Figures
- FIGURE 1
Severe asthma clusters based on epithelial transcriptomics. a) Topological data analysis network constructed with transcripts from bronchial brushings using density analysis by Morse theory, with b) the identified clusters 1–3 coloured yellow, pink and orange. Applying c) body mass index (BMI), d) gastro-oesophageal reflux disease (GORD) treatment and e) blood eosinophil counts as metadata, nodes are coloured by intensity from blue (low intensity) to red (high intensity). f) Heat map of the three top upregulated and three top downregulated differentially expressed genes of wingless tail (WNT)/β-catenin, triggering receptor expressed on myeloid cells (TREM)1 and calcium signalling in the obesity–GORD–proton pump inhibitor treatment (OGP) cluster and in airway epithelial cells exposed to proton pump inhibitors (lansoprazole (L) and rabeprazole (R)) and bile acids (glycodeoxycholic acid (G) and taurodeoxycholic acid (T)). Cmap: connectivity mapping.
