published 1 August 2019

Review

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    The Global Initiative for Asthma (GINA): 25 years later
    Louis-Philippe Boulet, Helen K. Reddel, Eric Bateman, Søren Pedersen, J. Mark FitzGerald, Paul M. O'Byrne
    European Respiratory Journal 54 (2) 1900598; DOI: 10.1183/13993003.00598-2019 Published 29 August 2019

Series

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    Airway inflammation in COPD: progress to precision medicine
    Christopher Brightling, Neil Greening
    European Respiratory Journal 54 (2) 1900651; DOI: 10.1183/13993003.00651-2019 Published 1 August 2019

Agora

  • Research letters

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      Glossopharyngeal breathing can allow a lung expansion greater than inspiratory capacity in muscular dystrophy
      Antonella LoMauro, Paolo Banfi, Maria Grazia D'Angelo, Andrea Aliverti
      European Respiratory Journal 54 (2) 1801938; DOI: 10.1183/13993003.01938-2018 Published 29 August 2019
      • Supplementary video
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      Population-based prevalence of bronchiectasis and associated comorbidities in South Korea
      Hayoung Choi, Bumhee Yang, Hyewon Nam, Dae-Sung Kyoung, Yun Su Sim, Hye Yun Park, Jae Seung Lee, Sei Won Lee, Yeon-Mok Oh, Seung Won Ra, Sang-Heon Kim, Jang Won Sohn, Ho Joo Yoon, Hyun Lee
      European Respiratory Journal 54 (2) 1900194; DOI: 10.1183/13993003.00194-2019 Published 29 August 2019
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      T-box protein 4 mutation causing pulmonary arterial hypertension and lung disease
      Arnaud Maurac, Émilie Lardenois, Mélanie Eyries, Maria Rosa Ghigna, Isabelle Petit, David Montani, Anne Guillaumot, Brice Caput, François Chabot, Ari Chaouat
      European Respiratory Journal 54 (2) 1900388; DOI: 10.1183/13993003.00388-2019 Published 22 August 2019
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      Dose–response curves for co-exposure inhalation challenges with ozone and pollen allergen
      Pia Viuf Ørby, Jakob Hjort Bønløkke, Bo Martin Bibby, Peter Ravn, Ole Hertel, Torben Sigsgaard, Vivi Schlünssen
      European Respiratory Journal 54 (2) 1801208; DOI: 10.1183/13993003.01208-2018 Published 22 August 2019
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      The airway microbiota in children newly diagnosed with bronchiectasis largely retains its diversity
      Naveen Pillarisetti, David Broderick, Alana Ainsworth, Anna Mulholland, Brett Wagner Mackenzie, Danielle Middleton, Catherine A. Byrnes, Michael W. Taylor
      European Respiratory Journal 54 (2) 1900704; DOI: 10.1183/13993003.00704-2019 Published 22 August 2019
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      The proportion of lung cancer patients attending UK lung cancer clinics who would have been eligible for low-dose CT screening
      Kathryn Gracie, Martyn P.T. Kennedy, Georgina Esterbrook, Graham Smith, Parry Blaxill, Ali T. Ameri, Kirsty I.A. Rodger, Jonathan M. Robson, Elankumaran Paramasivam, Rehan Naseer, Peter Smith, Deborah A.B. Ellames, Bana Hawramy, Matthew E.J. Callister
      European Respiratory Journal 54 (2) 1802221; DOI: 10.1183/13993003.02221-2018 Published 8 August 2019
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      Higher alveolar nitric oxide in COPD is related to poorer physical capacity and lower oxygen saturation after physical testing
      Marieann Högman, Alexandra Thornadtsson, Kristina Bröms, Christer Janson, Karin Lisspers, Björn Ställberg, Hans Hedenström, Andrei Malinovschi
      European Respiratory Journal 54 (2) 1900263; DOI: 10.1183/13993003.00263-2019 Published 1 August 2019
    • You have accessRestricted access
      Exome sequencing and pathogenicity-network analysis of five French families implicate mTOR signalling and autophagy in familial sarcoidosis
      Alain Calender, Clarice X. Lim, Thomas Weichhart, Adrien Buisson, Valérie Besnard, Pierre Antoine Rollat-Farnier, Claire Bardel, Pascal Roy, Vincent Cottin, Gilles Devouassoux, Amélie Finat, Stéphane Pinson, Serge Lebecque, Hilario Nunes, Dominique Israel-Biet, Abderazzaq Bentaher, Dominique Valeyre, Yves Pacheco in the frame of GSF (Group Sarcoidosis France)
      European Respiratory Journal 54 (2) 1900430; DOI: 10.1183/13993003.00430-2019 Published 1 August 2019
  • Correspondence

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      High nicotine exposure in rodents is unlikely to inform about its toxicity in humans
      Rosalia Emma, Riccardo Polosa, Massimo Caruso
      European Respiratory Journal 54 (2) 1801073; DOI: 10.1183/13993003.01073-2018 Published 29 August 2019
    • You have accessRestricted access
      Lessons learned from animal models: adverse effects of electronic cigarettes
      Laimute Taraseviciene-Stewart
      European Respiratory Journal 54 (2) 1901338; DOI: 10.1183/13993003.01338-2019 Published 29 August 2019
    • You have accessRestricted access
      Inhaled corticosteroids in asthma and the need for universal health coverage
      Mina Gaga, Nikolai Khaltaev, Cherian Varghese
      European Respiratory Journal 54 (2) 1900963; DOI: 10.1183/13993003.00963-2019 Published 15 August 2019
    • You have accessRestricted access
      Using Google Trends to investigate global COPD awareness
      Chan-Na Zhao, Qian Wu, Hai-Feng Pan
      European Respiratory Journal 54 (2) 1901076; DOI: 10.1183/13993003.01076-2019 Published 8 August 2019
    • You have accessRestricted access
      Using Google Trends to investigate global COPD awareness
      Anna Boehm, Alex Pizzini, Thomas Sonnweber, Judith Loeffler-Ragg, Claudia Lamina, Guenter Weiss, Ivan Tancevski
      European Respiratory Journal 54 (2) 1901339; DOI: 10.1183/13993003.01339-2019 Published 8 August 2019
    • You have accessRestricted access
      Predicting respiratory failure in amyotrophic lateral sclerosis: still a long way to go
      Dan Adler, Antoine Poncet, Ruxandra Iancu Ferfoglia, André Truffert, Jean-Paul Janssens
      European Respiratory Journal 54 (2) 1901065; DOI: 10.1183/13993003.01065-2019 Published 1 August 2019
    • You have accessRestricted access
      Predicting respiratory failure in amyotrophic lateral sclerosis: still a long way to go
      Jason Ackrivo, Lauren Elman, Steven M. Kawut
      European Respiratory Journal 54 (2) 1901221; DOI: 10.1183/13993003.01221-2019 Published 1 August 2019
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European Respiratory Journal: 54 (2)
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