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Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux

Jeanne-Marie Perotin, James P.R. Schofield, Susan J. Wilson, Jonathan Ward, Joost Brandsma, Fabio Strazzeri, Aruna Bansal, Xian Yang, Anthony Rowe, Julie Corfield, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Barbro Dahlén, Stephen J. Fowler, Ildikó Horváth, Peter Howarth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, John H. Riley, Ana R. Sousa, Sven-Erik Dahlen, Ian M. Adcock, Kian Fan Chung, Peter J. Sterk, Paul J. Skipp, Jane E. Collins, Donna E. Davies, Ratko Djukanović on behalf of the U-BIOPRED Study Group
European Respiratory Journal 2019 53: 1900453; DOI: 10.1183/13993003.00453-2019
Jeanne-Marie Perotin
1NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
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  • For correspondence: j-m.perotin-collard@soton.ac.uk
James P.R. Schofield
1NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
2Centre for Proteomic Research, Biological Sciences, University of Southampton, Southampton, UK
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Susan J. Wilson
3The Histochemistry Research Unit, Faculty of Medicine, University of Southampton, Southampton, UK
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Jonathan Ward
3The Histochemistry Research Unit, Faculty of Medicine, University of Southampton, Southampton, UK
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Joost Brandsma
1NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
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Fabio Strazzeri
4Mathematical Sciences, University of Southampton, Southampton, UK
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Aruna Bansal
5Acclarogen Ltd, Cambridge, UK
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Xian Yang
6Data Science Institute, Imperial College London, London, UK
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Anthony Rowe
7Janssen Research and Development, High Wycombe, UK
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Julie Corfield
8Areteva Ltd, Nottingham, UK
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Rene Lutter
9Amsterdam UMC, Dept of Experimental Immunology (Amsterdam Infection and Immunity Institute), University of Amsterdam, Amsterdam, The Netherlands
10Amsterdam UMC, Dept of Respiratory Medicine, University of Amsterdam, Amsterdam, The Netherlands
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Dominick E. Shaw
11NIHR Biomedical Respiratory Research Centre, University of Nottingham, Nottingham, UK
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Per S. Bakke
12Institute of Medicine, University of Bergen, Bergen, Norway
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Massimo Caruso
13Dept of Clinical and Experimental Medicine Hospital University, University of Catania, Catania, Italy
14Dept of Biomedical and Biotechnological Sciences (Biometec), University of Catania, Catania, Italy
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Barbro Dahlén
15Dept of Respiratory Diseases and Allergy, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
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Stephen J. Fowler
16Respiratory and Allergy Research Group, University of Manchester, Manchester, UK
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Ildikó Horváth
17Dept of Pulmonology, Semmelweis University, Budapest, Hungary
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Peter Howarth
1NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
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Norbert Krug
18Fraunhofer Institute for Toxicology and Experimental Medicine Hannover, Hannover, Germany
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Paolo Montuschi
19Faculty of Medicine, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario, Agostino Gemelli IRCCS, Rome, Italy
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Marek Sanak
20Laboratory of Molecular Biology and Clinical Genetics, Medical College, Jagiellonian University, Krakow, Poland
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Thomas Sandström
21Dept of Medicine, Dept of Public Health and Clinical Medicine Respiratory Medicine Unit, Umeå University, Umeå, Sweden
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Kai Sun
7Janssen Research and Development, High Wycombe, UK
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Ioannis Pandis
7Janssen Research and Development, High Wycombe, UK
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Charles Auffray
22European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Université de Lyon, Lyons, France
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Bertrand De Meulder
22European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Université de Lyon, Lyons, France
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Diane Lefaudeux
22European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Université de Lyon, Lyons, France
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  • ORCID record for Diane Lefaudeux
John H. Riley
23Respiratory Therapeutic Unit, GSK, Uxbridge, UK
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Ana R. Sousa
23Respiratory Therapeutic Unit, GSK, Uxbridge, UK
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Sven-Erik Dahlen
24The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
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Ian M. Adcock
25Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
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Kian Fan Chung
25Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
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Peter J. Sterk
11NIHR Biomedical Respiratory Research Centre, University of Nottingham, Nottingham, UK
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Paul J. Skipp
2Centre for Proteomic Research, Biological Sciences, University of Southampton, Southampton, UK
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Jane E. Collins
1NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
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Donna E. Davies
1NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
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Ratko Djukanović
1NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
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Article Information

vol. 53 no. 6
DOI 
https://doi.org/10.1183/13993003.00453-2019
PubMed 
31023846

Published By 
European Respiratory Society
Print ISSN 
0903-1936
Online ISSN 
1399-3003
History 
  • Received December 17, 2018
  • Accepted March 20, 2019
  • Published online June 27, 2019.

Article Versions

  • previous version (April 25, 2019 - 07:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright ©ERS 2019

Author Information

  1. Jeanne-Marie Perotin1⇑,
  2. James P.R. Schofield1,2,
  3. Susan J. Wilson3,
  4. Jonathan Ward3,
  5. Joost Brandsma1,
  6. Fabio Strazzeri4,
  7. Aruna Bansal5,
  8. Xian Yang6,
  9. Anthony Rowe7,
  10. Julie Corfield8,
  11. Rene Lutter9,10,
  12. Dominick E. Shaw11,
  13. Per S. Bakke12,
  14. Massimo Caruso13,14,
  15. Barbro Dahlén15,
  16. Stephen J. Fowler16,
  17. Ildikó Horváth17,
  18. Peter Howarth1,
  19. Norbert Krug18,
  20. Paolo Montuschi19,
  21. Marek Sanak20,
  22. Thomas Sandström21,
  23. Kai Sun7,
  24. Ioannis Pandis7,
  25. Charles Auffray22,
  26. Bertrand De Meulder22,
  27. Diane Lefaudeux22,
  28. John H. Riley23,
  29. Ana R. Sousa23,
  30. Sven-Erik Dahlen24,
  31. Ian M. Adcock25,
  32. Kian Fan Chung25,
  33. Peter J. Sterk11,
  34. Paul J. Skipp2,
  35. Jane E. Collins1,
  36. Donna E. Davies1 and
  37. Ratko Djukanović1
  38. on behalf of the U-BIOPRED Study Group26
  1. Jeanne-Marie Perotin, NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, mailpoint 810, Level F, Sir Henry Wellcome Laboratories, South Block, Southampton University Hospital, Southampton, SO16 6YD, UK. E-mail: j-m.perotin-collard{at}soton.ac.uk
    1. 1NIHR Southampton Biomedical Research Centre, Clinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, UK
    2. 2Centre for Proteomic Research, Biological Sciences, University of Southampton, Southampton, UK
    3. 3The Histochemistry Research Unit, Faculty of Medicine, University of Southampton, Southampton, UK
    4. 4Mathematical Sciences, University of Southampton, Southampton, UK
    5. 5Acclarogen Ltd, Cambridge, UK
    6. 6Data Science Institute, Imperial College London, London, UK
    7. 7Janssen Research and Development, High Wycombe, UK
    8. 8Areteva Ltd, Nottingham, UK
    9. 9Amsterdam UMC, Dept of Experimental Immunology (Amsterdam Infection and Immunity Institute), University of Amsterdam, Amsterdam, The Netherlands
    10. 10Amsterdam UMC, Dept of Respiratory Medicine, University of Amsterdam, Amsterdam, The Netherlands
    11. 11NIHR Biomedical Respiratory Research Centre, University of Nottingham, Nottingham, UK
    12. 12Institute of Medicine, University of Bergen, Bergen, Norway
    13. 13Dept of Clinical and Experimental Medicine Hospital University, University of Catania, Catania, Italy
    14. 14Dept of Biomedical and Biotechnological Sciences (Biometec), University of Catania, Catania, Italy
    15. 15Dept of Respiratory Diseases and Allergy, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    16. 16Respiratory and Allergy Research Group, University of Manchester, Manchester, UK
    17. 17Dept of Pulmonology, Semmelweis University, Budapest, Hungary
    18. 18Fraunhofer Institute for Toxicology and Experimental Medicine Hannover, Hannover, Germany
    19. 19Faculty of Medicine, Catholic University of the Sacred Heart, Fondazione Policlinico Universitario, Agostino Gemelli IRCCS, Rome, Italy
    20. 20Laboratory of Molecular Biology and Clinical Genetics, Medical College, Jagiellonian University, Krakow, Poland
    21. 21Dept of Medicine, Dept of Public Health and Clinical Medicine Respiratory Medicine Unit, Umeå University, Umeå, Sweden
    22. 22European Institute for Systems Biology and Medicine, CNRS-ENS-UCBL-INSERM, Université de Lyon, Lyons, France
    23. 23Respiratory Therapeutic Unit, GSK, Uxbridge, UK
    24. 24The Centre for Allergy Research, The Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    25. 25Cell and Molecular Biology Group, Airways Disease Section, National Heart and Lung Institute, Imperial College London, London, UK
    26. 26Collaborators in the U-BIOPRED Study Group are listed in the acknowledgements section
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    Funding

    • European Respiratory Society

      Fellowship LTRF 2017
    • Association Nationale de Formation Continue en Allergologie (ANAFORCAL)

    • Association des Pneumologues de Champagne-Ardenne (APCA)

    • Association des Allergologues de Champagne-Ardenne (ASALCAR)

    • Innovative Medicines Initiative Joint Undertaking

      grant agreement number 115010
    • Association Régionale pour l‘Aide aux Insuffisants Respiratoires de Champagne-Ardenne (ARAIRCHAR)

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    Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
    Jeanne-Marie Perotin, James P.R. Schofield, Susan J. Wilson, Jonathan Ward, Joost Brandsma, Fabio Strazzeri, Aruna Bansal, Xian Yang, Anthony Rowe, Julie Corfield, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Barbro Dahlén, Stephen J. Fowler, Ildikó Horváth, Peter Howarth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, John H. Riley, Ana R. Sousa, Sven-Erik Dahlen, Ian M. Adcock, Kian Fan Chung, Peter J. Sterk, Paul J. Skipp, Jane E. Collins, Donna E. Davies, Ratko Djukanović
    European Respiratory Journal Jun 2019, 53 (6) 1900453; DOI: 10.1183/13993003.00453-2019

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    Epithelial dysregulation in obese severe asthmatics with gastro-oesophageal reflux
    Jeanne-Marie Perotin, James P.R. Schofield, Susan J. Wilson, Jonathan Ward, Joost Brandsma, Fabio Strazzeri, Aruna Bansal, Xian Yang, Anthony Rowe, Julie Corfield, Rene Lutter, Dominick E. Shaw, Per S. Bakke, Massimo Caruso, Barbro Dahlén, Stephen J. Fowler, Ildikó Horváth, Peter Howarth, Norbert Krug, Paolo Montuschi, Marek Sanak, Thomas Sandström, Kai Sun, Ioannis Pandis, Charles Auffray, Bertrand De Meulder, Diane Lefaudeux, John H. Riley, Ana R. Sousa, Sven-Erik Dahlen, Ian M. Adcock, Kian Fan Chung, Peter J. Sterk, Paul J. Skipp, Jane E. Collins, Donna E. Davies, Ratko Djukanović
    European Respiratory Journal Jun 2019, 53 (6) 1900453; DOI: 10.1183/13993003.00453-2019
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